49 research outputs found
Sparsity-Promoting Bayesian Dynamic Linear Models
Sparsity-promoting priors have become increasingly popular over recent years
due to an increased number of regression and classification applications
involving a large number of predictors. In time series applications where
observations are collected over time, it is often unrealistic to assume that
the underlying sparsity pattern is fixed. We propose here an original class of
flexible Bayesian linear models for dynamic sparsity modelling. The proposed
class of models expands upon the existing Bayesian literature on sparse
regression using generalized multivariate hyperbolic distributions. The
properties of the models are explored through both analytic results and
simulation studies. We demonstrate the model on a financial application where
it is shown that it accurately represents the patterns seen in the analysis of
stock and derivative data, and is able to detect major events by filtering an
artificial portfolio of assets
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NetDiff – Bayesian model selection for differential gene regulatory network inference
Differential networks allow us to better understand the changes in cellular processes that are exhibited in conditions of interest, identifying variations in gene regulation or protein interaction between, for example, cases and controls, or in response to external stimuli. Here we present a novel methodology for the inference of differential gene regulatory networks from gene expression microarray data. Specifically we apply a Bayesian model selection approach to compare models of conserved and varying network structure, and use Gaussian graphical models to represent the network structures. We apply a variational inference approach to the learning of Gaussian graphical models of gene regulatory networks, that enables us to perform Bayesian model selection that is significantly more computationally efficient than Markov Chain Monte Carlo approaches. Our method is demonstrated to be more robust than independent analysis of data from multiple conditions when applied to synthetic network data, generating fewer false positive predictions of differential edges. We demonstrate the utility of our approach on real world gene expression microarray data by applying it to existing data from amyotrophic lateral sclerosis cases with and without mutations in C9orf72, and controls, where we are able to identify differential network interactions for further investigation