Effective Temperature Of Uranus

NASA NGR 09-015-047, NGR 22-007-270, NGR 44-012-152Astronom

Nonperiodic Optical Flickering In Hz Herculis

NASA NGR 44-012-209NSF GP-25901, GP-41796Astronom

E-Process - Its Components And Their Neutron Excesses

NSF GP-18335, GP-32051NASA NGR-44-006-159Astronom

On the Velocity of Light Signals in the Deep Underwater Neutrino Experiments

During the last few years deep underwater neutrino telescopes of a new generation with dimensions close to 100 m or more were taken into operation. For the correct track reconstruction and for the interpretation of light pulses from calibration lasers one has to use the group velocity for light signals. The difference between group velocity leads to an additional delay of about 10 ns for a distance of 100 m between light source and photjmultiplier. From the time of the appearance of the first projects of deep underwater neutrino telescopes in the middle of 70th this fact was never mentioned in the literature.Comment: 4 pages, 2 figure

Measurements of group velocity of light in the lake Baikal water

The results of direct measurements of group velocity of light in the lake Baikal water at the depth of 1100 m are presented. The lake Baikal water dispersion has been measured at three wavelengths: 370 nm, 470 nm and 525 nm. The results are in a rather good agreement with theoretical predictions.Comment: 4 pages, 5 figures, talk presented at RICH2002, to be published in NIMA; misprints corrected in formula at page

In vivo imaging of Aminopeptidase N (CD13) receptors in experimental renal tumors using the novel radiotracer 68Ga-NOTA-c(NGR)

Purpose: Aminopeptidase N (APN/CD13) plays an important role in tumor neoangiogenic process and the development of metastases. Furthermore, it may serve as a potential target for cancer diagnosis and therapy. Previous studies have already shown that asparagine–glycine–arginine (NGR) peptides specifically bind to APN/CD13. The aim of the study was to synthesize and investigate the APN/CD13 specificity of a novel 68Ga-labeled NOTA-c(NGR) molecule in vivo using miniPET. Methods: c[KNGRE]-NH2 peptide was conjugated with p-SCN-Bn-NOTA and was labeled with Ga-68 (68Ga-NOTA-c(NGR)). Orthotopic and heterotopic transplanted mesoblastic nephroma (NeDe) bearing Fischer-344 rats were prepared, on which biodistribution studies and miniPET scans were performed for both 68Ga-NOTA-c(NGR) and amb3 integrin selective 68Ga-NODAGA-[c(RGD)]2 tracers. APN/CD13 receptor expression of NeDe tumors and metastases was analyzed by western blot. Results: 68Ga-NOTA-c(NGR) was produced with high specific activity (5.13–5.92 GBq/lmol) and with excellent radiochemical purity (95%<), at all cases. Biodistribution studies in normal rats showed that uptake of the 68Ga-NOTA-c(NGR) was significantly (p 6 0.05) lower in abdominal organs in comparison with 68Ga-NODAGA-[c(RGD)]2. Both radiotracers were mainly excreted from the kidney. In NeDe tumor bearing rats higher 68Ga-NOTA-c(NGR) accumulation was found in the tumors than that of the 68Ga-NODAGA-[ c(RGD)]2. Using orthotopic transplantation, metastases were developed which showed specific 68Ga-NOTA-c(NGR) uptake. Western blot analysis confirmed the presence of APN/CD13 expression in NeDe tumors and metastases