76,667 research outputs found

    Desarrollo de papeles biocativos por injerto de mol茅culas espec铆ficas en celulosa

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    Tesis (DCI)--FCEFN-UNC, 2019En la presente tesis se presenta el desarrollo de papeles bioactivos con potencial aplicaci贸n en el envasado activo de alimentos. Para tal fin, se propuso el injerto de eugenol, un compuesto de origen natural con propiedades antimicrobiana, antioxidante y repelente de insectos, en celulosa, utilizando 谩cido policarbox铆lico como agente ligante. Con el objetivo de evaluar la escalabilidad del proceso propuesto, se estudiaron distintas tecnolog铆as de curado, tales como calentamiento por convecci贸n, infrarrojo, microondas y conducci贸n. En todos los casos, se analizaron la influencia de las variables operativas sobre el avance de la reacci贸n y propiedades finales del papel preparado, utilizando un dise帽o de experimentos Doehlert para elegir las experiencias a realizar, y analizando los resultados mediante metodolog铆a de superficie de respuesta y an谩lisis estad铆stico ANOVA. Se pudo comprobar que la reacci贸n de injerto de eugenol en papel comercial se produjo con 茅xito en todas las tecnolog铆as estudiadas. Asimismo, se encontraron las condiciones 贸ptimas de reacci贸n para cada una de las tecnolog铆as, para lo cual se busc贸 un compromiso entre el avance de la reacci贸n y las propiedades finales del material (mec谩nicas y color). A partir de estas condiciones, se prepararon papeles y se realiz贸 una caracterizaci贸n m谩s espec铆fica para su aplicaci贸n como envase de alimentos comparando los papeles modificados con el papel virgen. Se analizaron las propiedades mec谩nicas por ensayo de tracci贸n, rasgado y punzonado y se midi贸 la absorci贸n de agua y la capacidad de degradaci贸n. Por otro lado, las propiedades bioactivas analizadas fueron la actividad antioxidante, antimicrobiana, repelente e insecticida de gorgojos (T. castaneum y R. dominica). Una vez probado que el papel modificado presenta buenas caracter铆sticas f铆sicas y bioactivas para su posible aplicaci贸n en el envasado de alimentos, se realizaron prototipos de envasado para harina, como alimento representativo de alimentos derivados de cereales, susceptibles al ataque de plagas. En este estudio se analiz贸 la migraci贸n de reactivos, propiedades organol茅pticas y conservaci贸n del alimento, arrojando resultados promisorios para la industria de envases de alimentos. Finalmente, se realiz贸 una comparaci贸n de las tecnolog铆as de curado ensayadas, analizando diferentes aspectos como avance de reacci贸n, propiedades finales, apariencia, tiempo de reacci贸n, consumo de energ铆a, entre otros, como as铆 tambi茅n disponibilidad y uso de estas tecnolog铆as a escala industrial, seleccionando la tecnolog铆a de conducci贸n como la m谩s adecuada para una propuesta de escalado industrial.Fil: Muratore, Florencia. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales; Argentina.Fil: Muratore, Florencia. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Instituto de Investigaci贸n y Desarrollo en Ingenier铆a de Procesos y Qu铆mica Aplicada; Argentina

    Does international patent collaboration have an effect on entrepreneurship?

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    .Entrepreneurship is one of the main pillars of growth in any economy. Achieving a high rate of entrepreneurship in a region has become the priority objective of governments and firms. However, in many cases, new firm creation is conditioned by relations or collaboration in innovation with agents from other countries. Previous literature has analyzed the mechanisms that foster entrepreneurship. This paper attempts to shed light on the influence of international patent collaboration (IPC) on entrepreneurial activity at country level taking into account the timing of this relationship. An empirical study is proposed to verify whether IPC leads to greater entrepreneurship and to analyze the gestation period between international patenting actions and firm creation. Using the Generalized Method of Moments, the two hypotheses proposed were tested in a data panel of 30 countries for the period 2005鈥2017. Results show the influence of IPC in promoting entrepreneurship in the same year, but especially in the following year. The study offers implications for entrepreneurs and public agents. IPC affects the integration and interaction of international agents in a country, favors the production of new knowledge, and increases positive externalities in a territory. All this facilitates the creation of new companies with a high innovative component.S

    How Does Reciprocity Affect Undergraduate Student Orientation towards Stakeholders?

