Learning Optimal Deep Projection of 18^{18}F-FDG PET Imaging for Early Differential Diagnosis of Parkinsonian Syndromes

Several diseases of parkinsonian syndromes present similar symptoms at early stage and no objective widely used diagnostic methods have been approved until now. Positron emission tomography (PET) with $^{18}$F-FDG was shown to be able to assess early neuronal dysfunction of synucleinopathies and tauopathies. Tensor factorization (TF) based approaches have been applied to identify characteristic metabolic patterns for differential diagnosis. However, these conventional dimension-reduction strategies assume linear or multi-linear relationships inside data, and are therefore insufficient to distinguish nonlinear metabolic differences between various parkinsonian syndromes. In this paper, we propose a Deep Projection Neural Network (DPNN) to identify characteristic metabolic pattern for early differential diagnosis of parkinsonian syndromes. We draw our inspiration from the existing TF methods. The network consists of a (i) compression part: which uses a deep network to learn optimal 2D projections of 3D scans, and a (ii) classification part: which maps the 2D projections to labels. The compression part can be pre-trained using surplus unlabelled datasets. Also, as the classification part operates on these 2D projections, it can be trained end-to-end effectively with limited labelled data, in contrast to 3D approaches. We show that DPNN is more effective in comparison to existing state-of-the-art and plausible baselines.Comment: 8 pages, 3 figures, conference, MICCAI DLMIA, 201

Semantic Perceptual Image Compression using Deep Convolution Networks

It has long been considered a significant problem to improve the visual quality of lossy image and video compression. Recent advances in computing power together with the availability of large training data sets has increased interest in the application of deep learning cnns to address image recognition and image processing tasks. Here, we present a powerful cnn tailored to the specific task of semantic image understanding to achieve higher visual quality in lossy compression. A modest increase in complexity is incorporated to the encoder which allows a standard, off-the-shelf jpeg decoder to be used. While jpeg encoding may be optimized for generic images, the process is ultimately unaware of the specific content of the image to be compressed. Our technique makes jpeg content-aware by designing and training a model to identify multiple semantic regions in a given image. Unlike object detection techniques, our model does not require labeling of object positions and is able to identify objects in a single pass. We present a new cnn architecture directed specifically to image compression, which generates a map that highlights semantically-salient regions so that they can be encoded at higher quality as compared to background regions. By adding a complete set of features for every class, and then taking a threshold over the sum of all feature activations, we generate a map that highlights semantically-salient regions so that they can be encoded at a better quality compared to background regions. Experiments are presented on the Kodak PhotoCD dataset and the MIT Saliency Benchmark dataset, in which our algorithm achieves higher visual quality for the same compressed size.Comment: Accepted to Data Compression Conference, 11 pages, 5 figure

Generative Compression

Traditional image and video compression algorithms rely on hand-crafted encoder/decoder pairs (codecs) that lack adaptability and are agnostic to the data being compressed. Here we describe the concept of generative compression, the compression of data using generative models, and suggest that it is a direction worth pursuing to produce more accurate and visually pleasing reconstructions at much deeper compression levels for both image and video data. We also demonstrate that generative compression is orders-of-magnitude more resilient to bit error rates (e.g. from noisy wireless channels) than traditional variable-length coding schemes

Linear and Geometric Mixtures - Analysis

Linear and geometric mixtures are two methods to combine arbitrary models in data compression. Geometric mixtures generalize the empirically well-performing PAQ7 mixture. Both mixture schemes rely on weight vectors, which heavily determine their performance. Typically weight vectors are identified via Online Gradient Descent. In this work we show that one can obtain strong code length bounds for such a weight estimation scheme. These bounds hold for arbitrary input sequences. For this purpose we introduce the class of nice mixtures and analyze how Online Gradient Descent with a fixed step size combined with a nice mixture performs. These results translate to linear and geometric mixtures, which are nice, as we show. The results hold for PAQ7 mixtures as well, thus we provide the first theoretical analysis of PAQ7.Comment: Data Compression Conference (DCC) 201