ANALISIS PENGARUH RETURN ON ASSETS (ROA), RETURN ON EQUITY (ROE) DAN NET PROFIT MARGIN (NPM) TERHADAP RETURN SAHAM PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA

Title "The Analysis Return on assets (ROA), return on equity (ROE), net profit margin (NPM) of the return on the stock of manufacturing companies listed in Indonesia Stock Exchange." This research aims to influence the performance tester manufacturing company (ROA, ROE, and NPM) of the shares and return of these three variables (ROA, ROE, and NPM) where the most significant return to shareholders registered at the Indonesian Stock Exchange. In this research, data analysis technique that is used is to perform calculations find ROA, ROE, NPM, stock return from year 2005,2006,2007, perform statistical testing, test the assumption of classical regression analysis and berganda. Research results indicate that simultaneously calculated F = 0.609 less than the F table = 3.80 means ROA, ROE, and NPM does not affect the stock return. And that the partial calculating ROA T = 0.899 T is less than the table means = 1.77 ROA does not affect the stock return. ROE calculated T = -0.437 is less than the table T = 1.77 does not mean ROE barpangaruh return to shareholders. NPM calculated T = -1.123 is less than Q = 1.77 means that the table NPM does not affect the stock return. This condition indicates that the ROA, ROE and NPM has contributed to a low return on shar

Expression and Functional Studies on the Noncoding RNA, PRINS.

PRINS, a noncoding RNA identified earlier by our research group, contributes to psoriasis susceptibility and cellular stress response. We have now studied the cellular and histological distribution of PRINS by using in situ hybridization and demonstrated variable expressions in different human tissues and a consistent staining pattern in epidermal keratinocytes and in vitro cultured keratinocytes. To identify the cellular function(s) of PRINS, we searched for a direct interacting partner(s) of this stress-induced molecule. In HaCaT and NHEK cell lysates, the protein proved to be nucleophosmin (NPM) protein as a potential physical interactor with PRINS. Immunohistochemical experiments revealed an elevated expression of NPM in the dividing cells of the basal layers of psoriatic involved skin samples as compared with healthy and psoriatic uninvolved samples. Others have previously shown that NPM is a ubiquitously expressed nucleolar phosphoprotein which shuttles to the nucleoplasm after UV-B irradiation in fibroblasts and cancer cells. We detected a similar translocation of NPM in UV-B-irradiated cultured keratinocytes. The gene-specific silencing of PRINS resulted in the retention of NPM in the nucleolus of UV-B-irradiated keratinocytes; suggesting that PRINS may play a role in the NPM-mediated cellular stress response in the skin

Governance, rational choice and new public management (npm): a general view (and some critics)

This article aims to study the New Public Management (NPM), one of the main trends associated to neoliberalism. It studies governance to show its general, wider and abstract scope. It also focuses on the Rational Choice as an important theory about governance, a basis for NPM. And it observes the neoliberal foundations of NPM, showing critical aspects of its real practice. Methodology: hypothetical deductive method of research, with a qualitative and critical approach and bibliographic-documental research technique. As results of this research, we can conclude that: i) the ideological usage of NPM has been expressed in a culture of minimal state and government - but in practice, such culture, when embossing implemented reforms, seldom reverted the role of the state, destroyed social safety nets, and placed the tax burden on the working majority rather than on the wealthy elite; ii) advocates for NPM have Western-shaped minds, generally making erroneous assumptions about institutions and cultures, which may be present in Anglo-American countries, but not in other culturally different ones; iii) in practice, NPM reforms were imposed to low-income countries by donor institutions to adjust their states for good governance - but those reforms did not solve problems with inefficiency and corruption. This work is original and valuable because it shows that even when public policies highlight the importance of less state intervention, solid norms and institutions are always necessary, and because it helps demystifying discourses that simply put that less state/more market politics can be valuable everywhere

New public management and employee share ownership plan in Fiji’s public sector

This article provides insights into the implementation of new public management (NPM) practices in Fiji Telecom and whether the use of the employee share ownership scheme was helpful in the organisational change process. The NPM practices were influenced by the World Bank and International Monetary Fund who were the lenders to Fiji government. The adoption of NPM practices was part of a political, economic and public sector reforms introduced after 1989. The paper discusses the background and obstacles of the reform and how the employee share ownership scheme practice at a privatised Telecom Company assists employees to assimilate commercial business norms. The authors finally make recommendations for policy-makers in Fiji and other developing nations

Devolved school-based financial management in New Zealand : observations on the conformity patterns of school organisations to change

