Significant reduction of electronic correlations upon isovalent Ru substitution of BaFe2As2

We present a detailed investigation of Ba(Fe0.65Ru0.35)2As2 by transport measurements and Angle Resolved photoemission spectroscopy. We observe that Fe and Ru orbitals hybridize to form a coherent electronic structure and that Ru does not induce doping. The number of holes and electrons, deduced from the area of the Fermi Surface pockets, are both about twice larger than in BaFe2As2. The contribution of both carriers to the transport is evidenced by a change of sign of the Hall coefficient with decreasing temperature. Fermi velocities increase significantly with respect to BaFe2As2, suggesting a significant reduction of correlation effects. This may be a key to understand the appearance of superconductivity at the expense of magnetism in undoped iron pnictides

Global Conservation Laws and Femtoscopy of Small Systems

It is increasingly important to understand, in detail, two-pion correlations measured in p+p and d+A collisions. In particular, one wishes to understand the femtoscopic correlations, in order to compare to similar measurements in heavy ion collisions. However, in the low-multiplicity final states of these systems, global conservation laws generate significant N-body correlations which project onto the two-pion space in non-trivial ways and complicate the femtoscopic analysis. We discuss a model-independent formalism to calculate and account for these correlations in measurements.Comment: 7 pages; 10 figures; Invited talk at the Second Workshop on Particle Correlations and Femtoscopy (WPCF06), Sept 9-11 2006, Sao Paulo, Brazi

Modification of jet-like correlations in Pb-Au at the SPS

A high statistics study of high-$p_t$ two-particle azimuthal correlations in Pb-Au at $\sqrt{s_{\rm NN}}=17.2$ GeV, performed by the CERES experiment at the CERN-SPS, is presented. A broad away-side correlation with significant dip at $\Delta\phi\approx\pi$ is observed. The shape and magnitude of the correlation is similar to measurements at RHIC. In comparison to PYTHIA calculations, we observe a significant excess of soft particles at the away-side. A study of charge correlations between trigger and associated particles disfavors vacuum fragmentation of the away-side jet and suggests significant energy transfer of the hard-scattered parton to the medium.Comment: Proceedings to Quark Matter 2009 Conference, Knoxville, Tennessee, US

Quantifying the Cosmic Web I: The large-scale halo ellipticity-ellipticity and ellipticity-direction correlations

The formation of dark matter halos tends to occur anisotropically along the filaments of the Cosmic Web, which induces both ellipticity-ellipticity (EE) correlations between the shapes of halos, as well as ellipticity-direction (ED) cross-correlations between halo shapes and the directions to neighboring halos. We analyze the halo catalogue and the semi-analytic galaxy catalogue of the recent Millennium Run Simulation to measure the EE and ED correlations numerically at four different redshifts (z=0, 0.5, 1 and 2). For the EE correlations, we find that (i) the major-axis correlation is strongest while the intermediate-axis correlation is weakest; (ii) the signal is significant at distances out to 10 Mpc/h; (iii) the signal decreases as z decreases; (iv) and its behavior depends strongly on the halo mass scale, with larger masses showing stronger correlations at large distances. For the ED correlations, we find that (i) the correlations are much stronger than the EE correlations, and are significant even out to distances of 50 Mpc/h; (ii) the signal also decreases as z decreases; (iii) and it increases with halo mass at all distances. We also provide empirical fitting functions for the EE and ED correlations. The EE correlations are found to scale linearly with the linear density correlation function, xi(r). While the ED cross-correlation is found to scale as xi^{1/2}(r) at large distances beyond 10 Mpc/h. The best-fit values of the fitting parameters for the EE and the ED correlations are all determined through chi^{2}-statistics. Our results may be useful for quantifying the filamentary distribution of dark matter halos over a wide range of scales.Comment: MNRAS in press, final version, fitting models refined, cosmic variance errors included, full covariance matrix computed for the error analysis, tables for the EE and ED correlations at z=0 added, 10 pages, 10 figure

A complex relationship among chemical concentration, detection threshold and suprathreshold intensity of bitter compounds

Detection thresholds and psychophysical curves were established for caffeine, quinine-HCl (QHCl), and propylthiouracil (PROP) in a sample of 33 subjects (28 female mean age 24 &plusmn; 4). The mean detection threshold (&plusmn;standard error) for caffeine, QHCl, and PROP was 1.2 &plusmn; 0.12, 0.0083 &plusmn; 0.001, and 0.088 &plusmn; 0.07 mM, respectively. Pearson product&ndash;moment analysis revealed no significant correlations between detection thresholds of the compounds. Psychophysical curves were constructed for each bitter compound over 6 concentrations. There were significant correlations between incremental points of the individual psychophysical curves for QHCl and PROP. Regarding caffeine, there was a specific concentration (6 mM) below and above which the incremental steps in bitterness were correlated. Between compounds, analysis of psychophysical curves revealed no correlations with PROP, but there were significant correlations between the bitterness of caffeine and QHCl at higher concentrations on the psychophysical curve (P &lt; 0.05). Correlation analysis of detection threshold and suprathreshold intensity within a compound revealed a significant correlation between PROP threshold and suprathreshold intensity (r = 0.46&ndash;0.4, P &lt; 0.05), a significant negative correlation for QHCl (r = &ndash;0.33 to &ndash;0.4, P &lt; 0.05), and no correlation for caffeine. The results suggest a complex relationship between chemical concentration, detection threshold, and suprathreshold intensity.<br /

Long-term study of the impact of methotrexate on serum cytokines and lymphocyte subsets in patients with active rheumatoid arthritis: correlation with pharmacokinetic measures

Objective To describe changes in immune parameters observed during long-term methotrexate (MTX) therapy in patients with active rheumatoid arthritis (RA) and explore correlations with simultaneously measured MTX pharmacokinetic (PKC) parameters. Design Prospective, open-label, long-term mechanism of action study. Setting University clinic. Methods MTX was initiated at a single weekly oral dose of 7.5 mg and dose adjusted for efficacy and toxicity for the duration of the study. Standard measures of disease activity were performed at baseline and every 6–36 months. Serum cytokine measurements in blood together with lymphocyte surface immunophenotypes and stimulated peripheral blood mononuclear cell (PBMC) cytokine production were assessed at each clinical evaluation. Results Cytokine concentrations exhibited multiple significant correlations with disease activity measures over time. The strongest correlations observed were for interleukin (IL)-6 (r=0.45, p&#60;0.0001 for swollen joints and r=0.32, p=0.002 for tender joints) and IL-8 (r=0.25, p=0.01 for swollen joints). Significant decreases from baseline were observed in serum IL-1B, IL-6 and IL-8 concentrations. The most significant changes were observed for IL-6 (p&#60;0.001). Significant increases from baseline were observed in IL-2 release from PBMCs ex vivo (p&#60;0.01). In parallel, multiple statistically significant correlations were observed between MTX PKC measures and immune parameters. The change in swollen joint count correlated inversely with the change in area under the curve (AUC) for MTX (r=−0.63, p=0.007). Conclusions MTX therapy of patients with RA is accompanied by a variety of changes in serum cytokine expression, which in turn correlate strongly with clinical disease activity and MTX pharmacokinetics (PKCs). These data strongly support the notion that MTX mediates profound and functionally relevant effects on the immunological hierarchy in the RA lesion