246 research outputs found

    On the Utility of Representation Learning Algorithms for Myoelectric Interfacing

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    Electrical activity produced by muscles during voluntary movement is a reflection of the firing patterns of relevant motor neurons and, by extension, the latent motor intent driving the movement. Once transduced via electromyography (EMG) and converted into digital form, this activity can be processed to provide an estimate of the original motor intent and is as such a feasible basis for non-invasive efferent neural interfacing. EMG-based motor intent decoding has so far received the most attention in the field of upper-limb prosthetics, where alternative means of interfacing are scarce and the utility of better control apparent. Whereas myoelectric prostheses have been available since the 1960s, available EMG control interfaces still lag behind the mechanical capabilities of the artificial limbs they are intended to steer—a gap at least partially due to limitations in current methods for translating EMG into appropriate motion commands. As the relationship between EMG signals and concurrent effector kinematics is highly non-linear and apparently stochastic, finding ways to accurately extract and combine relevant information from across electrode sites is still an active area of inquiry.This dissertation comprises an introduction and eight papers that explore issues afflicting the status quo of myoelectric decoding and possible solutions, all related through their use of learning algorithms and deep Artificial Neural Network (ANN) models. Paper I presents a Convolutional Neural Network (CNN) for multi-label movement decoding of high-density surface EMG (HD-sEMG) signals. Inspired by the successful use of CNNs in Paper I and the work of others, Paper II presents a method for automatic design of CNN architectures for use in myocontrol. Paper III introduces an ANN architecture with an appertaining training framework from which simultaneous and proportional control emerges. Paper Iv introduce a dataset of HD-sEMG signals for use with learning algorithms. Paper v applies a Recurrent Neural Network (RNN) model to decode finger forces from intramuscular EMG. Paper vI introduces a Transformer model for myoelectric interfacing that do not need additional training data to function with previously unseen users. Paper vII compares the performance of a Long Short-Term Memory (LSTM) network to that of classical pattern recognition algorithms. Lastly, paper vIII describes a framework for synthesizing EMG from multi-articulate gestures intended to reduce training burden

    Analog Photonics Computing for Information Processing, Inference and Optimisation

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    This review presents an overview of the current state-of-the-art in photonics computing, which leverages photons, photons coupled with matter, and optics-related technologies for effective and efficient computational purposes. It covers the history and development of photonics computing and modern analogue computing platforms and architectures, focusing on optimization tasks and neural network implementations. The authors examine special-purpose optimizers, mathematical descriptions of photonics optimizers, and their various interconnections. Disparate applications are discussed, including direct encoding, logistics, finance, phase retrieval, machine learning, neural networks, probabilistic graphical models, and image processing, among many others. The main directions of technological advancement and associated challenges in photonics computing are explored, along with an assessment of its efficiency. Finally, the paper discusses prospects and the field of optical quantum computing, providing insights into the potential applications of this technology.Comment: Invited submission by Journal of Advanced Quantum Technologies; accepted version 5/06/202

    Cancer Subtyping Detection using Biomarker Discovery in Multi-Omics Tensor Datasets

