An investigation of genetic polymorphism in association with Type 2 diabetes and metabolic syndrome.

Type 2 diabetes and metabolic syndrome are the metabolic disorders which constitute a major public health problem in both developed and developing countries. Various studies have suggested the genetic susceptibility to the disorders. The main aim of the thesis was to investigate the putative association of single nucleotide polymorphisms with Type 2 diabetes (T2D), metabolic syndrome (MetS) and the major components of metabolic syndrome. This study used metaanalysis, polymerase chain reaction (PCR) based restriction fragment length polymorphism (RFLP) and Sanger sequencing methods to analyse the results. The single nucleotide polymorphism rs57829442 of peroxisome proliferatoractivated receptorγ coactivator1 (PPARGC1A) gene and its relation to risk of type 2 diabetes has been studied in the United Kingdom population. A metaanalysis of genetic variant rs8192678 (Gly482Ser) of peroxisome proliferatoractivated receptorγ coactivator1 (PPARGC1A) gene and its association with the components of metabolic syndrome has been studied. An association of the genetic variants rs8192678 (Gly482Ser) of the PPARGC1A gene, rs7903146 of Transcription Factor 7 Like 2 (TCF7L2) gene, rs9939609 of Fat mass and obesityassociated (FTO) gene and rs1801282 (Pro12Ala) of peroxisome proliferatoractivated receptor gamma (PPARG) gene with the metabolic syndrome and its components has been studied in the Nepalese population. The results showed that variant rs57829442 of PPARGC1A is not associated with T2D in the United Kingdom population. Further investigation with increased sample size is warranted. In the metaanalysis, the variant rs8192678 (Gly482Ser) of PPARGC1A gene was found to be significantly associated with body mass index (BMI) in Asian populations under dominant genetic model, total cholesterol (TC) in nonAsian population under recessive genetic model and with fasting plasma glucose (FPG) under a recessive model in overall and nonAsian populations. No significant association of the variants rs8192678 (Gly482Ser), rs7903146, rs9939609 and rs1801282 (Pro12 Ala) was found associated with MetS under dominant, recessive, codominant and additive models in the Nepalese population. However, the genotypes (AG and AA) of rs8192678 (Gly482Ser) had a statistically significant protective effect on systolic blood pressure. The genotypes with the risk allele of rs9930609 of FTO gene was significantly associated with weight, waist circumference and diastolic blood pressure under dominant genetic model and with BMI under both dominant and recessive genetic models in the Nepalese population. To the best of our knowledge, this is the first study to report the findings in the Nepalese population

Leadership Influences of the Veteran Alpha Female Leader

In recent years, more women have entered positions of leadership, and their alpha personalities have compelled them to strive for higher positions of authority. With this influx, it has become necessary to better understand the influences of this type of female leader and to expand narrow conceptualizations. Previous studies examined alpha female leaders of high school and college-age, but studies have yet to explore this type of leader beyond college. This phenomenological study sought to examine the influence of the minority identity, life experience, and leadership duration on veteran alpha female leaders. It was grounded in social-role and ethnic-identity theory. During semistructured interviews, 12 veteran alpha female leaders of various ethnicities explained their experiences. The data were analyzed using the Colaizzi method; 409 significant statements were extracted and then clustered into 8 themes. The findings indicated that although alpha qualities can emerge early, most attributes take time to develop. Seeking opportunities and ongoing mentoring influenced leader experiences and contributed to success and leadership duration. Through exploration of the minority identity status (e.g. gender, ethnicity, culture, etc.) increased motivational influences were found as a direct result of the minority identity, these findings indicated that leaders of color were particularly susceptible to more than one motivational influence. Increased understanding of veteran alpha women could help to improve leadership practices and enhance working relationships, which better support the personalities of this valuable but sometimes challenging leadership type. The general acceptance of alpha women in leadership roles promotes positive social change by helping to facilitate growth in female leadership representation

Diabetaction, programme d'exercice pour personnes diabétiques de type 2 ou à risque : effets sur la pratique d'activités physiques, la condition physique, la qualité de vie et différents paramètres de santé

Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal

健康之友； [Friend of Health: brand new issue next year. Take care of your health. ]

50 Nonasian; The origin of the image is Domestic. Watermark Unknown

《天鹅湖》；《胡桃夹子》；《睡美人》； [Russian Ballet. NovoSibirsk State Academic Opera and Ballet Theatre from Russia will bring Beijing a week of performances of Tchaikovsky's best-known three ballet works, ""Swan Lake,"" ""Sleeping Beauty"" and ""Nutcracker."" Live music by Russian National]

This image contains 21 people; 21 female(s); 21 Nonasian; The origin of the image is Foreign. Watermark Unknown