Critical Transitions In a Model of a Genetic Regulatory System

We consider a model for substrate-depletion oscillations in genetic systems, based on a stochastic differential equation with a slowly evolving external signal. We show the existence of critical transitions in the system. We apply two methods to numerically test the synthetic time series generated by the system for early indicators of critical transitions: a detrended fluctuation analysis method, and a novel method based on topological data analysis (persistence diagrams).Comment: 19 pages, 8 figure

Algorithms to automatically quantify the geometric similarity of anatomical surfaces

We describe new approaches for distances between pairs of 2-dimensional surfaces (embedded in 3-dimensional space) that use local structures and global information contained in inter-structure geometric relationships. We present algorithms to automatically determine these distances as well as geometric correspondences. This is motivated by the aspiration of students of natural science to understand the continuity of form that unites the diversity of life. At present, scientists using physical traits to study evolutionary relationships among living and extinct animals analyze data extracted from carefully defined anatomical correspondence points (landmarks). Identifying and recording these landmarks is time consuming and can be done accurately only by trained morphologists. This renders these studies inaccessible to non-morphologists, and causes phenomics to lag behind genomics in elucidating evolutionary patterns. Unlike other algorithms presented for morphological correspondences our approach does not require any preliminary marking of special features or landmarks by the user. It also differs from other seminal work in computational geometry in that our algorithms are polynomial in nature and thus faster, making pairwise comparisons feasible for significantly larger numbers of digitized surfaces. We illustrate our approach using three datasets representing teeth and different bones of primates and humans, and show that it leads to highly accurate results.Comment: Changes with respect to v1, v2: an Erratum was added, correcting the references for one of the three datasets. Note that the datasets and code for this paper can be obtained from the Data Conservancy (see Download column on v1, v2

Ricci Curvature of the Internet Topology

Analysis of Internet topologies has shown that the Internet topology has negative curvature, measured by Gromov's "thin triangle condition", which is tightly related to core congestion and route reliability. In this work we analyze the discrete Ricci curvature of the Internet, defined by Ollivier, Lin, etc. Ricci curvature measures whether local distances diverge or converge. It is a more local measure which allows us to understand the distribution of curvatures in the network. We show by various Internet data sets that the distribution of Ricci cuvature is spread out, suggesting the network topology to be non-homogenous. We also show that the Ricci curvature has interesting connections to both local measures such as node degree and clustering coefficient, global measures such as betweenness centrality and network connectivity, as well as auxilary attributes such as geographical distances. These observations add to the richness of geometric structures in complex network theory.Comment: 9 pages, 16 figures. To be appear on INFOCOM 201