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    This thesis begins with a thorough review of research trends from 2015 to 2022, examining the challenges and issues related to biomarker discovery in multi-omics datasets. The review covers areas of application, proposed methodologies, evaluation criteria used to assess performance, as well as limitations and drawbacks that require further investigation and improvement. This comprehensive overview serves to provide a deeper understanding of the current state of research in this field and the opportunities for future research. It will be particularly useful for those who are interested in this area of study and seeking to expand their knowledge. In the second part of this thesis, a novel methodology is proposed for the identification of significant biomarkers in a multi-omics colon cancer dataset. The integration of clinical features with biomarker discovery has the potential to facilitate the early identification of mortality risk and the development of personalized therapies for a range of diseases, including cancer and stroke. Recent advancements in “omics� technologies have opened up new avenues for researchers to identify disease biomarkers through system-level analysis. Machine learning methods, particularly those based on tensor decomposition techniques, have gained popularity due to the challenges associated with integrative analysis of multi-omics data owing to the complexity of biological systems. Despite extensive efforts towards discovering disease-associated biomolecules by analyzing data from various “omics� experiments, such as genomics, transcriptomics, and metabolomics, the poor integration of diverse forms of 'omics' data has made the integrative analysis of multi-omics data a daunting task. Our research includes ANOVA simultaneous component analysis (ASCA) and Tucker3 modeling to analyze a multivariate dataset with an underlying experimental design. By comparing the spaces spanned by different model components we showed how the two methods can be used for confirmatory analysis and provide complementary information. we demonstrated the novel use of ASCA to analyze the residuals of Tucker3 models to find the optimum one. Increasing the model complexity to more factors removed the last remaining ASCA detectable structure in the residuals. Bootstrap analysis of the core matrix values of the Tucker3 models used to check that additional triads of eigenvectors were needed to describe the remaining structure in the residuals. Also, we developed a new simple, novel strategy for aligning Tucker3 bootstrap models with the Tucker3 model of the original data so that eigenvectors of the three modes, the order of the values in the core matrix, and their algebraic signs match the original Tucker3 model without the need for complicated bookkeeping strategies or performing rotational transformations. Additionally, to avoid getting an overparameterized Tucker3 model, we used the bootstrap method to determine 95% confidence intervals of the loadings and core values. Also, important variables for classification were identified by inspection of loading confidence intervals. The experimental results obtained using the colon cancer dataset demonstrate that our proposed methodology is effective in improving the performance of biomarker discovery in a multi-omics cancer dataset. Overall, our study highlights the potential of integrating multi-omics data with machine learning methods to gain deeper insights into the complex biological mechanisms underlying cancer and other diseases. The experimental results using NIH colon cancer dataset demonstrate that the successful application of our proposed methodology in cancer subtype classification provides a foundation for further investigation into its utility in other disease areas

    Neural-Kalman Schemes for Non-Stationary Channel Tracking and Learning

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    This Thesis focuses on channel tracking in Orthogonal Frequency-Division Multiplexing (OFDM), a widely-used method of data transmission in wireless communications, when abrupt changes occur in the channel. In highly mobile applications, new dynamics appear that might make channel tracking non-stationary, e.g. channels might vary with location, and location rapidly varies with time. Simple examples might be the di erent channel dynamics a train receiver faces when it is close to a station vs. crossing a bridge vs. entering a tunnel, or a car receiver in a route that grows more tra c-dense. Some of these dynamics can be modelled as channel taps dying or being reborn, and so tap birth-death detection is of the essence. In order to improve the quality of communications, we delved into mathematical methods to detect such abrupt changes in the channel, such as the mathematical areas of Sequential Analysis/ Abrupt Change Detection and Random Set Theory (RST), as well as the engineering advances in Neural Network schemes. This knowledge helped us nd a solution to the problem of abrupt change detection by informing and inspiring the creation of low-complexity implementations for real-world channel tracking. In particular, two such novel trackers were created: the Simpli- ed Maximum A Posteriori (SMAP) and the Neural-Network-switched Kalman Filtering (NNKF) schemes. The SMAP is a computationally inexpensive, threshold-based abrupt-change detector. It applies the three following heuristics for tap birth-death detection: a) detect death if the tap gain jumps into approximately zero (memoryless detection); b) detect death if the tap gain has slowly converged into approximately zero (memory detection); c) detect birth if the tap gain is far from zero. The precise parameters for these three simple rules can be approximated with simple theoretical derivations and then ne-tuned through extensive simulations. The status detector for each tap using only these three computationally inexpensive threshold comparisons achieves an error reduction matching that of a close-to-perfect path death/birth detection, as shown in simulations. This estimator was shown to greatly reduce channel tracking error in the target Signal-to-Noise Ratio (SNR) range at a very small computational cost, thus outperforming previously known systems. The underlying RST framework for the SMAP was then extended to combined death/birth and SNR detection when SNR is dynamical and may drift. We analyzed how di erent quasi-ideal SNR detectors a ect the SMAP-enhanced Kalman tracker's performance. Simulations showed SMAP is robust to SNR drift in simulations, although it was also shown to bene t from an accurate SNR detection. The core idea behind the second novel tracker, NNKFs, is similar to the SMAP, but now the tap birth/death detection will be performed via an arti cial neuronal network (NN). Simulations show that the proposed NNKF estimator provides extremely good performance, practically identical to a detector with 100% accuracy. These proposed Neural-Kalman schemes can work as novel trackers for multipath channels, since they are robust to wide variations in the probabilities of tap birth and death. Such robustness suggests a single, low-complexity NNKF could be reusable over di erent tap indices and communication environments. Furthermore, a di erent kind of abrupt change was proposed and analyzed: energy shifts from one channel tap to adjacent taps (partial tap lateral hops). This Thesis also discusses how to model, detect and track such changes, providing a geometric justi cation for this and additional non-stationary dynamics in vehicular situations, such as road scenarios where re ections on trucks and vans are involved, or the visual appearance/disappearance of drone swarms. An extensive literature review of empirically-backed abrupt-change dynamics in channel modelling/measuring campaigns is included. For this generalized framework of abrupt channel changes that includes partial tap lateral hopping, a neural detector for lateral hops with large energy transfers is introduced. Simulation results suggest the proposed NN architecture might be a feasible lateral hop detector, suitable for integration in NNKF schemes. Finally, the newly found understanding of abrupt changes and the interactions between Kalman lters and neural networks is leveraged to analyze the neural consequences of abrupt changes and brie y sketch a novel, abrupt-change-derived stochastic model for neural intelligence, extract some neuro nancial consequences of unstereotyped abrupt dynamics, and propose a new portfolio-building mechanism in nance: Highly Leveraged Abrupt Bets Against Failing Experts (HLABAFEOs). Some communication-engineering-relevant topics, such as a Bayesian stochastic stereotyper for hopping Linear Gauss-Markov (LGM) models, are discussed in the process. The forecasting problem in the presence of expert disagreements is illustrated with a hopping LGM model and a novel structure for a Bayesian stereotyper is introduced that might eventually solve such problems through bio-inspired, neuroscienti cally-backed mechanisms, like dreaming and surprise (biological Neural-Kalman). A generalized framework for abrupt changes and expert disagreements was introduced with the novel concept of Neural-Kalman Phenomena. This Thesis suggests mathematical (Neural-Kalman Problem Category Conjecture), neuro-evolutionary and social reasons why Neural-Kalman Phenomena might exist and found signi cant evidence for their existence in the areas of neuroscience and nance. Apart from providing speci c examples, practical guidelines and historical (out)performance for some HLABAFEO investing portfolios, this multidisciplinary research suggests that a Neural- Kalman architecture for ever granular stereotyping providing a practical solution for continual learning in the presence of unstereotyped abrupt dynamics would be extremely useful in communications and other continual learning tasks.Programa de Doctorado en Multimedia y Comunicaciones por la Universidad Carlos III de Madrid y la Universidad Rey Juan CarlosPresidente: Luis Castedo Ribas.- Secretaria: Ana García Armada.- Vocal: José Antonio Portilla Figuera

