Automatic 3DS Conversion of Historical Aerial Photographs

In this paper we present a method for the generation of 3D stereo (3DS) pairs from sequences of historical aerial photographs. The goal of our work is to provide a stereoscopic display when the existing exposures are in a monocular sequence. Each input image is processed using its neighbours and a synthetic image is rendered, which, together with the original one, form a stereo pair. Promising results on real images taken from a historical photo archive are shown, that corroborate the viability of generating 3DS data from monocular footage

Holoscopic 3D imaging and display technology: Camera/ processing/ display

This thesis was submitted for the award of Doctor of Philosophy and was awarded by Brunel University LondonHoloscopic 3D imaging “Integral imaging” was first proposed by Lippmann in 1908. It has become an attractive technique for creating full colour 3D scene that exists in space. It promotes a single camera aperture for recording spatial information of a real scene and it uses a regularly spaced microlens arrays to simulate the principle of Fly’s eye technique, which creates physical duplicates of light field “true 3D-imaging technique”. While stereoscopic and multiview 3D imaging systems which simulate human eye technique are widely available in the commercial market, holoscopic 3D imaging technology is still in the research phase. The aim of this research is to investigate spatial resolution of holoscopic 3D imaging and display technology, which includes holoscopic 3D camera, processing and display. Smart microlens array architecture is proposed that doubles spatial resolution of holoscopic 3D camera horizontally by trading horizontal and vertical resolutions. In particular, it overcomes unbalanced pixel aspect ratio of unidirectional holoscopic 3D images. In addition, omnidirectional holoscopic 3D computer graphics rendering techniques are proposed that simplify the rendering complexity and facilitate holoscopic 3D content generation. Holoscopic 3D image stitching algorithm is proposed that widens overall viewing angle of holoscopic 3D camera aperture and pre-processing of holoscopic 3D image filters are proposed for spatial data alignment and 3D image data processing. In addition, Dynamic hyperlinker tool is developed that offers interactive holoscopic 3D video content search-ability and browse-ability. Novel pixel mapping techniques are proposed that improves spatial resolution and visual definition in space. For instance, 4D-DSPM enhances 3D pixels per inch from 44 3D-PPIs to 176 3D-PPIs horizontally and achieves spatial resolution of 1365 × 384 3D-Pixels whereas the traditional spatial resolution is 341 × 1536 3D-Pixels. In addition distributed pixel mapping is proposed that improves quality of holoscopic 3D scene in space by creating RGB-colour channel elemental images

Real-Time Trigger and online Data Reduction based on Machine Learning Methods for Particle Detector Technology

Moderne Teilchenbeschleuniger-Experimente generieren während zur Laufzeit immense Datenmengen. Die gesamte erzeugte Datenmenge abzuspeichern, überschreitet hierbei schnell das verfügbare Budget für die Infrastruktur zur Datenauslese. Dieses Problem wird üblicherweise durch eine Kombination von Trigger- und Datenreduktionsmechanismen adressiert. Beide Mechanismen werden dabei so nahe wie möglich an den Detektoren platziert um die gewünschte Reduktion der ausgehenden Datenraten so frühzeitig wie möglich zu ermöglichen. In solchen Systeme traditionell genutzte Verfahren haben währenddessen ihre Mühe damit eine effiziente Reduktion in modernen Experimenten zu erzielen. Die Gründe dafür liegen zum Teil in den komplexen Verteilungen der auftretenden Untergrund Ereignissen. Diese Situation wird bei der Entwicklung der Detektorauslese durch die vorab unbekannten Eigenschaften des Beschleunigers und Detektors während des Betriebs unter hoher Luminosität verstärkt. Aus diesem Grund wird eine robuste und flexible algorithmische Alternative benötigt, welche von Verfahren aus dem maschinellen Lernen bereitgestellt werden kann. Da solche Trigger- und Datenreduktion-Systeme unter erschwerten Bedingungen wie engem Latenz-Budget, einer großen Anzahl zu nutzender Verbindungen zur Datenübertragung und allgemeinen Echtzeitanforderungen betrieben werden müssen, werden oft FPGAs als technologische Basis für die Umsetzung genutzt. Innerhalb dieser Arbeit wurden mehrere Ansätze auf Basis von FPGAs entwickelt und umgesetzt, welche die vorherrschenden Problemstellungen für das Belle II Experiment adressieren. Diese Ansätze werden über diese Arbeit hinweg vorgestellt und diskutiert werden

