Maintaining Ethical Integrity During Clinical Research in Midwifery

This paper explores the issues related to maintaining ethical integrity during clinical research in midwifery. An overview of what are ethical principles is provided within the discussion. Particular attention is paid to some of the ethical issues that may face researchers and clinicians such as researching with vulnerable groups in midwifery like neonates, and obtaining ethical consent. Guidelines are proposed to aid both researchers and clinicians to know when research is being conducted in an ethical manner

Structuring the process of integrity maintenance (extended version)

Two different approaches have been traditionally considered for dealing with the process of integrity constraints enforcement: integrity checking and integrity maintenance. However, while previous research in the first approach has mainly addressed efficiency issues, research in the second approach has been mainly concentrated in being able to generate all possible repairs that falsify an integrity constraint violation. In this paper we address efficiency issues during the process of integrity maintenance. In this sense, we propose a technique which improves efficiency of existing methods by defining the order in which maintenance of integrity constraints should be performed. Moreover, we use also this technique for being able to handle in an integrated way the integrity constraintsPostprint (published version

Disconnected aging: cerebral white matter integrity and age-related differences in cognition.

Cognition arises as a result of coordinated processing among distributed brain regions and disruptions to communication within these neural networks can result in cognitive dysfunction. Cortical disconnection may thus contribute to the declines in some aspects of cognitive functioning observed in healthy aging. Diffusion tensor imaging (DTI) is ideally suited for the study of cortical disconnection as it provides indices of structural integrity within interconnected neural networks. The current review summarizes results of previous DTI aging research with the aim of identifying consistent patterns of age-related differences in white matter integrity, and of relationships between measures of white matter integrity and behavioral performance as a function of adult age. We outline a number of future directions that will broaden our current understanding of these brain-behavior relationships in aging. Specifically, future research should aim to (1) investigate multiple models of age-brain-behavior relationships; (2) determine the tract-specificity versus global effect of aging on white matter integrity; (3) assess the relative contribution of normal variation in white matter integrity versus white matter lesions to age-related differences in cognition; (4) improve the definition of specific aspects of cognitive functioning related to age-related differences in white matter integrity using information processing tasks; and (5) combine multiple imaging modalities (e.g., resting-state and task-related functional magnetic resonance imaging; fMRI) with DTI to clarify the role of cerebral white matter integrity in cognitive aging

A Review of integrity constraint maintenance and view updating techniques

Two interrelated problems may arise when updating a database. On one hand, when an update is applied to the database, integrity constraints may become violated. In such case, the integrity constraint maintenance approach tries to obtain additional updates to keep integrity constraints satisfied. On the other hand, when updates of derived or view facts are requested, a view updating mechanism must be applied to translate the update request into correct updates of the underlying base facts. This survey reviews the research performed on integrity constraint maintenance and view updating. It is proposed a general framework to classify and to compare methods that tackle integrity constraint maintenance and/or view updating. Then, we analyze some of these methods in more detail to identify their actual contribution and the main limitations they may present.Postprint (published version

Pretreatment cognitive and neural differences between sapropterin dihydrochloride responders and non-responders with phenylketonuria

Sapropterin dihydrochloride (BH4) reduces phenylalanine (Phe) levels and improves white matter integrity in a subset of individuals with phenylketonuria (PKU) known as “responders.” Although prior research has identified biochemical and genotypic differences between BH4 responders and non-responders, cognitive and neural differences remain largely unexplored. To this end, we compared intelligence and white matter integrity prior to treatment with BH4 in 13 subsequent BH4 responders with PKU, 16 subsequent BH4 non-responders with PKU, and 12 healthy controls. Results indicated poorer intelligence and white matter integrity in non-responders compared to responders prior to treatment. In addition, poorer white matter integrity was associated with greater variability in Phe across the lifetime in non-responders but not in responders. These results underscore the importance of considering PKU as a multi-faceted, multi-dimensional disorder and point to the need for additional research to delineate characteristics that predict response to treatment with BH4

A broad character education approach for addressing America’s cheating culture

Cheating is highly prevalent in American high school students and across the globe. Although numerous approaches are in place to combat this issue, most character education approaches have focused primarily on fostering moral integrity (a strength of moral character). Here, we argue that a broad character education approach to addressing cheating culture—one drawing on moral, civic, performance, and intellectual character strengths – may provide new ways to address this epidemic. We begin by outlining current scholarship and approaches to addressing cheating. We then note that many of these interventions aim to foster academic integrity through a moral lens and posit that a broad character education approach that draws on all four areas of character (not moral character alone) may provide additional avenues for promoting student integrity and dissuading academic dishonesty. We discuss the potential benefits of building specific strengths within each character domain in relation to integrity, and offer suggestions for further research. Finally, we conclude with a discussion of how educators might leverage each of these character areas and the interplay between them to foster academic integrit