20,831 research outputs found
Orientation and anisotropy of multi-component shapes from boundary information
We define a method for computing the orientation of compound shapes based on boundary information. The orientation of a given compound shape S is taken as the direction α that maximises the integral of the squared length of projections, of all the straight line segments whose end points belong to particular boundaries of components of S to a line that has the slope α. Just as the concept of orientation can be extended from single component shapes to multiple components, elongation can also be applied to multiple components, and we will see that it effectively produces a measure of anisotropy since it is maximised when all components are aligned in the same direction. The presented method enables a closed formula for an easy computation of both orientation and anisotropy
Structural characterization and statistical-mechanical model of epidermal patterns
In proliferating epithelia of mammalian skin, cells of irregular
polygonal-like shapes pack into complex nearly flat two-dimensional structures
that are pliable to deformations. In this work, we employ various sensitive
correlation functions to quantitatively characterize structural features of
evolving packings of epithelial cells across length scales in mouse skin. We
find that the pair statistics in direct and Fourier spaces of the cell
centroids in the early stages of embryonic development show structural
directional dependence, while in the late stages the patterns tend towards
statistically isotropic states. We construct a minimalist four-component
statistical-mechanical model involving effective isotropic pair interactions
consisting of hard-core repulsion and extra short-ranged soft-core repulsion
beyond the hard core, whose length scale is roughly the same as the hard core.
The model parameters are optimized to match the sample pair statistics in both
direct and Fourier spaces. By doing this, the parameters are biologically
constrained. Our model predicts essentially the same polygonal shape
distribution and size disparity of cells found in experiments as measured by
Voronoi statistics. Moreover, our simulated equilibrium liquid-like
configurations are able to match other nontrivial unconstrained statistics,
which is a testament to the power and novelty of the model. We discuss ways in
which our model might be extended so as to better understand morphogenesis (in
particular the emergence of planar cell polarity), wound-healing, and disease
progression processes in skin, and how it could be applied to the design of
synthetic tissues
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