Expression of plasma prekallikrein mRNA in human nonhepatic tissues and cell lineages suggests special local functions of the enzyme

At present it is generally accepted that plasma prekallikrein (PPK) is synthesized in the liver and secreted into the bloodstream. Surprisingly, it has recently been shown that PPK mRNA is present also in RNA from the kidney, adrenal gland and placenta. In spite of its novelty and possible important physiological implications this finding has been neglected. Here we report that PPK mRNA is expressed also in the human brain, heart, lung, trachea, endothelial cells and leukocytes as well as in a variety of fibroblast and epithelial cell lines. Expression of PPK mRNA in fibroblasts, endothelial cells and leukocytes suggests that PPK mRNA detected in RNA preparations from whole tissue may originate solely from these ubiquitously occurring cells. However, PPK mRNA expression in various epithelial cell lines demonstrates that tissue-specific cells also transcribe the PPK gene. The presence of PPK mRNA in nonhepatic tissues and cells indicates that they have the capacity to synthesize the protein. The physiological role of PPK synthesized in extrahepatic tissue is unknown. It may participate in local actions within tissues as well as contributing to the PPK pool in blood plasma. Cultured cells will provide a valuable model for exploring the physiological significance of extrahepatic PPK expression

Modul pelatihan penguatan pendidikan karakter bagi komite sekolah

Buku ini secara garis besar membahas tentang pendidikan karakter di sekolah khususnya bagi komite sekolah yang berisi 6 modul dengan poin-poin pembasannya antara lain : Kebijakan konsep dasar PPK, PPK Berbasis Kelas, PPK Berbasis Budaya Sekolah, PPK Berbasis Budaya Masyarakat, Panduan Penilaian PPK, Desain Rencana Tindak Lanjut

ppK- bound states from Skyrmions

The bound kaon approach to the strangeness in the Skyrme model is applied to investigating the possibility of deeply bound $ppK^-$ states. We describe the $ppK^-$ system as two-Skyrmion around which a kaon field fluctuates. Each Skyrmion is rotated in the space of SU(2) collective coordinate. The rotational motions are quantized to be projected onto the spin-singlet proton-proton state. We derive the equation of motion for the kaon in the background field of two Skyrmions at fixed positions. From the numerical solution of the equation of motion, it is found that the energy of $K^-$ can be considerably small, and that the distribution of $K^-$ shows molecular nature of the $ppK^-$ system. For this deep binding, the Wess-Zumino-Witten term plays an important role. The total energy of the $ppK^-$ system is estimated in the Born-Oppenheimer approximation. The binding energy of the $ppK^-$ state is $B.E.\simeq 126$ MeV. The mean square radius of the $pp$ subsystem is $\sqrt{}\simeq 1.6$ fm.Comment: Oct 2007, 15 pages, 8 figures; added references, corrected typo

Analysis of the differential cross sections for the reaction pp --> ppK+K- in view of the K+K- interaction

Measurements of the pp-->ppK+K- reaction, performed with the experiment COSY-11 at the Cooler Synchrotron COSY, show a significant difference between the obtained excitation function and theoretical expectations including pp-FSI >. The discrepancy may be assigned to the influence of K+K- or K-p interaction. This interaction should manifest itself in the distributions of the differential cross section. This thesis presents an analysis of event distributions as a function of the invariant masses of two particle subsystems. In particular in the analysis two generalizations of the Dalitz plot proposed by Goldhaber and Nyborg are used. The present Investigations are based on the experimental data determined by the COSY-11 collaboration from two measurements at excess energies of Q = 10 MeV and 28 MeV. The experimental distributions are compared to results of Monte Carlo simulations generated with various parameters of the K+K- and K-p interaction. The values of the K+K- scattering length, extracted from two data sets for Q = 10 MeV and 28 MeV amount to: a_K+K- = (11 +- 8) + i(0 +- 6) fm for Q = 10 MeV, and a_K+K- = (0.2 +-0.2) + i(0.0 +- 0.5) fm for Q = 28 MeV, Due to the low statistics, the extracted values have large uncertainties and are consistent with very low values of the real and imaginary part of the scattering length.Comment: Master Thesis prepared in the Nuclear Physics Division of the Jagiellonian University; 37 pages, 19 figure

