Transient limb ischemia induces remote ischemic preconditioning in vivo

Background-Ischemic preconditioning reduces local tissue injury caused by subsequent ischemia-reperfusion (IR), but may also have a salutary effect on IR injury of tissues remote from those undergoing preconditioning. We tested the hypothesis that limb ischemia induces remote preconditioning, reduces endothelial IR injury in humans, and reduces experimental myocardial infarct size.Methods and Results-Endothelial IR injury of the human forearm was induced by 20 minutes of upper limb ischemia (inflation of a blood pressure cuff to 200 mm Hg) followed by reperfusion. Remote preconditioning was induced by three 5-minute cycles of ischemia of the contralateral limb. Venous occlusion plethysmography was used to assess forearm blood flow in response to acetylcholine at baseline and 15 minutes after reperfusion. Experimental myocardial infarction was achieved by 40 minutes of balloon occlusion of the left anterior descending artery in 15-kg pigs. Remote preconditioning was induced by four 5-minute cycles of lower limb ischemia. Triphenyltetrazolium staining was used to assess the extent of myocardial infarction. In the human study, the response to acetylcholine was significantly attenuated in the control group after 15 minutes' reperfusion, but remote preconditioning prevented this reduction. Limb ischemia caused a significant reduction in the extent of myocardial infarction relative to the area at risk compared with control (26 +/- 9% versus 53 +/- 8%, P < 0.05).Conclusion-Remote ischemic preconditioning prevents IR-induced endothelial dysfunction in humans and reduces the extent of myocardial infarction in experimental animals. Transient limb ischemia is a simple preconditioning stimulus with important potential clinical applications

Preconditioning Maximal Center Gauge with Stout Link Smearing in SU(3)

Center vortices are studied in SU(3) gauge theory using Maximal Center Gauge (MCG) fixing. Stout link smearing and over-improved stout link smearing are used to construct a preconditioning gauge field transformation, applied to the original gauge field before fixing to MCG. We find that preconditioning successfully achieves higher gauge fixing maxima. We observe a reduction in the number of identified vortices when preconditioning is used, and also a reduction in the vortex-only string tension.Comment: 9 pages, 4 figure

A discretisation method with the HdivH_{\rm div} inner product for electric field integral equations

A discretisation method with the $H_{\rm div}$ inner product for the electric field integral equation~(EFIE) is proposed. The EFIE with the conventional Galerkin discretisation shows bad accuracy for problems with a small frequency, a problem known as the low-frequency breakdown. The discretisation method proposed in this paper utilises the $H_{\rm div}$ scalar product with a scalar coefficient for the Galerkin discretisation and overcomes the low-frequency problem with an appropriately chosen coefficient. As regards the preconditioning, we find that a naive use of the widely-used Calderon preconditioning is not efficient for reducing the computational time with the new discretisation. We therefore propose a new preconditioning which can accelerate the computation successfully. The efficiency of the proposed discretisation and preconditioning is verified through some numerical examples

SSOR Preconditioning of Improved Actions

We generalize local lexicographic SSOR preconditioning for the Sheikholeslami-Wohlert improved Wilson fermion action and the truncated perfect free fermion action. In our test implementation we achieve performance gains as known from SSOR preconditioning of the standard Wilson fermion action.Comment: 3 pages, Latex, 3 figures, Talk presented at Lattice'9

PRECONDITIONING BEEF CALVES: ARE EXPECTED PREMIUMS SUFFICIENT TO JUSTIFY THE PRACTICE?

The concept of preconditioning calves has been around for a long time, yet adoption of the practice has been slow. Current trends in the beef industry likely will increase interest in preconditioning programs. This research estimates premiums received for preconditioned calves and the expected returns from a preconditioning program. Preconditioned calves sold in the fall received a premium of approximately $4.50-$5.50/cwt relative to non-preconditioned calves. Premiums were lower for calves sold in the winter, heavier calves, and when cattle markets were strong. Based on a 45-day post-weaning preconditioning program, cow-calf producers can increase returns about $14/head compared to selling calves at weaning.Livestock Production/Industries,

Calf health and performance during receiving is not changed by fence-line preconditioning on flint hills range vs. drylot preconditioning

