Recursive Cascaded Networks for Unsupervised Medical Image Registration

We present recursive cascaded networks, a general architecture that enables learning deep cascades, for deformable image registration. The proposed architecture is simple in design and can be built on any base network. The moving image is warped successively by each cascade and finally aligned to the fixed image; this procedure is recursive in a way that every cascade learns to perform a progressive deformation for the current warped image. The entire system is end-to-end and jointly trained in an unsupervised manner. In addition, enabled by the recursive architecture, one cascade can be iteratively applied for multiple times during testing, which approaches a better fit between each of the image pairs. We evaluate our method on 3D medical images, where deformable registration is most commonly applied. We demonstrate that recursive cascaded networks achieve consistent, significant gains and outperform state-of-the-art methods. The performance reveals an increasing trend as long as more cascades are trained, while the limit is not observed. Code is available at https://github.com/microsoft/Recursive-Cascaded-Networks.Comment: Accepted to ICCV 201

CNN-based Lung CT Registration with Multiple Anatomical Constraints

Deep-learning-based registration methods emerged as a fast alternative to conventional registration methods. However, these methods often still cannot achieve the same performance as conventional registration methods because they are either limited to small deformation or they fail to handle a superposition of large and small deformations without producing implausible deformation fields with foldings inside. In this paper, we identify important strategies of conventional registration methods for lung registration and successfully developed the deep-learning counterpart. We employ a Gaussian-pyramid-based multilevel framework that can solve the image registration optimization in a coarse-to-fine fashion. Furthermore, we prevent foldings of the deformation field and restrict the determinant of the Jacobian to physiologically meaningful values by combining a volume change penalty with a curvature regularizer in the loss function. Keypoint correspondences are integrated to focus on the alignment of smaller structures. We perform an extensive evaluation to assess the accuracy, the robustness, the plausibility of the estimated deformation fields, and the transferability of our registration approach. We show that it achieves state-of-the-art results on the COPDGene dataset compared to conventional registration method with much shorter execution time. In our experiments on the DIRLab exhale to inhale lung registration, we demonstrate substantial improvements (TRE below $1.2$ mm) over other deep learning methods. Our algorithm is publicly available at https://grand-challenge.org/algorithms/deep-learning-based-ct-lung-registration/

A Survey on Deep Learning in Medical Image Registration: New Technologies, Uncertainty, Evaluation Metrics, and Beyond

Over the past decade, deep learning technologies have greatly advanced the field of medical image registration. The initial developments, such as ResNet-based and U-Net-based networks, laid the groundwork for deep learning-driven image registration. Subsequent progress has been made in various aspects of deep learning-based registration, including similarity measures, deformation regularizations, and uncertainty estimation. These advancements have not only enriched the field of deformable image registration but have also facilitated its application in a wide range of tasks, including atlas construction, multi-atlas segmentation, motion estimation, and 2D-3D registration. In this paper, we present a comprehensive overview of the most recent advancements in deep learning-based image registration. We begin with a concise introduction to the core concepts of deep learning-based image registration. Then, we delve into innovative network architectures, loss functions specific to registration, and methods for estimating registration uncertainty. Additionally, this paper explores appropriate evaluation metrics for assessing the performance of deep learning models in registration tasks. Finally, we highlight the practical applications of these novel techniques in medical imaging and discuss the future prospects of deep learning-based image registration

Improving Misaligned Multi-modality Image Fusion with One-stage Progressive Dense Registration

Misalignments between multi-modality images pose challenges in image fusion, manifesting as structural distortions and edge ghosts. Existing efforts commonly resort to registering first and fusing later, typically employing two cascaded stages for registration,i.e., coarse registration and fine registration. Both stages directly estimate the respective target deformation fields. In this paper, we argue that the separated two-stage registration is not compact, and the direct estimation of the target deformation fields is not accurate enough. To address these challenges, we propose a Cross-modality Multi-scale Progressive Dense Registration (C-MPDR) scheme, which accomplishes the coarse-to-fine registration exclusively using a one-stage optimization, thus improving the fusion performance of misaligned multi-modality images. Specifically, two pivotal components are involved, a dense Deformation Field Fusion (DFF) module and a Progressive Feature Fine (PFF) module. The DFF aggregates the predicted multi-scale deformation sub-fields at the current scale, while the PFF progressively refines the remaining misaligned features. Both work together to accurately estimate the final deformation fields. In addition, we develop a Transformer-Conv-based Fusion (TCF) subnetwork that considers local and long-range feature dependencies, allowing us to capture more informative features from the registered infrared and visible images for the generation of high-quality fused images. Extensive experimental analysis demonstrates the superiority of the proposed method in the fusion of misaligned cross-modality images