11,670 research outputs found
ICE: Enabling Non-Experts to Build Models Interactively for Large-Scale Lopsided Problems
Quick interaction between a human teacher and a learning machine presents
numerous benefits and challenges when working with web-scale data. The human
teacher guides the machine towards accomplishing the task of interest. The
learning machine leverages big data to find examples that maximize the training
value of its interaction with the teacher. When the teacher is restricted to
labeling examples selected by the machine, this problem is an instance of
active learning. When the teacher can provide additional information to the
machine (e.g., suggestions on what examples or predictive features should be
used) as the learning task progresses, then the problem becomes one of
interactive learning.
To accommodate the two-way communication channel needed for efficient
interactive learning, the teacher and the machine need an environment that
supports an interaction language. The machine can access, process, and
summarize more examples than the teacher can see in a lifetime. Based on the
machine's output, the teacher can revise the definition of the task or make it
more precise. Both the teacher and the machine continuously learn and benefit
from the interaction.
We have built a platform to (1) produce valuable and deployable models and
(2) support research on both the machine learning and user interface challenges
of the interactive learning problem. The platform relies on a dedicated,
low-latency, distributed, in-memory architecture that allows us to construct
web-scale learning machines with quick interaction speed. The purpose of this
paper is to describe this architecture and demonstrate how it supports our
research efforts. Preliminary results are presented as illustrations of the
architecture but are not the primary focus of the paper
Track 3: Computations in theoretical physics -- techniques and methods
Here, we attempt to summarize the activities of Track 3 of the 17th
International Workshop on Advanced Computing and Analysis Techniques in Physics
Research (ACAT 2016).Comment: 10 pages, 3 figures, to appear in the proceedings of ACAT 201
Using the R Package crlmm for Genotyping and Copy Number Estimation
Genotyping platforms such as Affymetrix can be used to assess genotype-phenotype as well as copy number-phenotype associations at millions of markers. While genotyping algorithms are largely concordant when assessed on HapMap samples, tools to assess copy number changes are more variable and often discordant. One explanation for the discordance is that copy number estimates are susceptible to systematic differences between groups of samples that were processed at different times or by different labs. Analysis algorithms that do not adjust for batch effects are prone to spurious measures of association. The R package crlmm implements a multilevel model that adjusts for batch effects and provides allele-specific estimates of copy number. This paper illustrates a workflow for the estimation of allele-specific copy number and integration of the marker-level estimates with complimentary Bioconductor software for inferring regions of copy number gain or loss. All analyses are performed in the statistical environment R.
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