Career Transitions and Trajectories: A Case Study in Computing

From artificial intelligence to network security to hardware design, it is well-known that computing research drives many important technological and societal advancements. However, less is known about the long-term career paths of the people behind these innovations. What do their careers reveal about the evolution of computing research? Which institutions were and are the most important in this field, and for what reasons? Can insights into computing career trajectories help predict employer retention? In this paper we analyze several decades of post-PhD computing careers using a large new dataset rich with professional information, and propose a versatile career network model, R^3, that captures temporal career dynamics. With R^3 we track important organizations in computing research history, analyze career movement between industry, academia, and government, and build a powerful predictive model for individual career transitions. Our study, the first of its kind, is a starting point for understanding computing research careers, and may inform employer recruitment and retention mechanisms at a time when the demand for specialized computational expertise far exceeds supply.Comment: To appear in KDD 201

Financial firm resolution policy as a time-consistency problem

In this article, we describe a time-consistency problem that can arise in the government's policy toward insolvent financial firms. We present this problem using a simple model in which shareholders of a large financial firm can raise low-cost debt financing and take on an excessive amount of risk. If this risk backfires, there are spillover effects harmful to the economy as a whole. In such a crisis event, the government's best action is to bail the firm out. The prospect of this bailout is the very reason why the firm can raise debt at low cost while taking on excessive risk. Given the structure of this problem, we discuss government policy that can eliminate or mitigate excessive risk-taking. Efficient resolution policy can eliminate excessive risk-taking only if it can completely eliminate the negative spillover effect. Alternatively, excessive risk-taking can be eliminated either directly by accurate government supervision of system-wide risk-taking, or indirectly by imposing binding capital requirements.Financial markets

Secondary somatic mutations restoring RAD51C and RAD51D associated with acquired resistance to the PARP inhibitor rucaparib in high-grade ovarian carcinoma

High-grade epithelial ovarian carcinomas (OC) containing mutated BRCA1 or BRCA2 (BRCA1/2) homologous recombination (HR) genes are sensitive to platinum-based chemotherapy and poly(ADP-ribose) polymerase inhibitors (PARPi), while restoration of HR function due to secondary mutations in BRCA1/2 has been recognized as an important resistance mechanism. We sequenced core HR pathway genes in 12 pairs of pre-treatment and post-progression tumor biopsy samples collected from patients in ARIEL2 Part 1, a phase 2 study of the PARPi rucaparib as treatment for platinum-sensitive, relapsed OC. In six of 12 pre-treatment biopsies, a truncation mutation in BRCA1, RAD51C or RAD51D was identified. In five of six paired post-progression biopsies, one or more secondary mutations restored the open reading frame. Four distinct secondary mutations and spatial heterogeneity were observed for RAD51C. In vitro complementation assays and a patient-derived xenograft (PDX), as well as predictive molecular modeling, confirmed that resistance to rucaparib was associated with secondary mutations