Study of the Low Energy Dynamics in the ppK+K- System with the Cosy-11 Magnetic Spectrometer

The near threshold production of K+K- pairs in proton-proton collisions has been investigated at the cooler synchrotron COSY below and above the threshold for the \phi meson production. The experimental excitation function determined for the pp-->ppK+K- reaction differs from theoretical expectations including proton-proton final state interaction. The discrepancy may be assigned to the influence of K+K- or pK interaction. In this article we present distributions of the cross section for the pp-->ppK+K- reaction as a function of the invariant masses of two and three particle subsystems at excess energies of Q=10 MeV and 28 MeV.Comment: Presented at the Symposium on Meson Physics, Cracow, 01-04 October 200

K−^- Meson Production in the Proton-Proton Reaction at 3.67 GeV/c

The total cross section of the reaction $pp\to ppK^+K^-$ has been determined for proton--proton reactions with $p_{beam}=3.67 GeV/c$. This represents the first cross section measurement of the $pp \to ppK^-K^+$ channel near threshold, and is equivalent to the inclusive $pp\to ppK^-X$ cross section at this beam momentum. The cross section determined at this beam momentum is about a factor 20 lower than that for inclusive $pp\to ppK^+X$ meson production at the same CM energy above the corresponding threshold. This large difference in the $K^+$ and $K^-$ meson inclusive production cross sections in proton-proton reactions is in strong contrast to cross sections measured in sub-threshold heavy ion collisions, which are similar in magnitude at the same energy per nucleon below the respective thresholds.Comment: 12 pages, 3 figures Phys. Lett. B in prin

Phenomenological studies of the low energy dynamics in the ppK+K−ppK^+K^- system

In this article we review studies of the near threshold $pp \to ppK^+K^-$ reaction done with the COSY-11 and ANKE detectors. We discuss phenomenological studies of the $ppK^+K^-$ dynamics, in particular the recent investigations on the $K^+K^-$ final state interaction are presented.Comment: Proceedings of the EFB22 conference (4 pages, 1 figure

On the Cartan matrix of Mackey algebras

Let k be a field of characteristic p>0, and G be a finite group. The first result of this paper is an explicit formula for the determinant of the Cartan matrix of the Mackey algebra mu_k(G) of G over k. The second one is a formula for the rank of the Cartan matrix of the cohomological Mackey algebra comu_k(G) of G over k, and a characterization of the groups G for which this matrix is non singular. The third result is a generalization of this rank formula and characterization to blocks of comu_k(G) : in particular, if b is a block of kG, the Cartan matrix of the corresponding block comu_k(b) of comu_k(G) is non singular if and only if b is nilpotent with cyclic defect groups

Shedding New Light on Kaon-Nucleon/Nuclei Interaction and Its Astrophysical Implications with the AMADEUS Experiment at DAFNE

The AMADEUS experiment deals with the investigation of the low-energy kaon-nuclei hadronic interaction at the DA{\Phi}NE collider at LNF-INFN, which is fundamental to respond longstanding questions in the non-perturbative QCD strangeness sector. The antikaon-nucleon potential is investigated searching for signals from possible bound kaonic clusters, which would open the possibility for the formation of cold dense baryonic matter. The confirmation of this scenario may imply a fundamental role of strangeness in astrophysics. AMADEUS step 0 consisted in the reanalysis of 2004/2005 KLOE dataset, exploiting K- absorptions in H, 4He, 9Be and 12C in the setup materials. In this paper, together with a review on the multi-nucleon K- absorption and the particle identification procedure, the first results on the {\Sigma}0-p channel will be presented including a statistical analysis on the possible accomodation of a deeply bound stateComment: 6 pages, 2 figure, 1 table, HADRON 2015 conferenc