Graphene-based field-effect transistor biosensors for the rapid detection and analysis of viruses: A perspective in view of COVID-19

Current situation of COVID-19 demands a rapid, reliable, cost-effective, facile detection strategy to break the transmission chain and biosensor has emerged as a feasible solution for this purpose. Introduction of nanomaterials has undoubtedly improved the performance of biosensor and the addition of graphene enhanced the sensing ability to a peerless level. Amongst different graphene-based biosensing schemes, graphene field-effect transistor marked its unique presence owing to its ability of ultrasensitive and low-noise detection thereby facilitating instantaneous measurements even in the presence of small amounts of analytes. Recently, graphene field-effect transistor type biosensor is even successfully employed in rapid detection of SARS-CoV-2 and this triggers the interest of the scientific community in reviewing the current developments in graphene field-effect transistor. Subsequently, in this article, the recent progress in graphene field-effect transistor type biosensors for the detection of the virus is reviewed and challenges along with their strengths are discussed.Comment: COVID-19, Biosensor, Graphene Field-effect transistor, Virus detectio

Ground-based gravitational-wave detection: now and future

In the past three years, the first generation of large gravitational-wave interferometers has begun operation near their design sensitivities, taking up the mantle from the bar detectors that pioneered the search for the first direct detection of gravitational waves. Even as the current ground-based interferometers were reaching their design sensitivities, plans were being laid for the future. Advances in technology and lessons learned from the first generation devices have pointed the way to an order of magnitude improvement in sensitivity, as well as expanded frequency ranges and the capability to tailor the sensitivity band to address particular astrophysical sources. Advanced cryogenic acoustic detectors, the successors to the current bar detectors, are being researched and may play a role in the future, particularly at the higher frequencies. One of the most important trends is the growing international cooperation aimed at building a truly global network. In this paper, I survey the state of the various detectors as of mid-2007, and outline the prospects for the future

Quantum metrology and its application in biology

Quantum metrology provides a route to overcome practical limits in sensing devices. It holds particular relevance to biology, where sensitivity and resolution constraints restrict applications both in fundamental biophysics and in medicine. Here, we review quantum metrology from this biological context, focusing on optical techniques due to their particular relevance for biological imaging, sensing, and stimulation. Our understanding of quantum mechanics has already enabled important applications in biology, including positron emission tomography (PET) with entangled photons, magnetic resonance imaging (MRI) using nuclear magnetic resonance, and bio-magnetic imaging with superconducting quantum interference devices (SQUIDs). In quantum metrology an even greater range of applications arise from the ability to not just understand, but to engineer, coherence and correlations at the quantum level. In the past few years, quite dramatic progress has been seen in applying these ideas into biological systems. Capabilities that have been demonstrated include enhanced sensitivity and resolution, immunity to imaging artifacts and technical noise, and characterization of the biological response to light at the single-photon level. New quantum measurement techniques offer even greater promise, raising the prospect for improved multi-photon microscopy and magnetic imaging, among many other possible applications. Realization of this potential will require cross-disciplinary input from researchers in both biology and quantum physics. In this review we seek to communicate the developments of quantum metrology in a way that is accessible to biologists and biophysicists, while providing sufficient detail to allow the interested reader to obtain a solid understanding of the field. We further seek to introduce quantum physicists to some of the central challenges of optical measurements in biological science.Comment: Submitted review article, comments and suggestions welcom

Inter-satellite Quantum Key Distribution at Terahertz Frequencies

Terahertz (THz) communication is a topic of much research in the context of high-capacity next-generation wireless networks. Quantum communication is also a topic of intensive research, most recently in the context of space-based deployments. In this work we explore the use of THz frequencies as a means to achieve quantum communication within a constellation of micro-satellites in Low-Earth-Orbit (LEO). Quantum communication between the micro-satellite constellation and high-altitude terrestrial stations is also investigated. Our work demonstrates that THz quantum entanglement distribution and THz quantum key distribution are viable deployment options in the micro-satellite context. We discuss how such deployment opens up the possibility for simpler integration of global quantum and wireless networks. The possibility of using THz frequencies for quantum-radar applications in the context of LEO deployments is briefly discussed.Comment: 7 pages, 6 figure