New Combinatorial Construction Techniques for Low-Density Parity-Check Codes and Systematic Repeat-Accumulate Codes

This paper presents several new construction techniques for low-density parity-check (LDPC) and systematic repeat-accumulate (RA) codes. Based on specific classes of combinatorial designs, the improved code design focuses on high-rate structured codes with constant column weights 3 and higher. The proposed codes are efficiently encodable and exhibit good structural properties. Experimental results on decoding performance with the sum-product algorithm show that the novel codes offer substantial practical application potential, for instance, in high-speed applications in magnetic recording and optical communications channels.Comment: 10 pages; to appear in "IEEE Transactions on Communications

The Role of Family-Based Designs in Genome-Wide Association Studies

Genome-Wide Association Studies (GWAS) offer an exciting and promising new research avenue for finding genes for complex diseases. Traditional case-control and cohort studies offer many advantages for such designs. Family-based association designs have long been attractive for their robustness properties, but robustness can mean a loss of power. In this paper we discuss some of the special features of family designs and their relevance in the era of GWAS.Comment: Published in at http://dx.doi.org/10.1214/08-STS280 the Statistical Science (http://www.imstat.org/sts/) by the Institute of Mathematical Statistics (http://www.imstat.org