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    5987Nowadays, students are more aware of the impact of companies on their stakeholders and the need for properly handling their expectations to operationalize corporate social responsibility. Nevertheless, little is known about how certain individual traits may relate to their stance on the issue. This exploratory research contributes to stakeholder theory by analysing the e ect of the individual鈥檚 decision-making process, including the consideration of their social preferences, on their orientation toward stakeholder management. Here, we draw upon a theoretical model for resource-allocation decision-making consisting of reciprocal and non-reciprocal components. Our data, from undergraduate students enrolled in di erent degrees, were collected through a questionnaire and two social within-subject experiments (ultimatum and dictator games). Thus, our results show that the presence of a reciprocal component when decisions are made is positively linked to an instrumental orientation toward stakeholders. In addition, a greater non-reciprocal component in the decision-making process corresponds to a more normative orientation.S

    Balancing the urban stomach: public health, food selling and consumption in London, c. 1558-1640

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    Until recently, public health histories have been predominantly shaped by medical and scientific perspectives, to the neglect of their wider social, economic and political contexts. These medically-minded studies have tended to present broad, sweeping narratives of health policy's explicit successes or failures, often focusing on extraordinary periods of epidemic disease viewed from a national context. This approach is problematic, particularly in studies of public health practice prior to 1800. Before the rise of modern scientific medicine, public health policies were more often influenced by shared social, cultural, economic and religious values which favoured maintaining hierarchy, stability and concern for 'the common good'. These values have frequently been overlooked by modern researchers. This has yielded pessimistic assessments of contemporary sanitation, implying that local authorities did not care about or prioritise the health of populations. Overly medicalised perspectives have further restricted historians' investigation and use of source material, their interpretation of multifaceted and sometimes contested cultural practices such as fasting, and their examination of habitual - and not just extraordinary - health actions. These perspectives have encouraged a focus on reactive - rather than preventative - measures. This thesis contributes to a growing body of research that expands our restrictive understandings of pre-modern public health. It focuses on how public health practices were regulated, monitored and expanded in later Tudor and early Stuart London, with a particular focus on consumption and food-selling. Acknowledging the fundamental public health value of maintaining urban foodways, it investigates how contemporaries sought to manage consumption, food production waste, and vending practices in the early modern City's wards and parishes. It delineates the practical and political distinctions between food and medicine, broadly investigates the activities, reputations of and correlations between London's guild and itinerant food vendors and licensed and irregular medical practitioners, traces the directions in which different kinds of public health policy filtered up or down, and explores how policies were enacted at a national and local level. Finally, it compares and contrasts habitual and extraordinary public health regulations, with a particular focus on how perceptions of and actual food shortages, paired with the omnipresent threat of disease, impacted broader aspects of civic life

    South Yorkshire low carbon energy supply chains: hydrogen sector summary

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    The Idiosyncrasy of Involuntary Musical Imagery Repetition (IMIR) Experiences: The Role of Tempo and Lyrics

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    Involuntary musical imagery repetition (IMIR), colloquially known as 鈥渆arworms,鈥 is a form of musical imagery that arises involuntarily and repeatedly in the mind. A growing number of studies, based on retrospective reports, suggest that IMIR experiences are associated with certain musical features, such as fast tempo and the presence of lyrics, and with individual differences in music training and engagement. However, research to date has not directly assessed the effect of such musical features on IMIR and findings about individual differences in music training and engagement are mixed. Using a cross-sectional design (Study 1, n = 263), we examined IMIR content in terms of tempo (fast, slow) and presence of lyrics (instrumental, vocal), and IMIR characteristics (frequency, duration of episode and section) in relation to 1) the musical content (tempo and lyrics) individuals most commonly expose themselves to (music-listening habits), and 2) music training and engagement. We also used an experimental design (Study 2, n = 80) to test the effects of tempo (fast or slow) and the presence of lyrics (instrumental or vocal) on IMIR retrieval and duration. Results from Study 1 showed that the content of music that individuals are typically exposed to with regard to tempo and lyrics predicted and resembled their IMIR content, and that music engagement, but not music training, predicted IMIR frequency. Music training was, however, shown to predict the duration of IMIR episodes. In the experiment (Study 2), tempo did not predict IMIR retrieval, but the presence of lyrics influenced IMIR duration. Taken together, our findings suggest that IMIR is an idiosyncratic experience primed by the music-listening habits and music engagement of the individual

