Generalized Factorization in Non-leptonic Two-Body B-Decays: a Critical Look

We reanalyze critically the generalized factorization hypothesis in non-leptonic two-body B-decays discussed recently by several authors. In particular we address the determination of the factorization scale $\mu_f$ and of the non-perturbative parameters $\xi^{NF}_1 (m_b)$ and $\xi^{NF}_2 (m_b)$ which are supposed to measure non-factorizable contributions to hadronic matrix elements with $\xi^{NF}_i (\mu_f) = 0$. We emphasize that both $\mu_f$ and $\xi^{NF}_i (m_b)$ are renormalization scheme dependent and we demonstrate analytically and numerically that for any chosen scale \mu_f=\ord(m_b) it is possible to find a renormalization scheme for which $\xi^{NF}_1 (\mu_f) = \xi^{NF}_2 (\mu_f)=0$. The existing data indicate that such "factorization schemes" differ from the commonly used schemes NDR and HV. Similarly we point out that the recent extractions of the effective number of colours $N^{eff}$ from two-body non-leptonic B-decays while $\mu$ and renormalization scheme independent suffer from gauge dependences and infrared dependences.Comment: 20 pages, 2 figure

Evidence linking exposure of fish primary macrophages to antibiotics activates the NF-kB pathway.

Low doses of antibiotics are ubiquitous in the marine environment and may exert negative effects on non-target aquatic organisms. Using primary macrophages of common carp, we investigated the mechanisms of action following exposure to several common antibiotics; cefotaxime, enrofloxacin, tetracycline, sulfamonomethoxine, and their mixtures, and explored the immunomodulatory effects associated with the nuclear factor-κB (NF-κB) signaling pathway. A KEGG pathway analysis was conducted using the sixty-six differentially expressed genes found in all treatments, and showed that exposure to 100 μg/L of antibiotics could affect regulation of the NF-κB signaling pathway, suggesting that activation of NF-κB is a common response in all four classes of antibiotics. In addition, the four antibiotics induced nf-κb and NF-κB-associated cytokines expression, as verified by qPCR, however, these induction responses by four antibiotics were minor when compared to the same concentration of LPS treatment (100 μg/L). Antagonists of NF-κB blocked many of the immune effects of the antibiotics, providing evidence that NF-κB pathways mediate the actions of all four antibiotics. Moreover, exposure to environmentally relevant, low levels (0.01-100 μg/L) of antibiotics induced a NF-κB-mediated immune response, including endogenous generation of ROS, activity of antioxidant enzymes, as well as expression of cytokine and apoptosis. Moreover, exposure to mixtures of antibiotics presented greater effects on most tested immunological parameters than exposure to a single antibiotic, suggesting additive effects from multiple antibiotics in the environment. This study demonstrates that exposure of fish primary macrophages to low doses of antibiotics activates the NF-kB pathway

Interpolating between low and high energy QCD via a 5D Yang-Mills model

We describe the Goldstone bosons of massless QCD together with an infinite number of spin-1 mesons. The field content of the model is SU(Nf)xSU(Nf) Yang-Mills in a compact extra-dimension. Electroweak interactions reside on one brane. Breaking of chiral symmetry occurs due to the boundary conditions on the other brane, away from our world, and is therefore spontaneous. Our implementation of the holographic recipe maintains chiral symmetry explicit throughout. For intermediate energies, we extract resonance couplings. These satisfy sum rules due to the 5D nature of the model. These sum rules imply, when taking the high energy limit, that perturbative QCD constraints are satisfied. We also illustrate how the 5D model implies a definite prescription for handling infinite sums over 4D resonances. Taking the low energy limit, we recover the chiral expansion and the corresponding non-local order parameters. All local order parameters are introduced separately.Comment: Corresponds to published version, with some typos correcte

D3-D7 Quark-Gluon Plasmas at Finite Baryon Density

We present the string dual to SU(Nc) N=4 SYM, coupled to Nf massless fundamental flavors, at finite temperature and baryon density. The solution is determined by two dimensionless parameters, both depending on the 't Hooft coupling $\lambda_h$ at the scale set by the temperature T: $\epsilon_h\sim\lambda_h Nf/Nc$, weighting the backreaction of the flavor fields and $\tilde\delta\sim\lambda_h^{-1/2}nb/(Nf T^3)$, where $nb$ is the baryon density. For small values of these two parameters the solution is given analytically up to second order. We study the thermodynamics of the system in the canonical and grand-canonical ensembles. We then analyze the energy loss of partons moving through the plasma, computing the jet quenching parameter and studying its dependence on the baryon density. Finally, we analyze certain "optical" properties of the plasma. The whole setup is generalized to non abelian strongly coupled plasmas engineered on D3-D7 systems with D3-branes placed at the tip of a generic singular Calabi-Yau cone. In all the cases, fundamental matter fields are introduced by means of homogeneously smeared D7-branes and the flavor symmetry group is thus a product of abelian factors.Comment: 27 pages; v2: 29 pages, 1 (new) figure, new section 4.4 on optical properties, references, comments added; v3: eq. (3.19), comments and a reference adde

Insights into the behaviour of systems biology models from dynamic sensitivity and identifiability analysis: a case study of an NF-kB signaling pathway

Mathematical modelling offers a variety of useful techniques to help in understanding the intrinsic behaviour of complex signal transduction networks. From the system engineering point of view, the dynamics of metabolic and signal transduction models can always be described by nonlinear ordinary differential equations (ODEs) following mass balance principles. Based on the state-space formulation, many methods from the area of automatic control can conveniently be applied to the modelling, analysis and design of cell networks. In the present study, dynamic sensitivity analysis is performed on a model of the IB-NF-B signal pathway system. Univariate analysis of the Euclidean-form overall sensitivities shows that only 8 out of the 64 parameters in the model have major influence on the nuclear NF-B oscillations. The sensitivity matrix is then used to address correlation analysis, identifiability assessment and measurement set selection within the framework of least squares estimation and multivariate analysis. It is shown that certain pairs of parameters are exactly or highly correlated to each other in terms of their effects on the measured variables. The experimental design strategy provides guidance on which proteins should best be considered for measurement such that the unknown parameters can be estimated with the best statistical precision. The whole analysis scheme we describe provides efficient parameter estimation techniques for complex cell networks

Solitons in Supersymmetric Gauge Theories: Moduli Matrix Approach

We review our recent works on solitons in U(Nc) gauge theories with Nf (>Nc) Higgs fields in the fundamental representation, which possess eight supercharges. The moduli matrix is proposed as a crucial tool to exhaust all BPS solutions, and to characterize all possible moduli parameters. Since vacua are in the Higgs phase, we find domain walls (kinks) and vortices as the only elementary solitons. Stable monopoles and instantons can exist as composite solitons with vortices attached. Webs of walls are also found as another composite soliton. The moduli space of all these elementary as well as composite solitons are found in terms of the moduli matrix. The total moduli space of walls is given by the complex Grassmann manifold SU(Nf)/[SU(Nc)x SU(Nf-Nc) x U(1)] and is decomposed into various topological sectors corresponding to boundary conditions specified by particular vacua. We found charges characterizing composite solitons contribute negatively (either positively or negatively) in Abelian (non-Abelian) gauge theories. Effective Lagrangians are constructed on walls and vortices in a compact form. The power of the moduli matrix is illustrated by an interaction rule of monopoles, vortices, and walls, which is difficult to obtain in other methods. More thorough description of the moduli matrix approach can be found in our review article (hep-th/0602170).Comment: 14 pages, 9 figures, proceedings of CAQC