The phenolic complex in flaxseed

Flaxseed is the richest plant source of the lignan secoisolariciresinol diglucoside (SDG). In flaxseed, SDG exists in an oligomeric structure with 3-hydroxy-3-methyl glutaric acid (HMGA) forming a phenolic complex together with p-coumaric acid and ferulic acid glucosides and herbacetin diglucoside (HDG). Epidemiological and animal studies indicate protective effects of flaxseed and SDG towards hormone-dependent cancers and cardiovascular diseases, and reducing effect toward cholesterol levels in blood. Knowledge about the structural features and properties of the phenolic complex are required to further understand bioavailability, bioconversion and bioactivity of flaxseed lignans in humans and animals, the biosynthesis in flaxseed, as well as if it may affect technology and quality of food products containing flaxseed or the phenolic complex. A new fast and simple high-performance liquid chromatographic (HPLC) method was developed for analysing secoisolariciresinol diglucoside (SDG), p-coumaric acid glucoside and ferulic acid glucoside, based on direct hydrolysis of defatted flaxseed flour using alkali. Variations in SDG, p-coumaric acid glucoside and ferulic acid glucoside content were reported in flaxseed samples and bread products containing flaxseed. The composition and properties of flaxseed phenolic complex were studied by reversed-phase liquid chromatography and gel filtration fractionation. Results indicate that the phenolic glucosides exist in oligomers with variable molecular sizes. A complicated linkage pattern and/or possibly interactions with other components may contribute to the observed complexity. SDG and the phenolic complex showed similar hydrogen-donating abilities to ferulic acid but higher than α-tocopherol in the DPPH inhibition metod, suggesting that SDG was the only active antioxidant in the phenolic complex. Contradicting results were obtained on the effect of SDG on levels of Vitamin E and cholesterol in two rat studies

Transformations to achieve the Sustainable Development Goals Includes the SDG Index and Dashboards. Sustainable Development Report 2019

The Sustainable Development Report 2019 presents an updated SDG Index and Dashboards with a refined assessment of countries’ distance to SDG targets. The report has been successfully audited for the first time by the European Commission Joint Research Centre. New indicators have been included, primarily to refine the indicator selection on agriculture, diets, gender equality and freedom of speech. We have also added more metrics for international spillovers, including on fatal work accidents. A new website and data visualization tools are available (http://sustainabledevelopment.report). Once again, Nordic countries – Denmark, Sweden and Finland – top the SDG Index. Yet, even these countries face major challenges in implementing one or several SDGs. No country is on track for achieving all 17 goals with major performance gaps even in the top countries on SDG 12 (Responsible Consumption and Production), SDG 13 (Climate Action), SDG 14 (Life Below Water) and SDG 15 (Life on Land). Income and wealth inequalities, as well as gaps in health and education outcomes by population groups also remain important policy challenges in developing and developed countries alike. The Sustainable Development Report 2019 generates seven major findings: 1. High-level political commitment to the SDGs is falling short of historic promises In September 2019, heads-of-states and governments will convene for the first time in person at the UN in New York to review progress on their promises made four years after the adoption of the 2030 Agenda. Yet, our in-depth analyses show that many have not taken the critical steps to implement the SDGs. Out of 43 countries surveyed on SDG implementation efforts, including all G20 countries and countries with a population greater than 100 million, 33 countries have endorsed the SDGs in official statements since January 1st, 2018. Yet in only 18 of them do central budget documents mention the SDGs. This gap between rhetoric and action must be closed. 2. The SDGs can be operationalized through six SDG Transformations SDG implementation can be organized along the following Transformations: 1. Education, Gender, and Inequality; 2. Health, Wellbeing, and Demography; 3. Energy Decarbonization and Sustainable Industry; 4. Sustainable Food, Land, Water, Oceans; 5. Sustainable Cities and Communities; and 6. Digital Revolution for Sustainable Development. The transformations respect strong interdependencies across the SDGs and can be operationalized by well-defined parts of governments in collaboration with civil society, business, and other stakeholders. They must be underpinned and guided by the principles of Leave No One Behind and Circularity and Decoupling of resource use from human wellbeing. 3. Trends on climate (SDG 13) and biodiversity (SDG 14 and SDG 15) are alarming On average, countries obtain their worst scores on SDG 13 (Climate Action), SDG 14 (Life Below Water) and SDG 15 (Life on Land). No country obtains a “green rating” (synonym of SDG achieved) on SDG 14 (Life Below Water). Trends on greenhouse gas emissions and, even more so, on threatened species are moving in the wrong direction. These findings are in line with the recent reports from the IPCC and IPBES on climate change mitigation and biodiversity protection, respectively. 4. Sustainable land-use and healthy diets require integrated agriculture, climate and health policy interventions Land use and food production are not meeting people’s needs. Agriculture destroys forests and biodiversity, squanders water and releases one-quarter of global greenhouse-gas emissions. In total, 78% of world nations for which data are available obtain a “red rating” (synonym of major SDG challenge) on sustainable nitrogen management; the highest number of “red” rating across all indicators included in the report. At the same time, one-third of food is wasted, 800 million people remain undernourished, 2 billion are deficient in micronutrients, and obesity is on the rise. New indicators on nations’ trophic level and yield gap closure highlight the depth of the challenge. Transformations towards sustainable landuse and food systems are required to balance efficient and resilient agriculture and forestry with biodiversity conservation and restoration as well as healthy diets

