Orthostatic hypotension

Basic orientation of the article, by the leader of a group of medical researchers associated with hospitals in Lyon, France, is toward definition and classification. A table divides OH (orthostatic hypotension) according to physiopathological classification into sympathicotonic and asympathicotonic types and then each of these into primary and secondary with subdivisions. The figure sketches organization and functioning of the baroreflex arc. Applications to clinical study of circulatory reflexes, listing measurement tests and the biological study of hormonal regulation listing the appropriate kinds of studies. Data are not given

New evidence of short-run underpricing in Australian IPOs

The short-run market performance of initial public offerings (IPOs) indicates that the prices are often underpriced. This is widely accepted as a universal phenomenon. To find out whether Australian IPOs are underpriced, this paper analyzes the short-run market performance of 254 IPOs by industry, listing year and issue year. To measure the performance, the first-day returns are divided into the opening price primary market and the closing price secondary market, and the post-listing returns are also examined. The study found that, overall, Australian IPOs were underpriced by 25.47% based on abnormal returns and 26.43% on raw returns on the first-day primary market, which was statistically significant at the 1% level. However, analysis of the secondary market indicates that the Australian IPOs were overpriced by 1.55% and 1.54% on abnormal and raw returns, respectively, which was statistically significant at the 5% level. The examination of post-listing returns shows that Australian IPOs were underpriced based on cumulative abnormal returns (CARs) on the 3rd, 6th, and 10thdays by 24.63%, 24.06%, and 23.34%, respectively. The primary and post-listing analysis shows that IPOs in the industrial sector are more attractive to investors, whereas those in the chemical and materials sector are less attractive compared to other sectors. As far as the investors’ wealth is concerned, the study concludes that the short-run market performance analysis should consider both the first-day and post-listing return

Towards a transparent, credible, evidence-based decision-making process of new drug listing on the Hong Kong Hospital Authority Drug Formulary: challenges and suggestions

The aim of this article is to describe the process, evaluation criteria, and possible outcomes of decision-making for new drugs listed in the Hong Kong Hospital Authority Drug Formulary in comparison to the health technology assessment (HTA) policy overseas. Details of decision-making processes including the new drug listing submission, Drug Advisory Committee (DAC) meeting, and procedures prior to and following the meeting, were extracted from the official Hong Kong Hospital Authority drug formulary management website and manual. Publicly-available information related to the new drug decision-making process for five HTA agencies [the National Institute of Health and Care Excellence (NICE), the Scottish Medicines Consortium (SMC), the Australia Pharmaceutical Benefits Advisory Committee (PBAC), the Canadian Agency for Drugs and Technologies in Health (CADTH), and the New Zealand Pharmaceutical Management Agency (PHARMAC)] were reviewed and retrieved from official documents from public domains. The DAC is in charge of systemically and critically appraising new drugs before they are listed on the formulary, reviewing submitted applications, and making the decision to list the drug based on scientific evidence to which safety, efficacy, and cost-effectiveness are the primary considerations. When compared with other HTA agencies, transparency of the decision-making process of the DAC, the relevance of clinical and health economic evidence, and the lack of health economic and methodological input of submissions are the major challenges to the new-drug listing policy in Hong Kong. Despite these challenges, this review provides suggestions for the establishment of a more transparent, credible, and evidence-based decision-making process in the Hong Kong Hospital Authority Drug Formulary. Proposals for improvement in the listing of new drugs in the formulary should be a priority of healthcare reforms

Summary of studies for a solar optical telescope in space: 1968-1976

The primary objective of this review is to tabulate the basic recommendations of several solar telescope studies. A primary matrix, listing some of the basic optical parameters, was compiled and forms the basis for a table. From this table it is apparent that a strong consensus exists on the configuration of the telescope and on its fundamental dimensionless parameters. Other tables presented in this document address the basic approach of each study to the telescope design as well as to the design of critical subsystems. These subsystem problems include the material, coating, configuration, mounting, launch locks, and thermal control of the primary mirror, the structure of the main telescope and the instrument bay, the mechanisms for radiation rejection, thermal control, and meteoroid shielding, and methods of maintaining image quality by proper alignment and by image motion compensation

