Machine learning methods for histopathological image analysis

Abundant accumulation of digital histopathological images has led to the increased demand for their analysis, such as computer-aided diagnosis using machine learning techniques. However, digital pathological images and related tasks have some issues to be considered. In this mini-review, we introduce the application of digital pathological image analysis using machine learning algorithms, address some problems specific to such analysis, and propose possible solutions.Comment: 23 pages, 4 figure

Efficient Version-Space Reduction for Visual Tracking

Discrminative trackers, employ a classification approach to separate the target from its background. To cope with variations of the target shape and appearance, the classifier is updated online with different samples of the target and the background. Sample selection, labeling and updating the classifier is prone to various sources of errors that drift the tracker. We introduce the use of an efficient version space shrinking strategy to reduce the labeling errors and enhance its sampling strategy by measuring the uncertainty of the tracker about the samples. The proposed tracker, utilize an ensemble of classifiers that represents different hypotheses about the target, diversify them using boosting to provide a larger and more consistent coverage of the version-space and tune the classifiers' weights in voting. The proposed system adjusts the model update rate by promoting the co-training of the short-memory ensemble with a long-memory oracle. The proposed tracker outperformed state-of-the-art trackers on different sequences bearing various tracking challenges.Comment: CRV'17 Conferenc

Exemplar-based Linear Discriminant Analysis for Robust Object Tracking

Tracking-by-detection has become an attractive tracking technique, which treats tracking as a category detection problem. However, the task in tracking is to search for a specific object, rather than an object category as in detection. In this paper, we propose a novel tracking framework based on exemplar detector rather than category detector. The proposed tracker is an ensemble of exemplar-based linear discriminant analysis (ELDA) detectors. Each detector is quite specific and discriminative, because it is trained by a single object instance and massive negatives. To improve its adaptivity, we update both object and background models. Experimental results on several challenging video sequences demonstrate the effectiveness and robustness of our tracking algorithm.Comment: ICIP201

Multiple Instance Learning: A Survey of Problem Characteristics and Applications

Multiple instance learning (MIL) is a form of weakly supervised learning where training instances are arranged in sets, called bags, and a label is provided for the entire bag. This formulation is gaining interest because it naturally fits various problems and allows to leverage weakly labeled data. Consequently, it has been used in diverse application fields such as computer vision and document classification. However, learning from bags raises important challenges that are unique to MIL. This paper provides a comprehensive survey of the characteristics which define and differentiate the types of MIL problems. Until now, these problem characteristics have not been formally identified and described. As a result, the variations in performance of MIL algorithms from one data set to another are difficult to explain. In this paper, MIL problem characteristics are grouped into four broad categories: the composition of the bags, the types of data distribution, the ambiguity of instance labels, and the task to be performed. Methods specialized to address each category are reviewed. Then, the extent to which these characteristics manifest themselves in key MIL application areas are described. Finally, experiments are conducted to compare the performance of 16 state-of-the-art MIL methods on selected problem characteristics. This paper provides insight on how the problem characteristics affect MIL algorithms, recommendations for future benchmarking and promising avenues for research

On Classification with Bags, Groups and Sets

Many classification problems can be difficult to formulate directly in terms of the traditional supervised setting, where both training and test samples are individual feature vectors. There are cases in which samples are better described by sets of feature vectors, that labels are only available for sets rather than individual samples, or, if individual labels are available, that these are not independent. To better deal with such problems, several extensions of supervised learning have been proposed, where either training and/or test objects are sets of feature vectors. However, having been proposed rather independently of each other, their mutual similarities and differences have hitherto not been mapped out. In this work, we provide an overview of such learning scenarios, propose a taxonomy to illustrate the relationships between them, and discuss directions for further research in these areas