This paper examines the intent and consequences of ‘new’ financial management (the ‘New Public Financial Management’) (NPFM) procedures invoked to facilitate a macro-micro interface within the context of the significant administrative reform of the New Zealand (NZ) state education system. The 1989 administrative reform of the NZ education system was predicated on a particular view of public sector management, which was characterised by the umbrella heading of ‘New Public Management’ (NPM). It was claimed that NPFM provided a link between the sets of values highlighted through the NPM reform process and the internal workings of various public sector organisations. The study provides case studies of the organisational financial management practices of four schools, some ten years after the reform. The observed practices are analysed and interpreted within a theoretical framework comprising two competing theories of change – NPM which provides the ‘normative’ intent for public sector organisational change, and institutional theory that offers an explanation of the ‘operational’ consequences of public sector organisational (i.e. schools) response to change. The findings suggest that accounting and management technologies have served a useful, political purpose, although not in the way espoused by NPM proponents

AKT regulates NPM dependent ARF localization and p53mut stability in tumors

Nucleophosmin (NPM) is known to regulate ARF subcellular localization and MDM2 activity in response to oncogenic stress, though the precise mechanism has remained elusive. Here we describe how NPM and ARF associate in the nucleoplasm to form a MDM2 inhibitory complex. We find that oligomerization of NPM drives nucleolar accumulation of ARF. Moreover, the formation of NPM and ARF oligomers antagonizes MDM2 association with the inhibitory complex, leading to activation of MDM2 E3-ligase activity and targeting of p53. We find that AKT phosphorylation of NPM-Ser48 prevents oligomerization that results in nucleoplasmic localization of ARF, constitutive MDM2 inhibition and stabilization of p53. We also show that ARF promotes p53 mutant stability in tumors and suppresses p73 mediated p21 expression and senescence. We demonstrate that AKT and PI3K inhibitors may be effective in treatment of therapeutically resistant tumors with elevated AKT and carrying gain of function mutations in p53. Our results show that the clinical candidate AKT inhibitor MK-2206 promotes ARF nucleolar localization, reduced p53(mut) stability and increased sensitivity to ionizing radiation in a xenograft model of pancreatic cancer. Analysis of human tumors indicates that phospho-S48-NPM may be a useful biomarker for monitoring AKT activity and in vivo efficacy of AKT inhibitor treatment. Critically, we propose that combination therapy involving PI3K-AKT inhibitors would benefit from a patient stratification rationale based on ARF and p53(mut) status

Auditing culture : the subsidised cultural sector in the New Public Management

This article explores the effects of the spread of the principles and practices of the New Public Management (NPM) on the subsidised cultural sector and on cultural policy making in Britain. In particular, changes in the style of public administration that can be ascribed to the NPM will be shown to provide a useful framework to make sense of what has been felt as an “instrumental turn” in British policies for culture between the early 1980s and the present day. The current New Labour Government, as well as the arm's length bodies that distribute public funds for the cultural sector in Britain, are showing an increasing tendency to justify public spending on the arts on the basis of instrumental notions of the arts and culture. In the context of what have been defined as “instrumental cultural policies”, the arts are subsidised in so far as they represent a means to an end rather than an end in itself. In this perspective, the emphasis placed on the potential of the arts to help tackle social exclusion and the role of the cultural sector in place‐marketing and local economic development are typical examples of current trends in British cultural policy making. The central argument purported by this article is that this instrumental emphasis in British cultural policy is closely linked to the changes in the style of public administration that have given rise to the NPM. These new developments have indeed put the publicly funded cultural sector under increasing pressure. In particular, it will be shown how the new stress on the measurement of the arts' impacts in clear and quantifiable ways – which characterises today's “audit society” – has proved a tough challenge for the sector and one that has not been successfully met. The article will conclude by critically considering how the spread of the NPM has affected processes of policy making for the cultural sector, and the damaging effects that such developments may ultimately have on the arts themselves

PENGARUH KINERJA KEUANGAN DAN INFLASI TERHADAP HARGA SAHAM PADA PERUSAHAN YANG TERMASUK DALAM INDEKS LQ45 PERIODE 2003-2007

The purposes of study are to know the financial activity which consists of EPS, ROE, NPM, DER, and inflation has significance influent toward stock holder cost, and to know the variables of EPS, Roe, NPM, DER, and the variables which has dominant influent toward stock holder cost. The data anlysis were used in this research was double linier aggression by using F and T test. \ud The result of F test could be known in variable EPS, ROE, NPM, DER, and simulation inflation which had significance influent toward stock holder cost in a company which included LQ45 indeks 2003-2007. based on the research, it can be concluded that first hypothesis which was done in this research was acceptable. Based on the result of each \ud regression coefficient of the variables could be explained that the variable of EPS was 108,036; ROE was 127, 613; NPM was 102, 651; DER was -1,252; and inflation was -0,006. \ud It could be conluded that Roe had the most important significance influent toward the stock holder costs in company which included LQ45 indeks 2003-2007