Comparison of Path Tracking Flat Control and Working Point Linearization Based Set Point Control of Tumor Growth with Angiogenic Inhibition

Targeted molecular therapies (TMT) represent new perspectives in cancer treatment, fighting against the specific characteristic of the investigated tumor. Antiangiogenic therapy represents a specific TMT and its role is to stop the angiogenesis of the tumor, the process of forming new blood vessels; hence, to stop tumor growth. Proper control algorithms for tumor growth control with angiogenic inhibition are analyzed in the current article in order to find optimal therapeutic protocols. Two slightly different approaches are compared: nonlinear control by exact linearization with path tracking control, and linear control by working point linearization with set point control. The control strategies are compared in terms of the characteristics of the input signal (the inhibitor, drug intake) that is crucial if the therapy will be put into practice

1-Bit processing based model predictive control for fractionated satellite missions

In this thesis, a 1-bit processing based Model Predictive Control (OBMPC) structure is proposed for a fractionated satellite attitude control mission. Despite the appealing advantages of the MPC algorithm towards constrained MIMO control applications, implementing the MPC algorithm onboard a small satellite is certainly challenging due to the limited onboard resources. The proposed design is based on the 1-bit processing concept, which takes advantage of the affine relation between the 1-bit state feedback and multi-bit parameters to implement a multiplier free MPC controller. As multipliers are the major power consumer in online optimization, the OBMPC structure is proven to be more efficient in comparison to the conventional MPC implementation in term of power and circuit complexity. The system is in digital control nature, affected by quantization noise introduced by Δ∑ modulators. The stability issues and practical design criteria are also discussed in this work. Some other aspects are considered in this work to complete the control system. Firstly, the implementation of the OBMPC system relies on the 1-bit state feedbacks. Hence, 1-bit sensing components are needed to implement the OBMPC system. While the ∆∑ modulator based Microelectromechanical systems (MEMS) gyroscope is considered in this work, it is possible to implement this concept into other sensing components. Secondly, as the proposed attitude mission is based on the wireless inter-satellite link (ISL), a state estimator is required. However, conventional state estimators will once again introduce multi-bit signals, and compromise the simple, direct implementation of the OBMPC controller. Therefore, the 1-bit state estimator is also designed in this work to satisfy the requirements of the proposed fractionated attitude control mission. The simulation for the OBMPC is based on a 2U CubeSat model in a fractionated satellite structure, in which the payload and actuators are separated from the controller and controlled via the ISL. Matlab simulations and FPGA implementation based performance analysis shows that the OBMPC is feasible for fractionated satellite missions and is advantageous over the conventional MPC controllers

1-Bit processing based model predictive control for fractionated satellite missions

In this thesis, a 1-bit processing based Model Predictive Control (OBMPC) structure is proposed for a fractionated satellite attitude control mission. Despite the appealing advantages of the MPC algorithm towards constrained MIMO control applications, implementing the MPC algorithm onboard a small satellite is certainly challenging due to the limited onboard resources. The proposed design is based on the 1-bit processing concept, which takes advantage of the affine relation between the 1-bit state feedback and multi-bit parameters to implement a multiplier free MPC controller. As multipliers are the major power consumer in online optimization, the OBMPC structure is proven to be more efficient in comparison to the conventional MPC implementation in term of power and circuit complexity. The system is in digital control nature, affected by quantization noise introduced by Δ∑ modulators. The stability issues and practical design criteria are also discussed in this work. Some other aspects are considered in this work to complete the control system. Firstly, the implementation of the OBMPC system relies on the 1-bit state feedbacks. Hence, 1-bit sensing components are needed to implement the OBMPC system. While the ∆∑ modulator based Microelectromechanical systems (MEMS) gyroscope is considered in this work, it is possible to implement this concept into other sensing components. Secondly, as the proposed attitude mission is based on the wireless inter-satellite link (ISL), a state estimator is required. However, conventional state estimators will once again introduce multi-bit signals, and compromise the simple, direct implementation of the OBMPC controller. Therefore, the 1-bit state estimator is also designed in this work to satisfy the requirements of the proposed fractionated attitude control mission. The simulation for the OBMPC is based on a 2U CubeSat model in a fractionated satellite structure, in which the payload and actuators are separated from the controller and controlled via the ISL. Matlab simulations and FPGA implementation based performance analysis shows that the OBMPC is feasible for fractionated satellite missions and is advantageous over the conventional MPC controllers

Gauge Theory for Finite-Dimensional Dynamical Systems

Gauge theory is a well-established concept in quantum physics, electrodynamics, and cosmology. This theory has recently proliferated into new areas, such as mechanics and astrodynamics. In this paper, we discuss a few applications of gauge theory in finite-dimensional dynamical systems with implications to numerical integration of differential equations. We distinguish between rescriptive and descriptive gauge symmetry. Rescriptive gauge symmetry is, in essence, re-scaling of the independent variable, while descriptive gauge symmetry is a Yang-Mills-like transformation of the velocity vector field, adapted to finite-dimensional systems. We show that a simple gauge transformation of multiple harmonic oscillators driven by chaotic processes can render an apparently "disordered" flow into a regular dynamical process, and that there exists a remarkable connection between gauge transformations and reduction theory of ordinary differential equations. Throughout the discussion, we demonstrate the main ideas by considering examples from diverse engineering and scientific fields, including quantum mechanics, chemistry, rigid-body dynamics and information theory

Application of robust control in unmanned vehicle flight control system design

The robust loop-shaping control methodology is applied in the flight control system design of the Cranfield A3 Observer unmanned, unstable, catapult launched air vehicle. Detailed linear models for the full operational flight envelope of the air vehicle are developed. The nominal and worst-case models are determined using the v-gap metric. The effect of neglecting subsystems such as actuators and/or computation delays on modelling uncertainty is determined using the v-gap metric and shown to be significant. Detailed designs for the longitudinal, lateral, and the combined full dynamics TDF controllers were carried out. The Hanus command signal conditioning technique is also implemented to overcome actuator saturation and windup. The robust control system is then successfully evaluated in the high fidelity 6DOF non-linear simulation to assess its capability of launch stabilization in extreme cross-wind conditions, control effectiveness in climb, and navigation precision through the prescribed 3D flight path in level cruise. Robust performance and stability of the single-point non-scheduled control law is also demonstrated throughout the full operational flight envelope the air vehicle is capable of and for all flight phases and beyond, to severe launch conditions, such as 33knots crosswind and exaggerated CG shifts. The robust TDF control law is finally compared with the classical PMC law where the actual number of variables to be manipulated manually in the design process are shown to be much less, due to the scheduling process elimination, although the size of the final controller was much higher. The robust control law performance superiority is demonstrated in the non-linear simulation for the full flight envelope and in extreme flight conditions