Data-driven modelling of biological multi-scale processes

Biological processes involve a variety of spatial and temporal scales. A holistic understanding of many biological processes therefore requires multi-scale models which capture the relevant properties on all these scales. In this manuscript we review mathematical modelling approaches used to describe the individual spatial scales and how they are integrated into holistic models. We discuss the relation between spatial and temporal scales and the implication of that on multi-scale modelling. Based upon this overview over state-of-the-art modelling approaches, we formulate key challenges in mathematical and computational modelling of biological multi-scale and multi-physics processes. In particular, we considered the availability of analysis tools for multi-scale models and model-based multi-scale data integration. We provide a compact review of methods for model-based data integration and model-based hypothesis testing. Furthermore, novel approaches and recent trends are discussed, including computation time reduction using reduced order and surrogate models, which contribute to the solution of inference problems. We conclude the manuscript by providing a few ideas for the development of tailored multi-scale inference methods.Comment: This manuscript will appear in the Journal of Coupled Systems and Multiscale Dynamics (American Scientific Publishers

Machine Learning for Fluid Mechanics

The field of fluid mechanics is rapidly advancing, driven by unprecedented volumes of data from field measurements, experiments and large-scale simulations at multiple spatiotemporal scales. Machine learning offers a wealth of techniques to extract information from data that could be translated into knowledge about the underlying fluid mechanics. Moreover, machine learning algorithms can augment domain knowledge and automate tasks related to flow control and optimization. This article presents an overview of past history, current developments, and emerging opportunities of machine learning for fluid mechanics. It outlines fundamental machine learning methodologies and discusses their uses for understanding, modeling, optimizing, and controlling fluid flows. The strengths and limitations of these methods are addressed from the perspective of scientific inquiry that considers data as an inherent part of modeling, experimentation, and simulation. Machine learning provides a powerful information processing framework that can enrich, and possibly even transform, current lines of fluid mechanics research and industrial applications.Comment: To appear in the Annual Reviews of Fluid Mechanics, 202

Analysis and Application of Advanced Control Strategies to a Heating Element Nonlinear Model

open4siSustainable control has begun to stimulate research and development in a wide range of industrial communities particularly for systems that demand a high degree of reliability and availability (sustainability) and at the same time characterised by expensive and/or safety critical maintenance work. For heating systems such as HVAC plants, clear conflict exists between ensuring a high degree of availability and reducing costly maintenance times. HVAC systems have highly non-linear dynamics and a stochastic and uncontrollable driving force as input in the form of intake air speed, presenting an interesting challenge for modern control methods. Suitable control methods can provide sustainable maximisation of energy conversion efficiency over wider than normally expected air speeds and temperatures, whilst also giving a degree of “tolerance” to certain faults, providing an important impact on maintenance scheduling, e.g. by capturing the effects of some system faults before they become serious.This paper presents the design of different control strategies applied to a heating element nonlinear model. The description of this heating element was obtained exploiting a data driven and physically meaningful nonlinear continuous time model, which represents a test bed used in passive air conditioning for sustainable housing applications. This model has low complexity while achieving high simulation performance. The physical meaningfulness of the model provides an enhanced insight into the performance and functionality of the system. In return, this information can be used during the system simulation and improved model based and data driven control designs for tight temperature regulation. The main purpose of this study is thus to give several examples of viable and practical designs of control schemes with application to this heating element model. Moreover, extensive simulations and Monte Carlo analysis are the tools for assessing experimentally the main features of the proposed control schemes, in the presence of modelling and measurement errors. These developed control methods are also compared in order to evaluate advantages and drawbacks of the considered solutions. Finally, the exploited simulation tools can serve to highlight the potential application of the proposed control strategies to real air conditioning systems.openTurhan, T.; Simani, S.; Zajic, I.; Gokcen Akkurt, G.Turhan, T.; Simani, Silvio; Zajic, I.; Gokcen Akkurt, G