Filtering for nonlinear genetic regulatory networks with stochastic disturbances

In this paper, the filtering problem is investigated for nonlinear genetic regulatory networks with stochastic disturbances and time delays, where the nonlinear function describing the feedback regulation is assumed to satisfy the sector condition, the stochastic perturbation is in the form of a scalar Brownian motion, and the time delays exist in both the translation process and the feedback regulation process. The purpose of the addressed filtering problem is to estimate the true concentrations of the mRNA and protein. Specifically, we are interested in designing a linear filter such that, in the presence of time delays, stochastic disturbances as well as sector nonlinearities, the filtering dynamics of state estimation for the stochastic genetic regulatory network is exponentially mean square stable with a prescribed decay rate lower bound beta. By using the linear matrix inequality (LMI) technique, sufficient conditions are first derived for ensuring the desired filtering performance for the gene regulatory model, and the filter gain is then characterized in terms of the solution to an LMI, which can be easily solved by using standard software packages. A simulation example is exploited in order to illustrate the effectiveness of the proposed design procedures

Analysis, filtering, and control for Takagi-Sugeno fuzzy models in networked systems

Copyright © 2015 Sunjie Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.The fuzzy logic theory has been proven to be effective in dealing with various nonlinear systems and has a great success in industry applications. Among different kinds of models for fuzzy systems, the so-called Takagi-Sugeno (T-S) fuzzy model has been quite popular due to its convenient and simple dynamic structure as well as its capability of approximating any smooth nonlinear function to any specified accuracy within any compact set. In terms of such a model, the performance analysis and the design of controllers and filters play important roles in the research of fuzzy systems. In this paper, we aim to survey some recent advances on the T-S fuzzy control and filtering problems with various network-induced phenomena. The network-induced phenomena under consideration mainly include communication delays, packet dropouts, signal quantization, and randomly occurring uncertainties (ROUs). With such network-induced phenomena, the developments on T-S fuzzy control and filtering issues are reviewed in detail. In addition, some latest results on this topic are highlighted. In the end, conclusions are drawn and some possible future research directions are pointed out.This work was supported in part by the National Natural Science Foundation of China under Grants 61134009, 61329301, 11301118 and 61174136, the Natural Science Foundation of Jiangsu Province of China under Grant BK20130017, the Fundamental Research Funds for the Central Universities of China under Grant CUSF-DH-D-2013061, the Royal Society of the U.K., and the Alexander von Humboldt Foundation of Germany

Robust filtering for stochastic genetic regulatory networks with time-varying delay

This is the post print version of the article. The official published version can be obtained from the link - Copyright 2009 Elsevier LtdThis paper addresses the robust filtering problem for a class of linear genetic regulatory networks (GRNs) with stochastic disturbances, parameter uncertainties and time delays. The parameter uncertainties are assumed to reside in a polytopic region, the stochastic disturbance is state-dependent described by a scalar Brownian motion, and the time-varying delays enter into both the translation process and the feedback regulation process. We aim to estimate the true concentrations of mRNA and protein by designing a linear filter such that, for all admissible time delays, stochastic disturbances as well as polytopic uncertainties, the augmented state estimation dynamics is exponentially mean square stable with an expected decay rate. A delay-dependent linear matrix inequality (LMI) approach is first developed to derive sufficient conditions that guarantee the exponential stability of the augmented dynamics, and then the filter gains are parameterized in terms of the solution to a set of LMIs. Note that LMIs can be easily solved by using standard software packages. A simulation example is exploited in order to illustrate the effectiveness of the proposed design procedures.This work was supported in part by the Biotechnology and Biological Sciences Research Council (BBSRC) of the U.K. under Grants BB/C506264/1 and 100/EGM17735, an International Joint Project sponsored by the Royal Society of the U.K., the Research Grants Council of Hong Kong under Grant HKU 7031/06P, the National Natural Science Foundation of China under Grant 60804028, and the Alexander von Humboldt Foundation of Germany

H-infinity state estimation for discrete-time complex networks with randomly occurring sensor saturations and randomly varying sensor delays