Modeling metabolism of Mycobacterium tuberculosis

Approximately one-fourth of the Mycobacterium tuberculosis (Mtb) genome contains genes that encode enzymes directly involved in its metabolism. These enzymes represent potential drug targets that can be systematically probed with constraint based (CB) models through the prediction of genes essential (or the combination thereof) for the pathogen to grow. However, gene essentiality depends on the growth conditions and, so far, no in vitro model precisely mimics the host at the different stages of mycobacterial infection, limiting model predictions. A first step in creating such a model is a thoroughly curated and extended genome-scale CB metabolic model of Mtb metabolism. The history of genome-scale CB models of Mtb metabolism up to model sMtb are discussed and sMtb is quantitatively validated using 13C measurements. The human pathogen Mtb has the capacity to escape eradication by professional phagocytes. During infection, Mtb resists the harsh environment of phagosomes and actively manipulates macrophages and dendritic cells to ensure prolonged intracellular survival. In contrast to many other intracellular pathogens, it has remained difficult to capture the transcriptome of mycobacteria during infection due to an unfavorable host-to-pathogen ratio. The human macrophage-like cell line THP-1 was infected with the attenuated Mtb surrogate Mycobacterium bovis Bacillus Calmette–Guérin (M. bovis BCG). Mycobacterial RNA was up to 1000-fold underrepresented in total RNA preparations of infected host cells. By combining microbial enrichment with specific ribosomal RNA depletion the transcriptional responses of host and pathogen during infection were simultaneously analyzed using dual RNA sequencing. Mycobacterial pathways for cholesterol degradation and iron acquisition are upregulated during infection. In addition, genes involved in the methylcitrate cycle, aspartate metabolism and recycling of mycolic acids are induced. In response to M. bovis BCG infection, host cells upregulate de novo cholesterol biosynthesis presumably to compensate for the loss of this metabolite by bacterial catabolism. By systematically probing the metabolic network underpinning sMtb, the reactions that are essential for Mtb are identified. A majority of these reactions are catalyzed by enzymes and thus represent candidate drug targets to fight an Mtb infection. Modeling the behavior of the bacteria during infection requires knowledge of the so-called biomass reaction that represents bacterial biomass composition. This composition varies in different environments or bacterial growth phases. Accurate modeling of all fluxes through metabolism under a given condition at a moment in time, the so called metabolic state, requires a precise description of the biomass reaction for the described condition. The transcript abundance data obtained by dual RNA sequencing was used to develop a straightforward and systematic method to obtain a condition-specific biomass reaction for Mtb during in vitro growth and during infection of its host. The method described herein is virtually free of any pre-set assumptions on uptake rates of nutrients, making it suitable for exploring environments with limited accessibility. The condition-specific biomass reaction represents the 'metabolic objective' of Mtb in a given environment (in-host growth and growth on defined medium) at a specific time point, and as such allows modeling the bacterial metabolic state in these environments. Five different biomass reactions were used predict nutrient uptake rates and gene essentiality. Predictions were subsequently compared to available experimental data. Nutrient uptake can accurately be predicted, but accurate gene essentiality predictions remain difficult to obtain. By combining sMtb and a model of human metabolism, model sMtb-RECON was developed and used to predict the metabolic state of Mtb during infection of the host. Amino acids are predicted to be used for energy production as well as biomass formation. Subsequently the effect of increasing dosages of drugs, targeting metabolism, on the metabolic state of the pathogen was assessed and resulting metabolic adaptations and flux rerouting through various pathways is predicted. In particular, the TCA cycle becomes more important upon drug application, as well as alanine, aspartate, glutamate, proline, arginine and porphyrin metabolism, while glycine, serine and threonine metabolism become less important for survival. Notably, an effect of eight out of eleven metabolically active drugs could be recreated and two major profiles of the metabolic state were predicted. The profiles of the metabolic states of Mtb affected by the drugs BTZ043, cycloserine and its derivative terizidone, ethambutol, ethionamide, propionamide, and isoniazid were very similar, while TMC207 is predicted to have quite a different effect on metabolism as it inhibits ATP synthase and therefore indirectly interferes with a multitude of metabolic pathways.</p

Analysis of Visualisation and Interaction Tools Authors

This document provides an in-depth analysis of visualization and interaction tools employed in the context of Virtual Museum. This analysis is required to identify and design the tools and the different components that will be part of the Common Implementation Framework (CIF). The CIF will be the base of the web-based services and tools to support the development of Virtual Museums with particular attention to online Virtual Museum.The main goal is to provide to the stakeholders and developers an useful platform to support and help them in the development of their projects, despite the nature of the project itself. The design of the Common Implementation Framework (CIF) is based on an analysis of the typical workflow ofthe V-MUST partners and their perceived limitations of current technologies. This document is based also on the results of the V-MUST technical questionnaire (presented in the Deliverable 4.1). Based on these two source of information, we have selected some important tools (mainly visualization tools) and services and we elaborate some first guidelines and ideas for the design and development of the CIF, that shall provide a technological foundation for the V-MUST Platform, together with the V-MUST repository/repositories and the additional services defined in the WP4. Two state of the art reports, one about user interface design and another one about visualization technologies have been also provided in this document

Diphthong Synthesis using the Three-Dimensional Dynamic Digital Waveguide Mesh

The human voice is a complex and nuanced instrument, and despite many years of research, no system is yet capable of producing natural-sounding synthetic speech. This affects intelligibility for some groups of listeners, in applications such as automated announcements and screen readers. Furthermore, those who require a computer to speak - due to surgery or a degenerative disease - are limited to unnatural-sounding voices that lack expressive control and may not match the user's gender, age or accent. It is evident that natural, personalised and controllable synthetic speech systems are required. A three-dimensional digital waveguide model of the vocal tract, based on magnetic resonance imaging data, is proposed here in order to address these issues. The model uses a heterogeneous digital waveguide mesh method to represent the vocal tract airway and surrounding tissues, facilitating dynamic movement and hence speech output. The accuracy of the method is validated by comparison with audio recordings of natural speech, and perceptual tests are performed which confirm that the proposed model sounds significantly more natural than simpler digital waveguide mesh vocal tract models. Control of such a model is also considered, and a proof-of-concept study is presented using a deep neural network to control the parameters of a two-dimensional vocal tract model, resulting in intelligible speech output and paving the way for extension of the control system to the proposed three-dimensional vocal tract model. Future improvements to the system are also discussed in detail. This project considers both the naturalness and control issues associated with synthetic speech and therefore represents a significant step towards improved synthetic speech for use across society

Nanopartículas sintetizadas en microemulsión agua/AOT/isooctano y su aplicación en hidrotratamientos en fase acuosa

Tesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Química Física Aplicada. Fecha de lectura: 04-07-2017Esta tesis tiene embargado el acceso al texto completo hasta el 04-01-201