    Medicina personalizada en lactantes con c谩ncer: Estudio farmacogen茅tico de polimorfismos relacionados con toxicidad y respuesta a la quimioterapia

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    Introducci贸n La farmacogen茅tica es una herramienta de la 鈥淢edicina personalizada鈥 que contribuye a optimizar los tratamientos antineopl谩sicos, adapt谩ndolos a las caracter铆sticas gen茅ticas particulares de cada individuo, maximizando su eficacia y minimizando su toxicidad. El lactante con c谩ncer es un paciente de particular vulnerabilidad y sus comorbilidades tiene una especial repercusi贸n vital. El estudio farmacogen茅tico en esta poblaci贸n resulta pionero y novedoso en nuestro medio. La identificaci贸n de marcadores predictivos espec铆ficos permitir谩 individualizar m谩s la terap茅utica en esta poblaci贸n tan fr谩gil y mejorar en consecuencia su calidad de vida y su pron贸stico vital. Material y m茅todos Estudio de cohortes ambispectivo de pacientes oncol贸gicos entre 1 y 18 meses de edad, receptores de quimioterapia en el Hospital La Fe de Valencia, en el periodo comprendido entre enero 2007 y agosto 2019. La parte retrospectiva comprende hasta diciembre 2015, el estudio prospectivo desde enero 2016 hasta agosto 2019. En primer lugar, se realiza un an谩lisis descriptivo de variables epidemiol贸gicas, cl铆nico/biol贸gicas, terap茅uticas y pron贸sticas de 72 pacientes con dichas caracter铆sticas. Se describe la toxicidad derivada de sus 578 ciclos de quimioterapia (37 variables cl铆nicas), el tiempo de seguimiento y su supervivencia (meses). En segundo lugar, se realiza un estudio anal铆tico cuyo objetivo es correlacionar los polimorfismos gen茅ticos relacionados con la quimioterapia de 64 de los pacientes, la toxicidad grave secundaria al tratamiento (鈮 grado 3 seg煤n CTAE 4.0) y su supervivencia. El genotipado se realiza en el Centro Nacional de Genotipado (CEGEN) mediante la tecnolog铆a MassArray (AgenaBioscience), previa configuraci贸n de un panel farmacogen茅tico pedi谩trico en base a las evidencias recogidas en la base de datos PharmGKB, fichas t茅cnicas de los medicamentos y consorcios internacionales expertos. El an谩lisis estad铆stico descriptivo se realiza con los programas Excel 2016 y R: las variables cualitativas con el recuento num茅rico (porcentaje) y las variables cuantitativas como mediana +/- rango intercuart铆lico ante ausencia de normalidad en la distribuci贸n de los datos (p <0,05, prueba de Kolmogorov-Smirnov). En el an谩lisis de supervivencia se utiliza el estimador Kaplan-Meier. El an谩lisis estad铆stico anal铆tico de correlaci贸n entre polimorfismos y toxicidad se realiza mediante regresi贸n log铆stica penalizada por Elastic Net empleando R. El an谩lisis estad铆stico anal铆tico de correlaci贸n entre polimorfismos y reca铆da/muerte se realiza mediante regresi贸n de Cox penalizada por Elastic Net. Resultados Las variables epidemiol贸gicas, cl铆nico/biol贸gicas y terap茅uticas de los pacientes de la muestra son consecuentes con las descritas en la literatura del lactante con c谩ncer. Las neoplasias con mayor impacto negativo en la supervivencia son la leucemia mielobl谩stica aguda y los tumores del sistema nervioso central. La toxicidad m谩s prevalente es hematol贸gica, digestiva e infecciosa. Existe correlaci贸n entre la toxicidad grave secundaria a los quimioter谩picos en forma de anemia, neutropenia y/o trombopenia y 46 polimorfismos gen茅ticos diferentes. As铆 mismo se encuentra asociaci贸n estad铆sticamente significativa entre la supervivencia global y la supervivencia libre de enfermedad y ciertos polimorfismos gen茅ticos (26 y 13 respectivamente). Los polimorfismos obtenidos pertenecen a genes encargados del transporte (6 genes) y metabolismo (17 genes) de los f谩rmacos, de la reparaci贸n del material gen茅tico y la supresi贸n tumoral (5 genes) y de otras funciones biol贸gicas (4 genes). Conclusi贸n Los resultados del presente estudio muestran correlaci贸n estad铆stica entre 46 polimorfismos de genes implicados en la cin茅tica farmacol贸gica y la reparaci贸n del material gen茅tico y la variabilidad en la toxicidad quimioter谩pica y supervivencia de pacientes lactantes con c谩ncer. En definitiva, aportaciones de la farmacogen茅tica que pueden contribuir a la optimizaci贸n del tratamiento antineopl谩sico en esta poblaci贸n particular y a la predicci贸n de sus riesgos, de especial impacto en los supervivientes del c谩ncer infantil

