بررسی سطح ليپيدها و ليپوپروتئين‌های سرم خون در بيماران مبتلا به ديابت مليتوس تيپ 2 با گرفتگی عروق کرونر STUDY OF SERUM LIPID AND LIPOPROTEIN LEVELS IN PATIENTS WITH CORONARY ARTERY DISEASE AND TYPE 2 DIABETES MELLITUS

گرفتگی عروق کرونر قلب ( CAD ) يکی از علل مرگ و مير در بيماران ديابتی غيروابسته به انسولين ( NIDDM ) می‌باشد. يکی از عوامل خطرزا در ابتلا به CAD ، غيرطبيعی بودن ليپيدها است. با توجه به شيوع بالای NIDDM و CAD در مردم کشورمان، در اين مطالعه، سطح ليپيدها و ليپوپروتئين‌ها در سرم خون 2 گروه از بيماران (گروه + /NIDDM + CAD و گروه - /NIDDM + CAD ) اندازه‌گيری و با يکديگر مقايسه گرديد. هر کدام از گروه‌های + /NIDDM + CAD و - /NIDDM + CAD شامل 50 بيمار بودند که گرفتگی عروق کرونر در آنها توسط آنژيوگرافی مورد تاييد قرار گرفته بود. همچنين يک گروه کنترل که شامل 30 نفر فرد سالم بود، در نظر گرفته شد که اين افراد مبتلا به CAD و ديابت نبودند(- /NIDDM - CAD ). غلظت کلسترول و تری‌گليسريد و HDL-c سرم خون، با استفاده از روش آنزيمی و استفاده از اتو آناليزر اندازه‌گيری گرديد. سطح سرمی ليپيدها و ليپوپروتئين‌های سرم خون، در گروه + /NIDDM + CAD در مقايسه با گروه - /NIDDM + CAD تفاوت معنی‌دار آماری نداشــت. سطــح HDL-c ســرم در گروه + /NIDDM + CAD درمقايسه با افراد سالم پايينتر بود(01/0 P< ). افزايش معنی‌داری در نسبتهای TC/HDL-c و LDL-c/HDL-c در گروه + /NIDDM + CAD و گروه - /NIDDM + CAD در مقايسه با افراد سالم وجود داشت. در اين مطالعه مشاهده شد که سطح سرمی ليپيدها و ليپوپروتئين‌ها در بيماران ديابتی مبتلا به CAD در مقايسه با بيماران غيرديابتی مبتلا به CAD ، تفاوت معنی‌دار آماری ندارد، بنابراين بنظر می‌رسد که غيرطبيعی بودن ليپيدها در بيماران ديابتی با ابتلا به CAD ارتباطی ندارد اما سطح سرمی HDL-c و نسبتهای TC/HDL-c و LDL-c/HDL-c در بيماران ديابتی و غيرديابتی مبتلا به CAD ، در مقايسه با افراد سالم تفاوت معنی‌داری را نشان داد. با توجه به نتايج اين مطالعه بايد گفت که پارامترهای ذکر شده، در پيگيری پيشرفت CAD در بيماران ديابتی اهميت دارد

The Effect of Phyllanthus Amarus Aqueous Extract on Blood Glucose in Non-Insulin Dependent Diabetic Patients

The glycaemic response to 124.5 ± 9.3 (mean ± SD) g of pancakes was monitored in 21 non-insulin dependent diabetic (NIDDM) patients while on oral hypoglycaemics, after a one week washout period and after a one week twice daily treatment with 100 ml of an aqueous extract from 12.5 g of powdered aerial parts of Phyllanthus amarus. After the one week washout period, fasting blood glucose (FBG) and postprandial blood glucose increased significantly compared to when on oral hypoglycaemics (P ≤ 0.05). After one week herbal treatment no hypoglycaemic activity was observed. Both FBG and postprandial blood glucose remained very similar to that recorded after the washout period (P > 0.05). Both liver and renal functions based on alanine transaminase (ALAT) and serum creatinine, respectively, were not significantly affected by the use of the extract. Although lymphocyte and monocyte levels were significantly decreased (P ≤ 0.05) and granulocyte level was significantly increased after treatment (P ≤ 0.05) overall total white blood cell (WBC) count and haemoglobin (Hb) were not significantly affected by the one week herbal treatment. We conclude that one week treatment with the aqueous extract of Phyllanthus amarus was incapable of lowering both FBG and postprandial blood glucose in untreated NIDDM patients

