Reentrant transition of bosons in a quasiperiodic potential

We investigate the behavior of a two dimensional array of Bose-Einstein condensate tubes described by means of a Bose-Hubbard Hamiltonian. Using a Wannier function expansion for the wavefunction in each tube, we compute the Bose-Hubbard parameters related to two different longitudinal potentials, periodic and quasiperiodic. We predict that - upon increasing the external potential strength along the direction of the tubes - the condensate can experience a reentrant transition between a Mott insulating phase and the superfluid one.Comment: Accepted for publication in EP

Untargeted Lipidomic Analysis to Broadly Characterize the Effects of Pathogenic and Non-Pathogenic Staphylococci on Mammalian Lipids

Modification of the host lipidome via secreted enzymes is an integral, but often overlooked aspect of bacterial pathogenesis. In the current era of prevalent antibiotic resistance, knowledge regarding critical host pathogen lipid interactions has the potential for use in developing novel antibacterial agents. While most studies to date on this matter have focused on specific lipids, or select lipid classes, this provides an incomplete picture. Modern methods of untargeted lipidomics have the capacity to overcome these gaps in knowledge and provide a comprehensive understanding of the role of lipid metabolism in the pathogenesis of infections. In an attempt to determine the role of lipid modifying enzymes produced by staphylococci, we exposed bovine heart lipids, a standardized model for the mammalian lipidome, to spent medium from staphylococcal cultures, and analyzed lipid molecular changes by MS/MSALLshotgun lipidomics. We elucidate distinct effects of different staphylococcal isolates, including 4 clinical isolates of the pathogenic species Staphylococcus aureus, a clinical isolate of the normally commensal species S. epidermidis, and the non-pathogenic species S. carnosus. Two highly virulent strains of S. aureus had a more profound effect on mammalian lipids and modified more lipid classes than the other staphylococcal strains. Our studies demonstrate the utility of the applied untargeted lipidomics methodology to profile lipid changes induced by different bacterial secretomes. Finally, we demonstrate the promise of this lipidomics approach in assessing the specificity of bacterial enzymes for mammalian lipid classes. Our data suggests that there may be a correlation between the bacterial expression of lipid-modifying enzymes and virulence, and could facilitate the guided discovery of lipid pathways required for bacterial infections caused by S. aureus and thereby provide insights into the generation of novel antibacterial agents

Mixing and blending syntactic and semantic dependencies

Our system for the CoNLL 2008 shared task uses a set of individual parsers, a set of stand-alone semantic role labellers, and a joint system for parsing and semantic role labelling, all blended together. The system achieved a macro averaged labelled F1- score of 79.79 (WSJ 80.92, Brown 70.49) for the overall task. The labelled attachment score for syntactic dependencies was 86.63 (WSJ 87.36, Brown 80.77) and the labelled F1-score for semantic dependencies was 72.94 (WSJ 74.47, Brown 60.18)

Landau damping: instability mechanism of superfluid Bose gases moving in optical lattices

We investigate Landau damping of Bogoliubov excitations in a dilute Bose gas moving in an optical lattice at finite temperatures. Using a 1D tight-binding model, we explicitly obtain the Landau damping rate, the sign of which determines the stability of the condensate. We find that the sign changes at a certain condensate velocity, which is exactly the same as the critical velocity determined by the Landau criterion of superfluidity. This coincidence of the critical velocities reveals the microscopic mechanism of the Landau instability. This instability mechanism is also consistent with the recent experiment suggesting that a thermal cloud plays a crucial role in breakdown of superfluids, since the thermal cloud is also vital in the Landau damping process. We also examine the possibility of simultaneous disappearance of all damping processes.Comment: 9 pages, 5 figure

Bogoliubov dynamics of condensate collisions using the positive-P representation

We formulate the time-dependent Bogoliubov dynamics of colliding Bose-Einstein condensates in terms of a positive-P representation of the Bogoliubov field. We obtain stochastic evolution equations for the field which converge to the full Bogoliubov description as the number of realisations grows. The numerical effort grows linearly with the size of the computational lattice. We benchmark the efficiency and accuracy of our description against Wigner distribution and exact positive-P methods. We consider its regime of applicability, and show that it is the most efficient method in the common situation - when the total particle number in the system is insufficient for a truncated Wigner treatment.Comment: 9 pages. 5 figure

Norlichexanthone Reduces Virulence Gene Expression and Biofilm Formation in Staphylococcus aureus

Staphylococcus aureus is a serious human pathogen and antibiotic resistant, community-associated strains, such as the methicillin resistant S. aureus (MRSA) strain USA300, continue to spread. To avoid resistance, anti-virulence therapy has been proposed where toxicity is targeted rather than viability. Previously we have shown that norlichexanthone, a small non-reduced tricyclic polyketide produced by fungi and lichens, reduces expression of hla encoding α-hemolysin as well as the regulatory RNAIII of the agr quorum sensing system in S. aureus 8325-4. The aim of the present study was to further characterise the mode of action of norlichexanthone and its effect on biofilm formation. We find that norlichexanthone reduces expression of both hla and RNAIII also in strain USA300. Structurally, norlichexanthone resembles ω-hydroxyemodin that recently was shown to bind the agr two component response regulator, AgrA, which controls expression of RNAIII and the phenol soluble modulins responsible for human neutrophil killing. We show that norlichexanthone reduces S. aureus toxicity towards human neutrophils and interferes directly with AgrA binding to its DNA target. In contrast to ω-hydroxyemodin however, norlichexanthone reduces staphylococcal biofilm formation. Transcriptomic analysis revealed that genes regulated by the SaeRS two-component system are repressed by norlichexanthone when compared to untreated cells, an effect that was mitigated in strain Newman carrying a partially constitutive SaeRS system. Our data show that norlichexanthone treatment reduces expression of key virulence factors in CA-MRSA strain USA300 via AgrA binding and represses biofilm formation