Testing Foundations of Biological Scaling Theory Using Automated Measurements of Vascular Networks

Scientists have long sought to understand how vascular networks supply blood and oxygen to cells throughout the body. Recent work focuses on principles that constrain how vessel size changes through branching generations from the aorta to capillaries and uses scaling exponents to quantify these changes. Prominent scaling theories predict that combinations of these exponents explain how metabolic, growth, and other biological rates vary with body size. Nevertheless, direct measurements of individual vessel segments have been limited because existing techniques for measuring vasculature are invasive, time consuming, and technically difficult. We developed software that extracts the length, radius, and connectivity of in vivo vessels from contrast-enhanced 3D Magnetic Resonance Angiography. Using data from 20 human subjects, we calculated scaling exponents by four methods--two derived from local properties of branching junctions and two from whole-network properties. Although these methods are often used interchangeably in the literature, we do not find general agreement between these methods, particularly for vessel lengths. Measurements for length of vessels also diverge from theoretical values, but those for radius show stronger agreement. Our results demonstrate that vascular network models cannot ignore certain complexities of real vascular systems and indicate the need to discover new principles regarding vessel lengths

The human and mammalian cerebrum scale by computational power and information resistance

The cerebrum of mammals spans a vast range of sizes and yet has a very regular structure. The amount of folding of the cortical surface and the proportion of white matter gradually increase with size, but the underlying mechanisms remain elusive. Here, two laws are derived to fully explain these cerebral scaling relations. The first law holds that the long-range information flow in the cerebrum is determined by the total cortical surface (i.e., the number of neurons) and the increasing information resistance of long-range connections. Despite having just one free parameter, the first law fits the mammalian cerebrum better than any existing function, both across species and within humans. According to the second law, the white matter volume scales, with a few minor corrections, to the cortical surface area. It follows from the first law that large cerebrums have much local processing and little global information flow. Moreover, paradoxically, a further increase in long-range connections would decrease the efficiency of information flow.Comment: 15 pages, 2 figures; 3 supplement

A Functional Wavelet-Kernel Approach for Continuous-time Prediction

We consider the prediction problem of a continuous-time stochastic process on an entire time-interval in terms of its recent past. The approach we adopt is based on functional kernel nonparametric regression estimation techniques where observations are segments of the observed process considered as curves. These curves are assumed to lie within a space of possibly inhomogeneous functions, and the discretized times series dataset consists of a relatively small, compared to the number of segments, number of measurements made at regular times. We thus consider only the case where an asymptotically non-increasing number of measurements is available for each portion of the times series. We estimate conditional expectations using appropriate wavelet decompositions of the segmented sample paths. A notion of similarity, based on wavelet decompositions, is used in order to calibrate the prediction. Asymptotic properties when the number of segments grows to infinity are investigated under mild conditions, and a nonparametric resampling procedure is used to generate, in a flexible way, valid asymptotic pointwise confidence intervals for the predicted trajectories. We illustrate the usefulness of the proposed functional wavelet-kernel methodology in finite sample situations by means of three real-life datasets that were collected from different arenas