Ranch-of-origin preconditioning can improve the welfare and performance of beef calves by decreasing the stress associated with weaning, transport, diet change, and commingling with other calves. Preconditioning methods that involve pasture weaning coupled with maternal contact (i.e., fence-line weaning) have been promoted as possible best management practices for minimizing stress. Prior studies focused on performance and behavior during preconditioning on the ranch of origin. Little information has been published relating to carryover effects of fence-line preconditioning compared with conventional drylot preconditioning on performance and behavior during feedlot receiving. Our objectives were to measure growth and health during a 28-day ranch-of-origin preconditioning phase and during a 60-day feedlot receiving phase among beef calves subjected to 1 of 3 ranch-of-origin preconditioning programs: (1) drylot preconditioning + dam separation, (2) pasture preconditioning + fence-line contact with dams, and (3) pasture preconditioning + fence-line contact with dams + supplemental feed delivered in a bunk. In addition, we recorded incidences of behavioral distress among these treatments during first 7 days of feedlot receiving

Shampoo: Preconditioned Stochastic Tensor Optimization

Preconditioned gradient methods are among the most general and powerful tools in optimization. However, preconditioning requires storing and manipulating prohibitively large matrices. We describe and analyze a new structure-aware preconditioning algorithm, called Shampoo, for stochastic optimization over tensor spaces. Shampoo maintains a set of preconditioning matrices, each of which operates on a single dimension, contracting over the remaining dimensions. We establish convergence guarantees in the stochastic convex setting, the proof of which builds upon matrix trace inequalities. Our experiments with state-of-the-art deep learning models show that Shampoo is capable of converging considerably faster than commonly used optimizers. Although it involves a more complex update rule, Shampoo's runtime per step is comparable to that of simple gradient methods such as SGD, AdaGrad, and Adam

Remote preconditioning by aortic constriction: affords cardioprotection as classical or other remote ischemic preconditioning? Role of iNOS

Dose remote preconditioning by aortic constriction (RPAC) affords cardioprotection similar to classical or other remote ischemic preconditioning stimulus? Moreover study was also designed to investigate role of inducible nitric oxide synthase in remote preconditioning by aortic constriction. There are sufficient evidences that &#x22;ischemic preconditioning&#x22; has surgical applications and afford clinically relevant cardioprotection. Transient occlusion of circumflex artery, renal artery, limb artery or mesenteric artery preconditions the myocardium against ischemia reperfusion injury in case of ischemic heart disease leading to myocardial infraction. Here abdominal aorta was selected to produce RPAC. Four episodes of Ischemia-reperfusion of 5 min each to abdominal aorta produced RPAC by assessment of infract size, LDH and CK. These studies suggest RPAC produced acute (FWOP) and delayed (SWOP) cardioprotective effect. RPAC demonstrated a significant decrease in Ischemia-reperfusion induced release of LDH, CK and extent of myocardial infract size. L-NAME (10 mg/Kg i.v.), Aminoguanidine (150 mg/Kg s.c.), Aminoguanidine (300 mg/Kg s.c.), S-methyl isothiourea (3 mg/Kg i.v.), 1400W (1 mg/Kg i.v.) administered 10 min. before global ischemia reperfusion produced no marked effect. Aminoguanidine (150 mg/Kg s.c.), Aminoguanidine (300 mg/Kg s.c.), S-methyl isothiourea (3 mg/Kg i.v.), 1400W (1 mg/Kg i.v.) pretreatment after RPAC produced no significant effect on acute RPAC induced decrease in LDH, CK and infract size, whereas L-NAME (10 mg/Kg i.v.) increased RPAC induced decrease in LDH, CK and infract size. Most interesting observation is in delayed RPAC, where all NOS inhibitors pretreatment attenuate RPAC induced decrease in LDH, CK and infract size. In conclusions, &#x22;Remote preconditioning by aortic constriction&#x22; (RPAC) affords cardioprotection similar to classical or other remote ischemic preconditioning stimulus. Moreover, late or delayed phase of RPAC has been mediated by inducible nitric oxide synthase (iNOS) whereas it has not involved in acute RPAC