9,179 research outputs found
Recommended from our members
The Computational Diet: A Review of Computational Methods Across Diet, Microbiome, and Health.
Food and human health are inextricably linked. As such, revolutionary impacts on health have been derived from advances in the production and distribution of food relating to food safety and fortification with micronutrients. During the past two decades, it has become apparent that the human microbiome has the potential to modulate health, including in ways that may be related to diet and the composition of specific foods. Despite the excitement and potential surrounding this area, the complexity of the gut microbiome, the chemical composition of food, and their interplay in situ remains a daunting task to fully understand. However, recent advances in high-throughput sequencing, metabolomics profiling, compositional analysis of food, and the emergence of electronic health records provide new sources of data that can contribute to addressing this challenge. Computational science will play an essential role in this effort as it will provide the foundation to integrate these data layers and derive insights capable of revealing and understanding the complex interactions between diet, gut microbiome, and health. Here, we review the current knowledge on diet-health-gut microbiota, relevant data sources, bioinformatics tools, machine learning capabilities, as well as the intellectual property and legislative regulatory landscape. We provide guidance on employing machine learning and data analytics, identify gaps in current methods, and describe new scenarios to be unlocked in the next few years in the context of current knowledge
Budget-Constrained Item Cold-Start Handling in Collaborative Filtering Recommenders via Optimal Design
It is well known that collaborative filtering (CF) based recommender systems
provide better modeling of users and items associated with considerable rating
history. The lack of historical ratings results in the user and the item
cold-start problems. The latter is the main focus of this work. Most of the
current literature addresses this problem by integrating content-based
recommendation techniques to model the new item. However, in many cases such
content is not available, and the question arises is whether this problem can
be mitigated using CF techniques only. We formalize this problem as an
optimization problem: given a new item, a pool of available users, and a budget
constraint, select which users to assign with the task of rating the new item
in order to minimize the prediction error of our model. We show that the
objective function is monotone-supermodular, and propose efficient optimal
design based algorithms that attain an approximation to its optimum. Our
findings are verified by an empirical study using the Netflix dataset, where
the proposed algorithms outperform several baselines for the problem at hand.Comment: 11 pages, 2 figure
Machine Learning and Integrative Analysis of Biomedical Big Data.
Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues
Next challenges for adaptive learning systems
Learning from evolving streaming data has become a 'hot' research topic in the last decade and many adaptive learning algorithms have been developed. This research was stimulated by rapidly growing amounts of industrial, transactional, sensor and other business data that arrives in real time and needs to be mined in real time. Under such circumstances, constant manual adjustment of models is in-efficient and with increasing amounts of data is becoming infeasible. Nevertheless, adaptive learning models are still rarely employed in business applications in practice. In the light of rapidly growing structurally rich 'big data', new generation of parallel computing solutions and cloud computing services as well as recent advances in portable computing devices, this article aims to identify the current key research directions to be taken to bring the adaptive learning closer to application needs. We identify six forthcoming challenges in designing and building adaptive learning (pre-diction) systems: making adaptive systems scalable, dealing with realistic data, improving usability and trust, integrat-ing expert knowledge, taking into account various application needs, and moving from adaptive algorithms towards adaptive tools. Those challenges are critical for the evolving stream settings, as the process of model building needs to be fully automated and continuous.</jats:p
- β¦