Tests and applications of self-consistent cranking in the interacting boson model

The self-consistent cranking method is tested by comparing the cranking calculations in the interacting boson model with the exact results obtained from the SU(3) and O(6) dynamical symmetries and from numerical diagonalization. The method is used to study the spin dependence of shape variables in the $sd$ and $sdg$ boson models. When realistic sets of parameters are used, both models lead to similar results: axial shape is retained with increasing cranking frequency while fluctuations in the shape variable $\gamma$ are slightly reduced.Comment: 9 pages, 3 ps figures, Revte

Workshop report : Earth and Environmental Science for Sustainable Development (Nairobi, March 2017)

This report describes the outcomes of a two-day interactive workshop in Nairobi (Kenya), conducted in March 2017. We gathered 32 delegates from 22 organisations in Kenya to determine sustainable development priorities and consider the role of Earth and environmental science in addressing these. Delegates came from diverse disciplines (e.g., geology, agriculture, geography, hydrology, ecology) and sectors (e.g., academia, commercial, civil society, government). Using the UN Sustainable Development Goals (SDGs) as a reference tool, participants identified primary development challenges and their research and data needs to help address these. Key themes included the food-water-energy nexus, clean water, and natural resources (minerals). Participants co-designed a set of draft science-for-development projects relating to these themes. BGS are using this information, together with the results of additional workshop activities, to inform the development of collaborative science-for-development activities in eastern Africa as part of our commitment to Official Development Assistance (ODA) in the region. We will further develop specific project ideas, using information gathered at this workshop, with appropriate regional and international partners. Information from this workshop provides supporting evidence of expressed development need and stakeholder expertise in eastern Africa. This information will guide future project applications to the Global Challenges Research Fund, and other appropriate research and innovation funding sources. Key Results and Conclusions Small group discussions and group voting generated a collective ranking of SDG priorities. Participants also reflected on where they believe Earth and environmental science can make the greatest contribution to development impact. These rankings were: Overall SDG ranking (Eastern Africa) based on summing of small groups votes: 1. Clean Water and Sanitation (SDG 6) 2. No Poverty (SDG 1) 3. Zero Hunger (SDG 2) 4. Good Health and Wellbeing (SDG 3) 5. Quality Education (SDG 4) Role for Earth and environmental science rankings: 1. Clean Water and Sanitation (SDG 6) 2. Climate Action (SDG 13) 3. Life on Land (SDG 15) 4. Affordable and Clean Energy (SDG 7) 5. Zero Hunger (SDG 2) Group discussions suggested that interconnectedness of SDGs and basic (immediate) development needs were likely to influence the prioritisation process. For example, participants noted that ending poverty (SDG 1), ending hunger (SDG 2) and ensuring access to clean water and sanitation (SDG 6) would underpin progress in many of the other SDGs. We used these rankings to establish three thematic working groups, with each tasked to identify specific challenges, research priorities, information needs and potential projects. Groups were: Food-water-energy nexus. This group identified geographic areas of interest, and considered crosscutting issues (data, cultural and political barriers, partnerships, lessons learned, and capacity building). Clean water and sanitation. This group discussed water availability mapping, enhanced water policy/governance/management, improved catchment management, data gaps, and applied research and training activities. Natural resources (minerals). This group identified activities relating to a Mombasa to Kisumu resource corridor, and artisanal and small-scale mining activities. Developing these activities will require effective science-for-development partnerships. Partnership characteristics of greatest importance to Kenyan participants were (i) sharing of project outputs, (ii) sharing of data, (iii) being treated as equals by other members of the partnership, and (iv) access to training and capacity building

Sustainable Survival for adolescents living with HIV: do SDG-aligned provisions reduce potential mortality risk?