    An information-theoretic approach to understanding the neural coding of relevant tactile features

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    Objective: Traditional theories in neuroscience state that tactile afferents present in the glabrous skin of the human hand encode tactile information following a submodality segregation strategy, meaning that each modality (eg. motion, vibration, shape, ... ) is encoded by a different afferent class. Modern theories suggest a submodality convergence instead, in which different afferent classes work together to capture information about the environment through tactile sense. Typically, studies involve electrophysiological recordings of tens of afferents. At the same time, the human hand is filled with around 17.000 afferents. In this thesis, we want to tackle the theoretical gap this poses. Specifically, we aim to address whether the peripheral nervous system relies on population coding to represent tactile information and whether such population coding enables us to disambiguate submodality convergence against the classical segregation. Approach: Understanding the encoding and flow of information in the nervous system is one of the main challenges of modern neuroscience. Neural signals are highly variable and may be non-linear. Moreover, there exist several candidate codes compatible with sensory and behavioral events. For example, they can rely on single cells or populations and also on rate or timing precision. Information-theoretic methods can capture non-linearities while being model independent, statistically robust, and mathematically well-grounded, becoming an ideal candidate to design pipelines for analyzing neural data. Despite information-theoretic methods being powerful for our objective, the vast majority of neural signals we can acquire from living systems makes analyses highly problem-specific. This is so because of the rich variety of biological processes that are involved (continuous, discrete, electrical, chemical, optical, ...). Main results: The first step towards solving the aforementioned challenges was to have a solid methodology we could trust and rely on. Consequently, the first deliverable from this thesis is a toolbox that gathers classical and state-of-the-art information-theoretic approaches and blends them with advanced machine learning tools to process and analyze neural data. Moreover, this toolbox also provides specific guidance on calcium imaging and electrophysiology analyses, encompassing both simulated and experimental data. We then designed an information-theoretic pipeline to analyze large-scale simulations of the tactile afferents that overcomes the current limitations of experimental studies in the field of touch and the peripheral nervous system. We dissected the importance of population coding for the different afferent classes, given their spatiotemporal dynamics. We also demonstrated that different afferent classes encode information simultaneously about very simple features, and that combining classes increases information levels, adding support to the submodality convergence theory. Significance: Fundamental knowledge about touch is essential both to design human-like robots exhibiting naturalistic exploration behavior and prostheses that can properly integrate and provide their user with relevant and useful information to interact with their environment. Demonstrating that the peripheral nervous system relies on heterogeneous population coding can change the designing paradigm of artificial systems, both in terms of which sensors to choose and which algorithms to use, especially in neuromorphic implementations

