Regelungstheorie

The workshop “Regelungstheorie” (control theory) covered a broad variety of topics that were either concerned with fundamental mathematical aspects of control or with its strong impact in various fields of engineering

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

Microphysiological systems (MPSs) are in vitro models that capture facets of in vivo organ function through use of specialized culture microenvironments, including 3D matrices and microperfusion. Here, we report an approach to co-culture multiple different MPSs linked together physiologically on re-useable, open-system microfluidic platforms that are compatible with the quantitative study of a range of compounds, including lipophilic drugs. We describe three different platform designs - "4-way", "7-way", and "10-way" - each accommodating a mixing chamber and up to 4, 7, or 10 MPSs. Platforms accommodate multiple different MPS flow configurations, each with internal re-circulation to enhance molecular exchange, and feature on-board pneumatically-driven pumps with independently programmable flow rates to provide precise control over both intra- and inter-MPS flow partitioning and drug distribution. We first developed a 4-MPS system, showing accurate prediction of secreted liver protein distribution and 2-week maintenance of phenotypic markers. We then developed 7-MPS and 10-MPS platforms, demonstrating reliable, robust operation and maintenance of MPS phenotypic function for 3 weeks (7-way) and 4 weeks (10-way) of continuous interaction, as well as PK analysis of diclofenac metabolism. This study illustrates several generalizable design and operational principles for implementing multi-MPS "physiome-on-a-chip" approaches in drug discovery.United States. Army Research Office (Grant W911NF-12-2-0039

Manufacturing systems considered as time domain control systems : receding horizon control and observers

This thesis considers manufacturing systems and model-based controller design, as well as their combinations. The objective of a manufacturing system is to create products from a selected group of raw materials and semifinished goods. In the field of manufacturing systems control is an important issue appearing at various operation levels. At the level of fabrication, for example, control is necessary in order to assure properly working production processes such that products are being fabricated in the desired way. At a higher level in the hierarchy of manufacturing system control, the product streams through the system are controlled in order to satisfy, for example, customer demands in an optimal way. Here, the definition of optimal can be interpreted in various ways, such as "with the least possible costs in terms of money" or "in the shortest possible time". In this research, the attention is focussed on this higher hierarchy level of manufacturing system control. In the literature, many heuristic methods have been developed for the control of a manufacturing system. Nowadays, some heuristicmethods are still being used in combination with operator experience for management of resources and planning of production. However, as the complexity of the manufacturing systems increases rapidly, the (simple) heuristic methods and operator experience will at some point become incapable of finding an optimal control strategy. In this dissertation the potential of consideringmanufacturing system control from a control systems point of view is investigated. The ultimate goal of the research is to eventually obtain a more constructive way to address controller design for manufacturing systems. One control strategy from control systems theory, on which is in particularly focused in this research, is a model-based receding horizon control strategy, known in literature as Model Predictive Control (MPC). Since in manufacturing systems a lot of physical system constraints are involved, like for example finite machine process capacities, finite product storage capacities, finite product arrival rates, etc., the capability for a manufacturing control strategy to handle those constraints is a necessity. One of the key features of model predictive control is the capability of handling constraints in the controller design. This is one of the major motivations to investigate the model predictive control principle as a control strategy for manufacturing systems. Other issues that are important and that the model predictive control design methodology can handle is to enforce optimality, to introduce feedback, and the capability of allowing for mixed continuous and discrete model structures. The later are typically encountered when models of manufacturing systems are derived. The main results that are obtained in this dissertation and that are relevant in the context of manufacturing systems control, but are certainly also relevant beyond this field are: • One has developed an robust computationally friendly nonlinear model predictive control algorithm that can handle model structures with mixed continuous and discrete dynamics. The algorithm can be designed for additive disturbance rejection purposes; • Robustness (with respect to measurement noise) results that are in particulary of interest in the field of nonlinear model predictive control are obtained; • An asymptotically stabilizing output based nonlinear model predictive control scheme for a class of nonlinear discrete-time systems is developed. Results that are relevant in the context of manufacturing systems control are: • It is illustrated howthe aforementioned developed robust computationally friendly nonlinear model predictive control algorithm can be employed to solve a large scale manufacturing control problem in an efficient decentralized manner; • The relation between the so-called event domain modeling approaches for a class of discrete-eventmanufacturing systems to time domainmodels is derived. This results enables one to solve seemingly untractable time domain formulated optimal control problems for a class of manufacturing systems in a tractable manner; • An observer theory for a class of discrete-event manufacturing systems is developed

Geodupa - a geography-driven partial membership algorithm

Trabalho apresentado no âmbito do Mestrado em Engenharia Informática, como requisito parcial para obtenção do grau de Mestre em Engenharia InformáticaThe popularity boost of mobile devices, as well as their technological advances, are fostering the development of new application paradigms. One of which, designated as Participatory Sensing, is embedded with a strong community philosophy, in the sense that it relies in users sharing and contributing with data. By gathering, processing and sharing contextual data, new and interesting applications are possible, such as the monitoring of vehicle traffic or road conservation. To enable these applications, it is important to have an underlying communication infrastructure that allows users to exchange information efficiently. Users of Participatory Sensing applications deal, most frequently, with information related to their close physical surroundings. Based on this premise, this dissertation presents a decentralized membership substrate that restrains node visibility to geographical neighborhoods as a way to improve communication performance. To that end, the proposed algorithm divides the user network into two hierarchical levels. The higher-level is managed by an existing one-hop DHT and its participants are organized to exploit the partitioning of the physical space. The lower-level is composed by the groups of nodes associated to each region. An experimental evaluation has revealed that it is capable of achieving lower communication costs when compared to a full-membership solution

Autonomic and Apoptotic, Aeronautical and Aerospace Systems, and Controlling Scientific Data Generated Therefrom

A self-managing system that uses autonomy and autonomicity is provided with the self-* property of autopoiesis (self-creation). In the event of an agent in the system self-destructing, autopoiesis auto-generates a replacement. A self-esteem reward scheme is also provided and can be used for autonomic agents, based on their performance and trust. Art agent with greater self-esteem may clone at a greater rate compared to the rate of an agent with lower self-esteem. A self-managing system is provided for a high volume of distributed autonomic/self-managing mobile agents, and autonomic adhesion is used to attract similar agents together or to repel dissimilar agents from an event horizon. An apoptotic system is also provided that accords an "expiry date" to data and digital objects, for example, that are available on the internet, which finds usefulness not only in general but also for controlling the loaning and use of space scientific data