Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement.

Eukaryotic DNA is packaged into nucleosome arrays, which are repositioned by chromatin remodeling complexes to control DNA accessibility. The Saccharomyces cerevisiae RSC (Remodeling the Structure of Chromatin) complex, a member of the SWI/SNF chromatin remodeler family, plays critical roles in genome maintenance, transcription, and DNA repair. Here, we report cryo-electron microscopy (cryo-EM) and crosslinking mass spectrometry (CLMS) studies of yeast RSC complex and show that RSC is composed of a rigid tripartite core and two flexible lobes. The core structure is scaffolded by an asymmetric Rsc8 dimer and built with the evolutionarily conserved subunits Sfh1, Rsc6, Rsc9 and Sth1. The flexible ATPase lobe, composed of helicase subunit Sth1, Arp7, Arp9 and Rtt102, is anchored to this core by the N-terminus of Sth1. Our cryo-EM analysis of RSC bound to a nucleosome core particle shows that in addition to the expected nucleosome-Sth1 interactions, RSC engages histones and nucleosomal DNA through one arm of the core structure, composed of the Rsc8 SWIRM domains, Sfh1 and Npl6. Our findings provide structural insights into the conserved assembly process for all members of the SWI/SNF family of remodelers, and illustrate how RSC selects, engages, and remodels nucleosomes

Low-Floor Tanner Codes via Hamming-Node or RSCC-Node Doping

We study the design of structured Tanner codes with low error-rate floors on the AWGN channel. The design technique involves the “doping” of standard LDPC (proto-)graphs, by which we mean Hamming or recursive systematic convolutional (RSC) code constraints are used together with single-parity-check (SPC) constraints to construct a code’s protograph. We show that the doping of a “good” graph with Hamming or RSC codes is a pragmatic approach that frequently results in a code with a good threshold and very low error-rate floor. We focus on low-rate Tanner codes, in part because the design of low-rate, low-floor LDPC codes is particularly difficult. Lastly, we perform a simple complexity analysis of our Tanner codes and examine the performance of lower-complexity, suboptimal Hamming-node decoders

Comparison of software models for energy savings from cool roofs

A web-based Roof Savings Calculator (RSC) has been deployed for the United States Department of Energy as an industry-consensus tool to help building owners, manufacturers, distributors, contractors and researchers easily run complex roof and attic simulations. RSC simulates multiple roof and attic technologies for side-by-side comparison including reflective roofs, different roof slopes, above sheathing ventilation, radiant barriers, low-emittance roof surfaces, duct location, duct leakage rates, multiple substrate types, and insulation levels. Annual simulations of hour-by-hour, whole-building performance are used to provide estimated annual energy and cost savings from reduced HVAC use. While RSC reported similar cooling savings to other simulation engines, heating penalty varied significantly. RSC results show reduced cool roofing cost-effectiveness, thus mitigating expected economic incentives for this countermeasure to the urban heat island effect. This paper consolidates comparison of RSC's projected energy savings to other simulation engines including DOE-2.1E, AtticSim, Micropas, and EnergyPlus. Also included are comparisons to previous simulation-based studies, analysis of RSC cooling savings and heating penalties, the role of radiative heat exchange in an attic assembly, and changes made for increased accuracy of the duct model. Radiant heat transfer and duct interaction not previously modeled is considered a major contributor to heating penalties

Acoustic resonances in two dimensional radial sonic crystals shells

Radial sonic crystals (RSC) are fluidlike structures infinitely periodic along the radial direction. They have been recently introduced and are only possible thanks to the anisotropy of specially designed acoustic metamaterials [see Phys. Rev. Lett. {\bf 103} 064301 (2009)]. We present here a comprehensive analysis of two-dimensional RSC shells, which consist of a cavity defect centered at the origin of the crystal and a finite thickness crystal shell surrounded by a fluidlike background. We develop analytic expressions demonstrating that, like for other type of crystals (photonic or phononic) with defects, these shells contain Fabry-Perot like resonances and strongly localized modes. The results are completely general and can be extended to three dimensional acoustic structures and to their photonic counterparts, the radial photonic crystals

A comparative analysis of corporate social responsibility between the banking sector and others in Brazil

Este artigo objetiva estudar a Responsabilidade Social Corporativa (RSC) nos bancos brasileiros comparativamente a empresas de outros setores, utilizando dados de ações sociais da empresa brasileira relativos ao período 1996-2008, fazendo uso de análise uni e multivariada. Os resultados de comparação de médias mostraram mais elevados índices de RSC em empresas do setor bancário relativamente aos demais segmentos. Estimando-se modelos de regressão linear, os resultados indicam que o fato de a empresa ser um banco (variável dummy) afeta positivamente a intensidade de RSC, controlando por outras variáveis explicativas apontadas pela literatura com possível poder de influência sobre a RSC (ROA, oportunidades de crescimento, tamanho). Analisando- se separadamente as distintas vertentes de ação social, verifica-se que a RSC interna, a mais forte da empresa brasileira, é bastante destacada no setor bancário, comparativamente a outras empresas, o que faz com que seu indicador de RSC total seja superior. No entanto, a situação inverte-se ao se analisar a ação ambiental que é superior para os demais setores. _________________________________________________________________________________ ABSTRACTThis article presents a study on Corporate Social Responsibility (CSR) in Brazilian banks compared to companies in other industries, using data from the Brazilian company’s social actions for the period 1996-2008, based on uni and multivariate analysis. The results on mean comparison showed higher levels of CSR in companies in the banking sector in relation to other segments. Estimating linear regression models the results indicate that the fact that the company is a bank (dummy variable) positively affects the intensity of RSC, controlling for other explanatory variables presented in literature with possible influence over CSR (ROA, growth opportunities, size). Analyzing separately the different strands of social action, one can observe that the internal CSR, the strongest in the Brazilian company, is quite prominent in the banking sector compared to other companies which leads to the superior CSR indicator in the banking segment. However, the situation is reversed when analyzing environmental action that is superior to firms from other sectors

RooStatsCms: a tool for analyses modelling, combination and statistical studies

The RooStatsCms (RSC) software framework allows analysis modelling and combination, statistical studies together with the access to sophisticated graphics routines for results visualisation. The goal of the project is to complement the existing analyses by means of their combination and accurate statistical studies.Comment: Proceedings of the 11th Topical Seminar on Innovative Particle and Radiation Detectors. 4 pages and 5 figure

How useful is the Rehearsal Scale for Children – Chinese in measuring emotional rehearsal in pre-adolescents of different ages?

The Rehearsal Scale for Children – Chinese (RSC-C) measures thepropensity to rehearse emotionally taxing experiences in children,however, the initial development of the scale has overlooked thevalidity of the scale for pre-adolescents of different ages whosecognitive development may differ considerably. Therefore, the aim ofthis study was to explore the internal validity of RSC-C for the differentage groups (aged 6-7, 8-9 and 10-12) across an age range of 6 to12years. Confirmatory factor analysis based on the original factorstructure suggested that the internal validity of the RSC-C is poor andthe scale was modified for the age groups concerned. Test-retest reliability for the modified scales was stronger for the younger age groups and moderate concurrent validity against the Chinese Trait Anxiety Scale for Children (CTAS-C) was established. No gender differences were found. The results highlight the importance of testing the validity of a psychometric instrument across different age ranges, given the potential for significant developmental differences. Thecurrent study also provided a new set of psychometrically sound RSC-C for the different age groups to promote greater understanding of the role of emotional rehearsal and psychological stress in physical and psychological well-being in young children