Diabetes status and post-load plasma glucose concentration in relation to site-specific cancer mortality: findings from the original Whitehall study

ObjectiveWhile several studies have reported on the relation of diabetes status with pancreatic cancer risk, the predictive value of this disorder for other malignancies is unclear. Methods: The Whitehall study, a 25year follow-up for mortality experience of 18,006 men with data on post-challenge blood glucose and self-reported diabetes, allowed us to address these issues. Results: There were 2158 cancer deaths at follow-up. Of the 15 cancer outcomes, diabetes status was positively associated with mortality from carcinoma of the pancreas and liver, while the relationship with lung cancer was inverse, after controlling for a range of potential covariates and mediators which included obesity and socioeconomic position. After excluding deaths occurring in the first 10years of follow-up to examine the effect of reverse causality, the magnitude of the relationships for carcinoma of the pancreas and lung was little altered, while for liver cancer it was markedly attenuated. Conclusions: In the present study, diabetes status was related to pancreatic, liver, and lung cancer risk. Cohorts with serially collected data on blood glucose and covariates are required to further examine this area

What's in a Name? Classification of Diabetes Mellitus in Veterinary Medicine and Why It Matters

Diabetes Mellitus (DM) is a syndrome caused by various etiologies. The clinical manifestations of DM are not indicative of the cause of the disease, but might be indicative of the stage and severity of the disease process. Accurately diagnosing and classifying diabetic dogs and cats by the underlying disease process is essential for current and future studies on early detection, prevention, and treatment of underlying disease. Here, we review the current etiology‐based classification of DM and definitions of DM types in human medicine and discuss key points on the pathogenesis of each DM type and prediabetes. We then review current evidence for application of this etiology‐based classification scheme in dogs and cats. In dogs, we emphasize the lack of consistent evidence for autoimmune DM (Type 1) and the possible importance of other DM types such as DM associated with exocrine pancreatic disease. While most dogs are first examined because of DM in an insulin‐dependent state, early and accurate diagnosis of the underlying disease process could change the long‐term outcome and allow some degree of insulin independence. In cats, we review the appropriateness of using the umbrella term of Type 2 DM and differentiating it from DM secondary to other endocrine disease like hypersomatotropism. This differentiation could have crucial implications on treatment and prognosis. We also discuss the challenges in defining and diagnosing prediabetes in cats

Birth outcome in relation to licorice consumption during pregnancy.

A role for glucocorticoids is suspected in the etiology of low birth weight. The authors tested whether maternal consumption of glycyrrhizin (an inhibitor of cortisol metabolism) in licorice affects birth weight in humans. A sample of 1,049 Finnish women and their healthy singleton infants was studied in 1998. Glycyrrhizin intake was calculated from detailed questionnaires on licorice consumption. Glycyrrhizin exposure was grouped into three levels: low ( or =500 mg/week; n = 110). Birth weight and gestational age (from ultrasound measurements) were obtained from hospital records. Babies with heavy exposure to glycyrrhizin were not significantly lighter at birth, but they were significantly more likely to be born earlier: The odds ratio for being born before 38 weeks' gestation was 2.5 (95% confidence interval: 1.1, 5.5; p = 0.03). Although the effect of heavy glycyrrhizin intake on mean duration of gestation was small (2.52 days) when expressed as an effect on the mean, this shift to the left of the distribution of duration of gestation was sufficient to double the risk of being born before 38 weeks. The association remained in multivariate analyses. In conclusion, heavy glycyrrhizin exposure during pregnancy did not significantly affect birth weight or maternal blood pressure, but it was significantly associated with lower gestational age

The study of diabetes mellitus in Gorgan, Iran

[No abstract available