    Machine Learning and Its Application to Reacting Flows

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    This open access book introduces and explains machine learning (ML) algorithms and techniques developed for statistical inferences on a complex process or system and their applications to simulations of chemically reacting turbulent flows. These two fields, ML and turbulent combustion, have large body of work and knowledge on their own, and this book brings them together and explain the complexities and challenges involved in applying ML techniques to simulate and study reacting flows. This is important as to the world’s total primary energy supply (TPES), since more than 90% of this supply is through combustion technologies and the non-negligible effects of combustion on environment. Although alternative technologies based on renewable energies are coming up, their shares for the TPES is are less than 5% currently and one needs a complete paradigm shift to replace combustion sources. Whether this is practical or not is entirely a different question, and an answer to this question depends on the respondent. However, a pragmatic analysis suggests that the combustion share to TPES is likely to be more than 70% even by 2070. Hence, it will be prudent to take advantage of ML techniques to improve combustion sciences and technologies so that efficient and “greener” combustion systems that are friendlier to the environment can be designed. The book covers the current state of the art in these two topics and outlines the challenges involved, merits and drawbacks of using ML for turbulent combustion simulations including avenues which can be explored to overcome the challenges. The required mathematical equations and backgrounds are discussed with ample references for readers to find further detail if they wish. This book is unique since there is not any book with similar coverage of topics, ranging from big data analysis and machine learning algorithm to their applications for combustion science and system design for energy generation

    Fundamentals

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    Volume 1 establishes the foundations of this new field. It goes through all the steps from data collection, their summary and clustering, to different aspects of resource-aware learning, i.e., hardware, memory, energy, and communication awareness. Machine learning methods are inspected with respect to resource requirements and how to enhance scalability on diverse computing architectures ranging from embedded systems to large computing clusters

    LIPIcs, Volume 258, SoCG 2023, Complete Volume

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    LIPIcs, Volume 258, SoCG 2023, Complete Volum

    Machine Learning Methods with Noisy, Incomplete or Small Datasets

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    In many machine learning applications, available datasets are sometimes incomplete, noisy or affected by artifacts. In supervised scenarios, it could happen that label information has low quality, which might include unbalanced training sets, noisy labels and other problems. Moreover, in practice, it is very common that available data samples are not enough to derive useful supervised or unsupervised classifiers. All these issues are commonly referred to as the low-quality data problem. This book collects novel contributions on machine learning methods for low-quality datasets, to contribute to the dissemination of new ideas to solve this challenging problem, and to provide clear examples of application in real scenarios

    Review of Particle Physics

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    The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 2,143 new measurements from 709 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and baryons. We summarize searches for hypothetical particles such as supersymmetric particles, heavy bosons, axions, dark photons, etc. Particle properties and search limits are listed in Summary Tables. We give numerous tables, figures, formulae, and reviews of topics such as Higgs Boson Physics, Supersymmetry, Grand Unified Theories, Neutrino Mixing, Dark Energy, Dark Matter, Cosmology, Particle Detectors, Colliders, Probability and Statistics. Among the 120 reviews are many that are new or heavily revised, including a new review on Machine Learning, and one on Spectroscopy of Light Meson Resonances. The Review is divided into two volumes. Volume 1 includes the Summary Tables and 97 review articles. Volume 2 consists of the Particle Listings and contains also 23 reviews that address specific aspects of the data presented in the Listings. The complete Review (both volumes) is published online on the website of the Particle Data Group (pdg.lbl.gov) and in a journal. Volume 1 is available in print as the PDG Book. A Particle Physics Booklet with the Summary Tables and essential tables, figures, and equations from selected review articles is available in print, as a web version optimized for use on phones, and as an Android app.United States Department of Energy (DOE) DE-AC02-05CH11231government of Japan (Ministry of Education, Culture, Sports, Science and Technology)Istituto Nazionale di Fisica Nucleare (INFN)Physical Society of Japan (JPS)European Laboratory for Particle Physics (CERN)United States Department of Energy (DOE
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