Explainable Classification of Brain Networks via Contrast Subgraphs

Mining human-brain networks to discover patterns that can be used to discriminate between healthy individuals and patients affected by some neurological disorder, is a fundamental task in neuroscience. Learning simple and interpretable models is as important as mere classification accuracy. In this paper we introduce a novel approach for classifying brain networks based on extracting contrast subgraphs, i.e., a set of vertices whose induced subgraphs are dense in one class of graphs and sparse in the other. We formally define the problem and present an algorithmic solution for extracting contrast subgraphs. We then apply our method to a brain-network dataset consisting of children affected by Autism Spectrum Disorder and children Typically Developed. Our analysis confirms the interestingness of the discovered patterns, which match background knowledge in the neuroscience literature. Further analysis on other classification tasks confirm the simplicity, soundness, and high explainability of our proposal, which also exhibits superior classification accuracy, to more complex state-of-the-art methods.Comment: To be published at KDD 202

Mining Density Contrast Subgraphs

Dense subgraph discovery is a key primitive in many graph mining applications, such as detecting communities in social networks and mining gene correlation from biological data. Most studies on dense subgraph mining only deal with one graph. However, in many applications, we have more than one graph describing relations among a same group of entities. In this paper, given two graphs sharing the same set of vertices, we investigate the problem of detecting subgraphs that contrast the most with respect to density. We call such subgraphs Density Contrast Subgraphs, or DCS in short. Two widely used graph density measures, average degree and graph affinity, are considered. For both density measures, mining DCS is equivalent to mining the densest subgraph from a "difference" graph, which may have both positive and negative edge weights. Due to the existence of negative edge weights, existing dense subgraph detection algorithms cannot identify the subgraph we need. We prove the computational hardness of mining DCS under the two graph density measures and develop efficient algorithms to find DCS. We also conduct extensive experiments on several real-world datasets to evaluate our algorithms. The experimental results show that our algorithms are both effective and efficient.Comment: Full version of an ICDE'18 pape