Properties and constructions of constrained codes for DNA-based data storage

We describe properties and constructions of constraint-based codes for DNA-based data storage which account for the maximum repetition length and AT/GC balance. We present algorithms for computing the number of sequences with maximum repetition length and AT/GC balance constraint. We describe routines for translating binary runlength limited and/or balanced strings into DNA strands, and compute the efficiency of such routines. We show that the implementation of AT/GC-balanced codes is straightforward accomplished with binary balanced codes. We present codes that account for both the maximum repetition length and AT/GC balance. We compute the redundancy difference between the binary and a fully fledged quaternary approach

Deep Learning-Based Decoding of Constrained Sequence Codes

Constrained sequence (CS) codes, including fixed-length CS codes and variable-length CS codes, have been widely used in modern wireless communication and data storage systems. Sequences encoded with constrained sequence codes satisfy constraints imposed by the physical channel to enable efficient and reliable transmission of coded symbols. In this paper, we propose using deep learning approaches to decode fixed-length and variable-length CS codes. Traditional encoding and decoding of fixed-length CS codes rely on look-up tables (LUTs), which is prone to errors that occur during transmission. We introduce fixed-length constrained sequence decoding based on multiple layer perception (MLP) networks and convolutional neural networks (CNNs), and demonstrate that we are able to achieve low bit error rates that are close to maximum a posteriori probability (MAP) decoding as well as improve the system throughput. Further, implementation of capacity-achieving fixed-length codes, where the complexity is prohibitively high with LUT decoding, becomes practical with deep learning-based decoding. We then consider CNN-aided decoding of variable-length CS codes. Different from conventional decoding where the received sequence is processed bit-by-bit, we propose using CNNs to perform one-shot batch-processing of variable-length CS codes such that an entire batch is decoded at once, which improves the system throughput. Moreover, since the CNNs can exploit global information with batch-processing instead of only making use of local information as in conventional bit-by-bit processing, the error rates can be reduced. We present simulation results that show excellent performance with both fixed-length and variable-length CS codes that are used in the frontiers of wireless communication systems.Comment: 12 pages, 9 figures, accepted by IEEE Journal on Selected Areas in Communications (JSAC) - Machine Learning in Wireless Communications. arXiv admin note: substantial text overlap with arXiv:1809.0185