This is the post-print of the Article. The official published version can be accessed from the link below - Copyright @ 2012 IEEEIn this paper, the state estimation problem is investigated for a class of discrete time-delay nonlinear complex networks with randomly occurring phenomena from sensor measurements. The randomly occurring phenomena include randomly occurring sensor saturations (ROSSs) and randomly varying sensor delays (RVSDs) that result typically from networked environments. A novel sensor model is proposed to describe the ROSSs and the RVSDs within a unified framework via two sets of Bernoulli-distributed white sequences with known conditional probabilities. Rather than employing the commonly used Lipschitz-type function, a more general sector-like nonlinear function is used to describe the nonlinearities existing in the network. The purpose of the addressed problem is to design a state estimator to estimate the network states through available output measurements such that, for all probabilistic sensor saturations and sensor delays, the dynamics of the estimation error is guaranteed to be exponentially mean-square stable and the effect from the exogenous disturbances to the estimation accuracy is attenuated at a given level by means of an $H_{infty}$-norm. In terms of a novel Lyapunov–Krasovskii functional and the Kronecker product, sufficient conditions are established under which the addressed state estimation problem is recast as solving a convex optimization problem via the semidefinite programming method. A simulation example is provided to show the usefulness of the proposed state estimation conditions.This work was supported in part by the Engineering and Physical Sciences Research Council (EPSRC) of the U.K. under Grant GR/S27658/01, the Royal Society of the U.K., the National Natural Science Foundation of China under Grants 61028008, 61134009, 61104125 and 60974030, the Natural Science Foundation of Universities in Anhui Province of China under Grant KJ2011B030, and the Alexander von Humboldt Foundation of Germany

Fuzzy-logic-based control, filtering, and fault detection for networked systems: A Survey

This paper is concerned with the overview of the recent progress in fuzzy-logic-based filtering, control, and fault detection problems. First, the network technologies are introduced, the networked control systems are categorized from the aspects of fieldbuses and industrial Ethernets, the necessity of utilizing the fuzzy logic is justified, and the network-induced phenomena are discussed. Then, the fuzzy logic control strategies are reviewed in great detail. Special attention is given to the thorough examination on the latest results for fuzzy PID control, fuzzy adaptive control, and fuzzy tracking control problems. Furthermore, recent advances on the fuzzy-logic-based filtering and fault detection problems are reviewed. Finally, conclusions are given and some possible future research directions are pointed out, for example, topics on two-dimensional networked systems, wireless networked control systems, Quality-of-Service (QoS) of networked systems, and fuzzy access control in open networked systems.This work was supported in part by the National Natural Science Foundation of China under Grants 61329301, 61374039, 61473163, and 61374127, the Hujiang Foundation of China under Grants C14002 andD15009, the Engineering and Physical Sciences Research Council (EPSRC) of the UK, the Royal Society of the UK, and the Alexander von Humboldt Foundation of Germany

Dwelling Quietly in the Rich Club: Brain Network Determinants of Slow Cortical Fluctuations

For more than a century, cerebral cartography has been driven by investigations of structural and morphological properties of the brain across spatial scales and the temporal/functional phenomena that emerge from these underlying features. The next era of brain mapping will be driven by studies that consider both of these components of brain organization simultaneously -- elucidating their interactions and dependencies. Using this guiding principle, we explored the origin of slowly fluctuating patterns of synchronization within the topological core of brain regions known as the rich club, implicated in the regulation of mood and introspection. We find that a constellation of densely interconnected regions that constitute the rich club (including the anterior insula, amygdala, and precuneus) play a central role in promoting a stable, dynamical core of spontaneous activity in the primate cortex. The slow time scales are well matched to the regulation of internal visceral states, corresponding to the somatic correlates of mood and anxiety. In contrast, the topology of the surrounding "feeder" cortical regions show unstable, rapidly fluctuating dynamics likely crucial for fast perceptual processes. We discuss these findings in relation to psychiatric disorders and the future of connectomics.Comment: 35 pages, 6 figure