A novel method for determining the Femoral-Tibial Angle of Knee Osteoarthritis on X-ray radiographs:data from the Osteoarthritis Initiative

Femoral-tibial alignment is a prominent risk factor for Knee Osteoarthritis (KOA) incidence and progression. One way of assessing alignment is by determining the Femoral-Tibial Angle (FTA). Several studies have investigated FTA determination; however, methods of assessment of FTA still present challenges. This paper introduces a new method for semi-automatic measurement of FTA as part of KOA research. Our novel approach combines preprocessing of X-ray images and the use of Active Shape Model (ASM) as the femoral and tibial segmentation method, followed by a thinning process. The result of the thinning process is used to predict FTA automatically by measuring the angle between the intersection of the two vectors of branching points on the femoral and tibial areas. The proposed method is trained on 10 x-ray images and tested on 50 different x-ray images of the Osteoarthritis Initiative (OAI) dataset. The outcomes of this approach were compared with manually obtained FTA measurements from the OAI dataset as the ground truth. Based on experiments, the difference in measurement results between the FTA of the OAI and the FTA obtained using our method is quite small, i.e., below 0.81 for the right FTA and below 0.77 for the left FTA with minimal average errors. This result indicates that this method is clinically suitable for semi-automatic measurement of the FTA. Computer science; Medical imaging; Knee osteoarthritis; X-ray; Femoral-tibial angle; Active shape mode

Rapid prototyping of image contrast enhancement hardware accelerator on FPGAs using high-level synthesis tools

© The PublisherRapid prototyping tools have become essential in the race to market. In this work, we have explored employing rapid prototyping approach to develop an intellectual property core for real-time contrast enhancement which is a commonly employed image processing task. Specifically, the task involves real-time contrast enhancement of video frames, which is used to repair washed out (overexposed) or darkened (underexposed) appearance. Such scenario is frequently encountered in video footage captured underwater. Since the imaging conditions are not known a priori, the lower and upper limits of the dynamic range of acquired luminance values need to be adaptively determined and mapped to the full range permitted by the allocated bitwidth so that the processed image has a high-contrast appearance. This paper describes a hardware implementation of this operation using contrast stretching algorithm with the help of Simulink high-level synthesis tool using rapid prototyping paradigm. The developed model can be directly used as a drop-in module in larger computer vision systems to enhance Simulink computer vision toolbox capabilities, which does not support this operation for direct FPGA implementation yet. The synthesized core consumes less than 1% of total FPGA slice logic resources while dissipating only 7 mW dynamic power. To this end, look-up table has been employed to implement the division operator which otherwise requires exorbitantly large number of logic resources. Moreover, an online algorithm has been proposed which avoids multiple memory accesses. The hardware module has been tested in a real-time video processing scenario at 100 MHz clock rate and depicts functional accuracy at par with the software while consuming lower logic resources than competitive designs. These results demonstrate that the appropriate use of modern rapid prototyping tools can be highly effective in reducing the development time without compromising the functional accuracy and resource utilization.The authors acknowledge the fund from the British Counci