4,328 research outputs found
Hypothesis Testing For Network Data in Functional Neuroimaging
In recent years, it has become common practice in neuroscience to use
networks to summarize relational information in a set of measurements,
typically assumed to be reflective of either functional or structural
relationships between regions of interest in the brain. One of the most basic
tasks of interest in the analysis of such data is the testing of hypotheses, in
answer to questions such as "Is there a difference between the networks of
these two groups of subjects?" In the classical setting, where the unit of
interest is a scalar or a vector, such questions are answered through the use
of familiar two-sample testing strategies. Networks, however, are not Euclidean
objects, and hence classical methods do not directly apply. We address this
challenge by drawing on concepts and techniques from geometry, and
high-dimensional statistical inference. Our work is based on a precise
geometric characterization of the space of graph Laplacian matrices and a
nonparametric notion of averaging due to Fr\'echet. We motivate and illustrate
our resulting methodologies for testing in the context of networks derived from
functional neuroimaging data on human subjects from the 1000 Functional
Connectomes Project. In particular, we show that this global test is more
statistical powerful, than a mass-univariate approach. In addition, we have
also provided a method for visualizing the individual contribution of each edge
to the overall test statistic.Comment: 34 pages. 5 figure
Classification and Geometry of General Perceptual Manifolds
Perceptual manifolds arise when a neural population responds to an ensemble
of sensory signals associated with different physical features (e.g.,
orientation, pose, scale, location, and intensity) of the same perceptual
object. Object recognition and discrimination requires classifying the
manifolds in a manner that is insensitive to variability within a manifold. How
neuronal systems give rise to invariant object classification and recognition
is a fundamental problem in brain theory as well as in machine learning. Here
we study the ability of a readout network to classify objects from their
perceptual manifold representations. We develop a statistical mechanical theory
for the linear classification of manifolds with arbitrary geometry revealing a
remarkable relation to the mathematics of conic decomposition. Novel
geometrical measures of manifold radius and manifold dimension are introduced
which can explain the classification capacity for manifolds of various
geometries. The general theory is demonstrated on a number of representative
manifolds, including L2 ellipsoids prototypical of strictly convex manifolds,
L1 balls representing polytopes consisting of finite sample points, and
orientation manifolds which arise from neurons tuned to respond to a continuous
angle variable, such as object orientation. The effects of label sparsity on
the classification capacity of manifolds are elucidated, revealing a scaling
relation between label sparsity and manifold radius. Theoretical predictions
are corroborated by numerical simulations using recently developed algorithms
to compute maximum margin solutions for manifold dichotomies. Our theory and
its extensions provide a powerful and rich framework for applying statistical
mechanics of linear classification to data arising from neuronal responses to
object stimuli, as well as to artificial deep networks trained for object
recognition tasks.Comment: 24 pages, 12 figures, Supplementary Material
Geometric deep learning: going beyond Euclidean data
Many scientific fields study data with an underlying structure that is a
non-Euclidean space. Some examples include social networks in computational
social sciences, sensor networks in communications, functional networks in
brain imaging, regulatory networks in genetics, and meshed surfaces in computer
graphics. In many applications, such geometric data are large and complex (in
the case of social networks, on the scale of billions), and are natural targets
for machine learning techniques. In particular, we would like to use deep
neural networks, which have recently proven to be powerful tools for a broad
range of problems from computer vision, natural language processing, and audio
analysis. However, these tools have been most successful on data with an
underlying Euclidean or grid-like structure, and in cases where the invariances
of these structures are built into networks used to model them. Geometric deep
learning is an umbrella term for emerging techniques attempting to generalize
(structured) deep neural models to non-Euclidean domains such as graphs and
manifolds. The purpose of this paper is to overview different examples of
geometric deep learning problems and present available solutions, key
difficulties, applications, and future research directions in this nascent
field
Unified Heat Kernel Regression for Diffusion, Kernel Smoothing and Wavelets on Manifolds and Its Application to Mandible Growth Modeling in CT Images
We present a novel kernel regression framework for smoothing scalar surface
data using the Laplace-Beltrami eigenfunctions. Starting with the heat kernel
constructed from the eigenfunctions, we formulate a new bivariate kernel
regression framework as a weighted eigenfunction expansion with the heat kernel
as the weights. The new kernel regression is mathematically equivalent to
isotropic heat diffusion, kernel smoothing and recently popular diffusion
wavelets. Unlike many previous partial differential equation based approaches
involving diffusion, our approach represents the solution of diffusion
analytically, reducing numerical inaccuracy and slow convergence. The numerical
implementation is validated on a unit sphere using spherical harmonics. As an
illustration, we have applied the method in characterizing the localized growth
pattern of mandible surfaces obtained in CT images from subjects between ages 0
and 20 years by regressing the length of displacement vectors with respect to
the template surface.Comment: Accepted in Medical Image Analysi
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