INTRODUCTION: The Sustainable Development Goals (SDGs) present a groundbreaking global development agenda to protect the most vulnerable. Adolescents living with HIV in Sub-Saharan Africa continue to experience extreme health vulnerabilities, but we know little about the impacts of SDG-aligned provisions on their health. This study tests associations of provisions aligned with five SDGs with potential mortality risks. METHODS: Clinical and interview data were gathered from N = 1060 adolescents living with HIV in rural and urban South Africa in 2014 to 2015. All ART-initiated adolescents from 53 government health facilities were identified, and traced in their communities to include those defaulting and lost-to-follow-up. Potential mortality risk was assessed as either: viral suppression failure (1000+ copies/ml) using patient file records, or adolescent self-report of diagnosed but untreated tuberculosis or symptomatic pulmonary tuberculosis. SDG-aligned provisions were measured through adolescent interviews. Provisions aligned with SDGs 1&2 (no poverty and zero hunger) were operationalized as access to basic necessities, social protection and food security; An SDG 3-aligned provision (ensure healthy lives) was having a healthy primary caregiver; An SDG 8-aligned provision (employment for all) was employment of a household member; An SDG 16-aligned provision (protection from violence) was protection from physical, sexual or emotional abuse. Research partners included the South African national government, UNICEF and Pediatric and Adolescent Treatment for Africa. RESULTS: 20.8% of adolescents living with HIV had potential mortality risk - i.e. viral suppression failure, symptomatic untreated TB, or both. All SDG-aligned provisions were significantly associated with reduced potential mortality risk: SDG 1&2 (OR 0.599 CI 0.361 to 0.994); SDG 3 (OR 0.577 CI 0.411 to 0.808); SDG 8 (OR 0.602 CI 0.440 to 0.823) and SDG 16 (OR 0.686 CI 0.505 to 0.933). Access to multiple SDG-aligned provisions showed a strongly graded reduction in potential mortality risk: Among adolescents living with HIV, potential mortality risk was 38.5% with access to no SDG-aligned provisions, and 9.3% with access to all four. CONCLUSIONS: SDG-aligned provisions across a range of SDGs were associated with reduced potential mortality risk among adolescents living with HIV. Access to multiple provisions has the potential to substantially improve survival, suggesting the value of connecting and combining SDGs in our response to paediatric and adolescent HIV

On the Nature of the Strong Emission-Line Galaxies in Cluster Cl 0024+1654: Are Some the Progenitors of Low Mass Spheroidals?

We present new size, line ratio, and velocity width measurements for six strong emission-line galaxies in the galaxy cluster, Cl 0024+1654, at redshift z~0.4. The velocity widths from Keck spectra are all narrow (30<sigma<120 km/s), with three profiles showing double peaks. Four galaxies have low masses (M<10^{10} Mo). Whereas three galaxies were previously reported to be possible AGNs, none exhibit AGN-like emission line ratios or velocity widths. Two or three appear as very blue spirals with the remainder more akin to luminous H-II galaxies undergoing a strong burst of star formation. We propose that after the burst subsides, these galaxies will transform into quiescent dwarfs, and are thus progenitors of some cluster spheroidals (We adopt the nomenclature suggested by Kormendy & Bender (1994), i.e., low-density, dwarf ellipsoidal galaxies like NGC 205 are called `spheroidals' instead of `dwarf ellipticals') seen today.Comment: 14 pages + 2 figures + 1 table, LaTeX, Acc. for publ. in ApJL also available at http://www.ucolick.org/~deep/papers/papers.htm

Closed N=2 Strings: Picture-Changing, Hidden Symmetries and SDG Hierarchy

We study the action of picture-changing and spectral flow operators on a ground ring of ghost number zero operators in the chiral BRST cohomology of the closed N=2 string and describe an infinite set of symmetry charges acting on physical states. The transformations of physical string states are compared with symmetries of self-dual gravity which is the effective field theory of the closed N=2 string. We derive all infinitesimal symmetries of the self-dual gravity equations in 2+2 dimensional spacetime and introduce an infinite hierarchy of commuting flows on the moduli space of self-dual metrics. The dependence on moduli parameters can be recovered by solving the equations of the SDG hierarchy associated with an infinite set of abelian symmetries generated recursively from translations. These non-local abelian symmetries are shown to coincide with the hidden abelian string symmetries responsible for the vanishing of most scattering amplitudes. Therefore, N=2 string theory "predicts" not only self-dual gravity but also the SDG hierarchy.Comment: 41 pages, no figure