276 research outputs found

    Bacteria classification with an electronic nose employing artificial neural networks

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    This PhD thesis describes research for a medical application of electronic nose technology. There is a need at present for early detection of bacterial infection in order to improve treatment. At present, the clinical methods used to detect and classify bacteria types (usually using samples of infected matter taken from patients) can take up to two or three days. Many experienced medical staff, who treat bacterial infections, are able to recognise some types of bacteria from their odours. Identification of pathogens (i.e. bacteria responsible for disease) from their odours using an electronic nose could provide a rapid measurement and therefore early treatment. This research project used existing sensor technology in the form of an electronic nose in conjunction with data pre-processing and classification methods to classify up to four bacteria types from their odours. Research was performed mostly in the area of signal conditioning, data pre-processing and classification. A major area of interest was the use of artificial neural networks classifiers. There were three main objectives. First, to classify successfully a small range of bacteria types. Second, to identify issues relating to bacteria odour that affect the ability of an artificially intelligent system to classify bacteria from odour alone. And third, to establish optimal signal conditioning, data pre-processing and classification methods. The Electronic Nose consisted of a gas sensor array with temperature and humidity sensors, signal conditioning circuits, and gas flow apparatus. The bacteria odour was analysed using an automated sampling system, which used computer software to direct gas flow through one of several vessels (which were used to contain the odour samples, into the Electronic Nose. The electrical resistance of the odour sensors were monitored and output as electronic signals to a computer. The purpose of the automated sampling system was to improve repeatability and reduce human error. Further improvement of the Electronic Nose were implemented as a temperature control system which controlled the ambient gas temperature, and a new gas sensor chamber which incorporated improved gas flow. The odour data were collected and stored as numerical values within data files in the computer system. Once the data were stored in a non-volatile manner various classification experiments were performed. Comparisons were made and conclusions were drawn from the performance of various data pre-processing and classification methods. Classification methods employed included artificial neural networks, discriminant function analysis and multi-variate linear regression. For classifying one from four types, the best accuracy achieved was 92.78%. This was achieved using a growth phase compensated multiple layer perceptron. For identifying a single bacteria type from a mixture of two different types, the best accuracy was 96.30%. This was achieved using a standard multiple layer perceptron. Classification of bacteria odours is a typical `real world' application of the kind that electronic noses will have to be applied to if this technology is to be successful. The methods and principles researched here are one step towards the goal of introducing artificially intelligent sensor systems into everyday use. The results are promising and showed that it is feasible to used Electronic Nose technology in this application and that with further development useful products could be developed. The conclusion from this thesis is that an electronic nose can detect and classify different types of bacteria

    Measuring the impact of COVID-19 on hospital care pathways

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    Care pathways in hospitals around the world reported significant disruption during the recent COVID-19 pandemic but measuring the actual impact is more problematic. Process mining can be useful for hospital management to measure the conformance of real-life care to what might be considered normal operations. In this study, we aim to demonstrate that process mining can be used to investigate process changes associated with complex disruptive events. We studied perturbations to accident and emergency (A &E) and maternity pathways in a UK public hospital during the COVID-19 pandemic. Co-incidentally the hospital had implemented a Command Centre approach for patient-flow management affording an opportunity to study both the planned improvement and the disruption due to the pandemic. Our study proposes and demonstrates a method for measuring and investigating the impact of such planned and unplanned disruptions affecting hospital care pathways. We found that during the pandemic, both A &E and maternity pathways had measurable reductions in the mean length of stay and a measurable drop in the percentage of pathways conforming to normative models. There were no distinctive patterns of monthly mean values of length of stay nor conformance throughout the phases of the installation of the hospital’s new Command Centre approach. Due to a deficit in the available A &E data, the findings for A &E pathways could not be interpreted

    Research Paper: Process Mining and Synthetic Health Data: Reflections and Lessons Learnt

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    Analysing the treatment pathways in real-world health data can provide valuable insight for clinicians and decision-makers. However, the procedures for acquiring real-world data for research can be restrictive, time-consuming and risks disclosing identifiable information. Synthetic data might enable representative analysis without direct access to sensitive data. In the first part of our paper, we propose an approach for grading synthetic data for process analysis based on its fidelity to relationships found in real-world data. In the second part, we apply our grading approach by assessing cancer patient pathways in a synthetic healthcare dataset (The Simulacrum provided by the English National Cancer Registration and Analysis Service) using process mining. Visualisations of the patient pathways within the synthetic data appear plausible, showing relationships between events confirmed in the underlying non-synthetic data. Data quality issues are also present within the synthetic data which reflect real-world problems and artefacts from the synthetic dataset’s creation. Process mining of synthetic data in healthcare is an emerging field with novel challenges. We conclude that researchers should be aware of the risks when extrapolating results produced from research on synthetic data to real-world scenarios and assess findings with analysts who are able to view the underlying data

    Process Mining for Smart Product Design

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    Process Mining Handbook

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    This is an open access book. This book comprises all the single courses given as part of the First Summer School on Process Mining, PMSS 2022, which was held in Aachen, Germany, during July 4-8, 2022. This volume contains 17 chapters organized into the following topical sections: Introduction; process discovery; conformance checking; data preprocessing; process enhancement and monitoring; assorted process mining topics; industrial perspective and applications; and closing

    Combining SOA and BPM Technologies for Cross-System Process Automation

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    This paper summarizes the results of an industry case study that introduced a cross-system business process automation solution based on a combination of SOA and BPM standard technologies (i.e., BPMN, BPEL, WSDL). Besides discussing major weaknesses of the existing, custom-built, solution and comparing them against experiences with the developed prototype, the paper presents a course of action for transforming the current solution into the proposed solution. This includes a general approach, consisting of four distinct steps, as well as specific action items that are to be performed for every step. The discussion also covers language and tool support and challenges arising from the transformation

    Products and Services

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    Today’s global economy offers more opportunities, but is also more complex and competitive than ever before. This fact leads to a wide range of research activity in different fields of interest, especially in the so-called high-tech sectors. This book is a result of widespread research and development activity from many researchers worldwide, covering the aspects of development activities in general, as well as various aspects of the practical application of knowledge
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