REPP-H: runtime estimation of power and performance on heterogeneous data centers

Modern data centers increasingly demand improved performance with minimal power consumption. Managing the power and performance requirements of the applications is challenging because these data centers, incidentally or intentionally, have to deal with server architecture heterogeneity [19], [22]. One critical challenge that data centers have to face is how to manage system power and performance given the different application behavior across multiple different architectures.This work has been supported by the EU FP7 program (Mont-Blanc 2, ICT-610402), by the Ministerio de Economia (CAP-VII, TIN2015-65316-P), and the Generalitat de Catalunya (MPEXPAR, 2014-SGR-1051). The material herein is based in part upon work supported by the US NSF, grant numbers ACI-1535232 and CNS-1305220.Peer ReviewedPostprint (author's final draft

Emerging technologies for the non-invasive characterization of physical-mechanical properties of tablets

The density, porosity, breaking force, viscoelastic properties, and the presence or absence of any structural defects or irregularities are important physical-mechanical quality attributes of popular solid dosage forms like tablets. The irregularities associated with these attributes may influence the drug product functionality. Thus, an accurate and efficient characterization of these properties is critical for successful development and manufacturing of a robust tablets. These properties are mainly analyzed and monitored with traditional pharmacopeial and non-pharmacopeial methods. Such methods are associated with several challenges such as lack of spatial resolution, efficiency, or sample-sparing attributes. Recent advances in technology, design, instrumentation, and software have led to the emergence of newer techniques for non-invasive characterization of physical-mechanical properties of tablets. These techniques include near infrared spectroscopy, Raman spectroscopy, X-ray microtomography, nuclear magnetic resonance (NMR) imaging, terahertz pulsed imaging, laser-induced breakdown spectroscopy, and various acoustic- and thermal-based techniques. Such state-of-the-art techniques are currently applied at various stages of development and manufacturing of tablets at industrial scale. Each technique has specific advantages or challenges with respect to operational efficiency and cost, compared to traditional analytical methods. Currently, most of these techniques are used as secondary analytical tools to support the traditional methods in characterizing or monitoring tablet quality attributes. Therefore, further development in the instrumentation and software, and studies on the applications are necessary for their adoption in routine analysis and monitoring of tablet physical-mechanical properties

Efficiency and Productivity Analysis in Regulation and Governance

This paper surveys the application of efficiency and productivity analysis to recent regulatory experience, especially in Europe. From a review of regulatory case studies, particularly of network industries, it is clear that regulatory practice differs from theoretical precedent in choice of methodology, sample size, model specification and price or revenue control implementation. A principal-agent model of linear regulatory contracts is used to understand this discrepancy, suggesting that efficiency and productivity analysis has been used to capture economic rent rather than to provide incentives for efficiency. Predictions of the model are used to investigate other assumptions in efficiency and productivity analysis.regulation, data envelopment analysis, stochastic frontier analysis.