Real-valued average consensus over noisy quantized channels

This paper concerns the average consensus problem with the constraint of quantized communication between nodes. A broad class of algorithms is analyzed, in which the transmission strategy, which decides what value to communicate to the neighbours, can include various kinds of rounding, probabilistic quantization, and bounded noise. The arbitrariness of the transmission strategy is compensated by a feedback mechanism which can be interpreted as a self-inhibitory action. The result is that the average of the nodes state is not conserved across iterations, and the nodes do not converge to a consensus; however, we show that both errors can be made as small as desired. Bounds on these quantities involve the spectral properties of the graph and can be proved by employing elementary techniques of LTI systems analysis

DUDE-Seq: Fast, Flexible, and Robust Denoising for Targeted Amplicon Sequencing

We consider the correction of errors from nucleotide sequences produced by next-generation targeted amplicon sequencing. The next-generation sequencing (NGS) platforms can provide a great deal of sequencing data thanks to their high throughput, but the associated error rates often tend to be high. Denoising in high-throughput sequencing has thus become a crucial process for boosting the reliability of downstream analyses. Our methodology, named DUDE-Seq, is derived from a general setting of reconstructing finite-valued source data corrupted by a discrete memoryless channel and effectively corrects substitution and homopolymer indel errors, the two major types of sequencing errors in most high-throughput targeted amplicon sequencing platforms. Our experimental studies with real and simulated datasets suggest that the proposed DUDE-Seq not only outperforms existing alternatives in terms of error-correction capability and time efficiency, but also boosts the reliability of downstream analyses. Further, the flexibility of DUDE-Seq enables its robust application to different sequencing platforms and analysis pipelines by simple updates of the noise model. DUDE-Seq is available at http://data.snu.ac.kr/pub/dude-seq

Coordination of passive systems under quantized measurements

In this paper we investigate a passivity approach to collective coordination and synchronization problems in the presence of quantized measurements and show that coordination tasks can be achieved in a practical sense for a large class of passive systems.Comment: 40 pages, 1 figure, submitted to journal, second round of revie