14,105 research outputs found
Towards Knowledge in the Cloud
Knowledge in the form of semantic data is becoming more and more ubiquitous, and the need for scalable, dynamic systems to support collaborative work with such distributed, heterogeneous knowledge arises. We extend the ādata in the cloudā approach that is emerging today to āknowledge in the cloudā, with support for handling semantic information, organizing and finding it efficiently and providing reasoning and quality support. Both the life sciences and emergency response fields are identified as strong potential beneficiaries of having āknowledge in the cloudā
An Algorithm to Determine Peer-Reviewers
The peer-review process is the most widely accepted certification mechanism
for officially accepting the written results of researchers within the
scientific community. An essential component of peer-review is the
identification of competent referees to review a submitted manuscript. This
article presents an algorithm to automatically determine the most appropriate
reviewers for a manuscript by way of a co-authorship network data structure and
a relative-rank particle-swarm algorithm. This approach is novel in that it is
not limited to a pre-selected set of referees, is computationally efficient,
requires no human-intervention, and, in some instances, can automatically
identify conflict of interest situations. A useful application of this
algorithm would be to open commentary peer-review systems because it provides a
weighting for each referee with respects to their expertise in the domain of a
manuscript. The algorithm is validated using referee bid data from the 2005
Joint Conference on Digital Libraries.Comment: Rodriguez, M.A., Bollen, J., "An Algorithm to Determine
Peer-Reviewers", Conference on Information and Knowledge Management, in
press, ACM, LA-UR-06-2261, October 2008; ISBN:978-1-59593-991-
Identification of disease-causing genes using microarray data mining and gene ontology
Background: One of the best and most accurate methods for identifying disease-causing genes is monitoring gene expression values in different samples using microarray technology. One of the shortcomings of microarray data is that they provide a small quantity of samples with respect to the number of genes. This problem reduces the classification accuracy of the methods, so gene selection is essential to improve the predictive accuracy and to identify potential marker genes for a disease. Among numerous existing methods for gene selection, support vector machine-based recursive feature elimination (SVMRFE) has become one of the leading methods, but its performance can be reduced because of the small sample size, noisy data and the fact that the method does not remove redundant genes.
Methods: We propose a novel framework for gene selection which uses the advantageous features of conventional methods and addresses their weaknesses. In fact, we have combined the Fisher method and SVMRFE to utilize the advantages of a filtering method as well as an embedded method. Furthermore, we have added a redundancy reduction stage to address the weakness of the Fisher method and SVMRFE. In addition to gene expression values, the proposed method uses Gene Ontology which is a reliable source of information on genes. The use of Gene Ontology can compensate, in part, for the limitations of microarrays, such as having a small number of samples and erroneous measurement results.
Results: The proposed method has been applied to colon, Diffuse Large B-Cell Lymphoma (DLBCL) and prostate cancer datasets. The empirical results show that our method has improved classification performance in terms of accuracy, sensitivity and specificity. In addition, the study of the molecular function of selected genes strengthened the hypothesis that these genes are involved in the process of cancer growth.
Conclusions: The proposed method addresses the weakness of conventional methods by adding a redundancy reduction stage and utilizing Gene Ontology information. It predicts marker genes for colon, DLBCL and prostate cancer with a high accuracy. The predictions made in this study can serve as a list of candidates for subsequent wet-lab verification and might help in the search for a cure for cancers
K-Space at TRECVid 2007
In this paper we describe K-Space participation in
TRECVid 2007. K-Space participated in two tasks, high-level feature extraction and interactive search. We present our approaches for each of these activities and provide a brief analysis of our results. Our high-level feature submission utilized multi-modal low-level features which included visual, audio and temporal elements. Specific concept detectors (such as Face detectors) developed by K-Space partners were also used. We experimented with different machine learning approaches including logistic regression and support vector machines (SVM). Finally we also experimented with both early and late fusion for feature combination. This year we also participated in interactive search, submitting 6 runs. We developed two interfaces which both utilized the same retrieval functionality. Our objective was to measure the effect of context, which was supported to different degrees in each interface, on user performance.
The first of the two systems was a āshotā based interface,
where the results from a query were presented as a ranked
list of shots. The second interface was ābroadcastā based,
where results were presented as a ranked list of broadcasts.
Both systems made use of the outputs of our high-level feature submission as well as low-level visual features
Automatic Metadata Generation using Associative Networks
In spite of its tremendous value, metadata is generally sparse and
incomplete, thereby hampering the effectiveness of digital information
services. Many of the existing mechanisms for the automated creation of
metadata rely primarily on content analysis which can be costly and
inefficient. The automatic metadata generation system proposed in this article
leverages resource relationships generated from existing metadata as a medium
for propagation from metadata-rich to metadata-poor resources. Because of its
independence from content analysis, it can be applied to a wide variety of
resource media types and is shown to be computationally inexpensive. The
proposed method operates through two distinct phases. Occurrence and
co-occurrence algorithms first generate an associative network of repository
resources leveraging existing repository metadata. Second, using the
associative network as a substrate, metadata associated with metadata-rich
resources is propagated to metadata-poor resources by means of a discrete-form
spreading activation algorithm. This article discusses the general framework
for building associative networks, an algorithm for disseminating metadata
through such networks, and the results of an experiment and validation of the
proposed method using a standard bibliographic dataset
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