Caring for Caregivers: Addressing Caregiver Burden in Newtown, Connecticut

In 2015, thirty-four million Americans provided unpaid care to an adult 50 years or older. Due to an aging population and an increased number of individuals living with chronic disease, the niche that caregivers occupy in healthcare administration will only become more invaluable in the coming years. However, studies demonstrate that one-third of caregivers report a high burden of care, and these stresses are accompanied by documented health risks including higher rates of depression, insomnia, and all-cause mortality. This project aims to increase awareness about caregiver burden via a pamphlet for caregivers listing local resources that may alleviate burden, and a presentation to healthcare providers at Newtown Primary Care.https://scholarworks.uvm.edu/fmclerk/1343/thumbnail.jp

The Impacts of Contract Type on Broker Performance: Submarket Effects

Rutherford et al. (2001) develop and empirically test a model that analyzes the effect the type of listing contract, either exclusive agency (EA) or exclusive right to sell (ERTS), has on the performance of the agent/broker. This paper extends the work of Rutherford et al. (2001) and looks at differences between housing submarkets delineated by price. The results show a selling price discount associated with both broker-effected and owner-effected sales for lower-priced houses with EA contracts. For higher-priced houses, there is no price advantage to an EA-listing if the broker achieves the sale, but if the owner sells the house, there is a modest price premium associated with the sale. The primary implication of the results is that owners of lower-priced houses should be wary of alternative listing arrangements, namely exclusive agency contracts.

High Temperature Composite Analyzer (HITCAN) Programmer's Manual. Version 1.0

This manual describes the organization and flow of data and analysis modules in the computer code, HITCAN (High Temperature Composite ANalyzer). HITCAN is a general purpose computer program for predicting nonlinear global structural and local stress-strain response of arbitrarily oriented, multilayered high temperature metal matrix composite structures. This manual describes the architecture of the HITCAN code, followed by the listing of subroutines and calling tree, data storage scheme, file system, and a dictionary of code terminology. The primary intention of the manual is to familiarize the user with some of the computer program related issues so as to facilitate maintenance/modification/updates of the HITCAN computer code

COSEE-West Ocean Sciences Field Trip Guide (PDF)

This 21 page guide highlights field trip sites between San Diego and Santa Cruz, California; California environmental organizations and programs (entire state); and a special section on California wetlands (entire state). Each field trip listing includes the site name, contact information, and a description of the site and the programs if offers. Educational levels: Primary elementary, Intermediate elementary, Middle school, High school, Undergraduate lower division, Undergraduate upper division, Graduate or professional, General public

Patients Evaluated for Liver Transplant: Transplant List Denial and Subsequent Outcomes

Background: The evaluation process for listing a patient on the liver transplant list is complicated and involves multiple consultations from various specialists, as well as extensive imaging and physiological studies. Although there are data on the outcomes of those listed, we know little about those that are denied listing. This research project will identify the reasons for liver transplant listing denial and predictors of death following denial for this challenging group of patients. Methods: Data from all patients (n=1,500) evaluated for a liver transplant from 1997 to 2007 by the Department of Gastroenterology, Hepatology, and Nutrition located at Virginia Commonwealth University Health System’s (VCUHS) Hume-Lee Transplant Program were reviewed to identify patients denied listing (n=350). Simple descriptive characteristics were generated and the reasons for denial were assessed. The Social Security Death Index was used to determine and/or confirm mortality and multiple logistic regression was conducted to determine the predictors of death following denial of transplant listing. Results: The majority of the denied patients were white males and the mean age was 50.9, SE= 0.542). The primary liver disease diagnosis for those denied listing was Hepatitis C Virus (HCV) (33.6%). Study participants whose primary diagnosis was ethyl alcohol abuse or hepatocellular carcinoma had greater odds of dying after not being listed when compared to those diagnosed with HCV; however, these findings were not statistically significant. The majority of participants were denied listing for Hepatic-related (38.8%), psychosocial-related (21.7%), and cardiac-related (15.7%) reasons. Men were two times more likely to die after denial than women (OR= 2.18, CI= 1.03, 4.62). Patients with a MELD score less than 30 were less likely to die after being denied listing compared to those with MELD scores 31 to 40. The risk of dying after denial was not statistically different for patients who were denied listing for hepatic-related and cardiac-related reasons compared to subjects who were denied for cancer. Conclusions: Our findings have clear implications for the future of transplant medicine and raise additional questions. The analysis shows men, those 51 years of age and older and patients with MELD scores between 31 and 40 are more likely to die after not being listed for transplant. We did not find significant evidence that those with particular primary liver disease diagnoses were more likely to die following denial for listing. Other studies taking into account the population of patients that are listed as well as those denied listing are necessary in order to understand the patho-physiological mechanisms so that patient-specific therapies may be developed if appropriate