Normal brain-skull development with hybrid deformable VR models simulation

This paper describes a simulation framework for a clinical application involving skull-brain co-development in infants, leading to a platform for craniosynostosis modeling. Craniosynostosis occurs when one or more sutures are fused early in life, resulting in an abnormal skull shape. Surgery is required to reopen the suture and reduce intracranial pressure, but is difficult without any predictive model to assist surgical planning. We aim to study normal brain-skull growth by computer simulation, which requires a head model and appropriate mathematical methods for brain and skull growth respectively. On the basis of our previous model, we further specified suture model into fibrous and cartilaginous sutures and develop algorithm for skull extension. We evaluate the resulting simulation by comparison with datasets of cases and normal growth

Evaluation System for Craniosynostosis Surgeries with Computer Simulation and Statistical Modelling

Craniosynostosis is a pathology in infants when one or more sutures prematurely closed, leading to abnormal skull shape. It has been classified according to the specific suture that has been closed, each of which has a typical skull shape. Surgery is the common treatment to correct the deformed skull shape and to reduce the excessive intracranial pressure. Since every case is unique, the cranial facial teams have difficulties to select an optimum solution for a specific patient from multiple options. In addition, there is not an appropriate quantified measurement existed currently to help cranial facial team to quantitatively evaluate their surgeries. We aimed to develop a head model of a craniosynostosis patient, which allows neurosurgeons to perform any potential surgeries on it so as to simulate the postoperative head development. Therefore, neurosurgeons could foresee the surgical results and is able to select the optimal one. In this thesis, we have developed a normal head model, and built mathematical models for possible dynamic behaviors. We also modified this model by closing one or two sutures to simulate common types of craniosynostosis. The abnormal simulation results showed a qualitative match with real cases and the normal simulation indicated a higher growth rate of cranial index than clinical data. We believed that this discrepancy caused by the rigidity of our skull plates, which will be adapted to deformable object in the future. In order to help neurosurgeons to better evaluate a surgery, we hope to develop an algorithm to quantify the level of deformity of a skull. We have designed a set of work flow and targeted curvatures as the key role. A training data was carefully selected to search for an optimal system to characterize different shapes. A set of test data was used to validate our algorithm to assess the performance of the optimal system. With a stable evaluating system, we can evaluate a surgery by comparing the preoperative and postoperative skulls from the patient. An effective surgery can be considered if the postoperative skull shifted toward normal shape from preoperative shape