Frontiers of parasitology research in the People's Republic of China : infection, diagnosis, protection and surveillance

ABSTRACT: Control and eventual elimination of human parasitic diseases in the People's Republic of China (P.R. China) requires novel approaches, particularly in the areas of diagnostics, mathematical modelling, monitoring, evaluation, surveillance and public health response. A comprehensive effort, involving the collaboration of 188 scientists (<85% from P.R. China) from 48 different institutions and universities (80% from P.R. China), covers this collection of 29 articles published in Parasites & Vectors. The research mainly stems from a research project entitled 'Surveillance and diagnostic tools for major parasitic diseases in P.R. China' (grant no. 2008ZX10004-011) and highlights the frontiers of research in parasitology. The majority of articles in this thematic series deals with the most important parasitic diseases in P.R. China, emphasizing Schistosoma japonicum, Plasmodium vivax and Clonorchis sinensis plus some parasites of emerging importance such as Angiostrongylus cantonensis. Significant achievements have been made through the collaborative research programme in the following three fields: (i) development of control strategies for the national control programme; (ii) updating the surveillance data of parasitic infections both in human and animals; and (iii) improvement of existing, and development of novel, diagnostic tools to detect parasitic infections. The progress is considerable and warrants broad validation efforts. Combined with the development of improved tools for diagnosis and surveillance, integrated and multi-pronged control strategies now pave the way for elimination of parasitic diseases in P.R. China. Experiences and lessons learned can stimulate control and elimination efforts of parasitic diseases in other parts of the world

Hepatic stellate cells and parasite-induced liver fibrosis

ABSTRACT: Fibrogenesis is a common feature of many diseases where there is severe insult to the liver. The hepatic stellate cell trans-differentiation into a myofibroblast has been identified as an important event in liver fibrogenesis and has been well investigated over the last few years in a number of liver diseases. The trans-differentiation process can be monitored in vitro by evaluation of biomarkers that are characteristic of normal quiescent hepatic stellate cells or activated myofibroblasts. Two major parasitic diseases associated with liver injury and fibrosis are schistosomiasis and echinococcosis. Recent studies have highlighted a role for activated hepatic stellate cells in both murine and human schistosomiasis as well as demonstrating that schistosome antigens are able to regulate this trans-differentiation process. Study of the hepatic stellate cell and its interaction with parasite-derived antigens may be pivotal in our understanding of the pathology associated with schistosomiasis and other parasitic diseases, including echinococcosis, as well as revealing new information on the trans-differentiation process in this cell type

The rule of five should not impede anti-parasitic drug development.

The "rule of 5" has become a mainstay of decision-making in the pharmaceutical industry as well as in nonindustrial (academic and institutional) drug development. However the authors of the original paper never intended for "double cutoffs" to preclude development of new drug leads for parasitic diseases

Parasitic lung diseases (Editorial)

Lung diseases that result from infestations with Pleuropulmonary amoebiasis: protozoal and helminthic parasites are important public health problems worldwide. There is a renewed interest in parasitic lung diseases because of the frequent opportunistic infections especially with Pneumocytis carinii, Toxoplasma gondii and Strongyloides stercoralis in patients suffering from acquired immunodeficiency syndrome (AIDS)

Clinical presentations of viral and parasitic diseases in HIV infection

Представлений аналіз залежності клінічних проявів інфекцій вірусної і паразитарної етіології на тлі ВІЛ-інфекції від рівня CD4-лімфоцитів. При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/26618Представлен анализ зависимости клинических проявлений инфекций вирусной и паразитарной этиологии на фоне ВИЧ-инфекции от уровня CD4-лимфоцитов. При цитировании документа, используйте ссылку http://essuir.sumdu.edu.ua/handle/123456789/26618Represented the analysis of dependence of clinical manifestations of infections with viral and parasitic etiology on the background of HIV infection from the level of CD4-lymphocytes. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/2661

Some biological features of Saprolegnia parasitica Coker - cause of fish dermatomycosis. [Translation from: Pervaya nauchnaya konferentsiya molodykh Uchenykh Biologov (Tezisy Dokladov) pp.84-86. Kiev, A.N.Ukr. SSR., 1964]

Parasitic and infectious diseases of fish, of wide distribution in fish-rearing ponds, retard to a significant extent the development of fish culture in the Ukraine. One of the diseases of fish attracting attention in connection with the general distribution of its causative agent, the fungus Saprolegnia parasitica Coker, in water-bodies of various types, appears to be dermatomycosis. The aim of this investigation is to study the conditions favouring the development of S. parasitica. Among the studied factors were water temperature and oxygen content

Report on the mission to SIAT Gabon, 7 to 19 December 2006

The purpose of the mission was to make a phytosanitary inspection of the Mitzic estate, make recommendations for controlling leaf diseases, draw up an experimental protocol for ULV defoliant treatment and propose a system of general foliage monitoring at the estate. In addition to those recommendations, the expert proposed that a clone trial be resumed and touched upon "parasitic phanerogams" and root diseases (with a view to new plantations), but no experimental protocol was set in place for those subjects. The expert will ensure scientific monitoring of the trials set up. Two other missions have been requested by SIAT in 2007

Parasitic Diseases in a Boarding School Children in Bogor Regency

InductionThis study was aimed to determine the prevalence of parasitic diseases in boarding school children followed by eradication. Parasites consist of ecto and endo parasites. This study was conducted in Daarul Mustaqiem Boarding School, Pamijahan Village, Bogor Recency on May 2018 with the subject of all students. Diagnosis of intestinal parasite was done by microscopic stool examination with lugol staining while diagnosis of pediculosis and scabies by dermatological examination. The number of students attending the parasitic examination from PAUD to Aliyah was 501 students. Based on stool examination, the prevalence of intestinal parasitic infections was 57%. The most parasitic infections are B. hominis (128 students), followed by G. lamblia (13 students) and O. vermicularis (6 students). Students with positive worms were treated with albendazole 400 mg three days in a row and positive protozoa was treated with metronidazole. As many as 107 of the 121 (88.4%) students found live head lice. Students who are positive for pediculosis are treated with permethrin 1%. On examination of 159 male students, the prevalence of scabies was (7.5%). Students positive for scabies were treated with permethrin cream 5%. It was concluded that the prevalence of intestinal parasitic infections in santri was 59.4% with the highest infection in B. hominis; other intestinal parasites was relatively low. The prevalence of pediculosis capitis in female student was very high (88.4%) and the prevalence of scabies is low. All children treated according to the diagnosis and followed by health education on parasitic diseases and healthy hygiene behavior