    Strung pieces: on the aesthetics of television fiction series

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    As layered and long works, television fiction series have aesthetic properties that are built over time, bit by bit. This thesis develops a group of concepts that enable the study of these properties, It argues that a series is made of strung pieces, a system of related elements. The text begins by considering this sequential form within the fields of film and television. This opening chapter defines the object and methodology of research, arguing for a non-essentialist distinction between cinema and television and against the adequacy of textual and contextual analyses as approaches to the aesthetics of these shows. It proposes instead that these programmes should be described as televisual works that can be scrutinised through aesthetic analysis. The next chapters propose a sequence of interrelated concepts. The second chapter contends that series are composed of building blocks that can be either units into which series are divided or motifs that unify series and are dispersed across their pans. These blocks are patterned according to four kinds of relations or principles of composition. Repetition and variation are treated in tandem in the third chapter because of their close connection, given that variation emerges from established repetition. Exception and progression are also discussed together in the fourth chapter since they both require a long view of these serial works. The former, in order to be recognised as a deviation from the patterns of repetition and variation. The latter, In order to be understood in Its many dimensions as the series advances. Each of these concepts is further detailed with additional distinctions between types of units, motifs, repetitions, variations, and exceptions, using illustrative examples from numerous shows. In contrast, the section on progression uses a single series as case study, Carniv脿le (2003-05), because this is the overarching principle that encompasses all the others. The conclusion considers the findings of the research and suggests avenues for their application

    Studies of strategic performance management for classical organizations theory & practice

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    Nowadays, the activities of "Performance Management" have spread very broadly in actually every part of business and management. There are numerous practitioners and researchers from very different disciplines, who are involved in exploring the different contents of performance management. In this thesis, some relevant historic developments in performance management are first reviewed. This includes various theories and frameworks of performance management. Then several management science techniques are developed for assessing performance management, including new methods in Data Envelopment Analysis (DEA) and Soft System Methodology (SSM). A theoretical framework for performance management and its practical procedures (five phases) are developed for "classic" organizations using soft system thinking, and the relationship with the existing theories are explored. Eventually these results are applied in three case studies to verify our theoretical development. One of the main contributions of this work is to point out, and to systematically explore the basic idea that the effective forms and structures of performance management for an organization are likely to depend greatly on the organizational configuration, in order to coordinate well with other management activities in the organization, which has seemingly been neglected in the existing literature of performance management research in the sense that there exists little known research that associated particular forms of performance management with the explicit assumptions of organizational configuration. By applying SSM, this thesis logically derives some main functional blocks of performance management in 'classic' organizations and clarifies the relationships between performance management and other management activities. Furthermore, it develops some new tools and procedures, which can hierarchically decompose organizational strategies and produce a practical model of specific implementation steps for "classic" organizations. Our approach integrates popular types of performance management models. Last but not least, this thesis presents findings from three major cases, which are quite different organizations in terms of management styles, ownership, and operating environment, to illustrate the fliexbility of the developed theoretical framework
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