Automatic Classification of Human Epithelial Type 2 Cell Indirect Immunofluorescence Images using Cell Pyramid Matching

This paper describes a novel system for automatic classification of images obtained from Anti-Nuclear Antibody (ANA) pathology tests on Human Epithelial type 2 (HEp-2) cells using the Indirect Immunofluorescence (IIF) protocol. The IIF protocol on HEp-2 cells has been the hallmark method to identify the presence of ANAs, due to its high sensitivity and the large range of antigens that can be detected. However, it suffers from numerous shortcomings, such as being subjective as well as time and labour intensive. Computer Aided Diagnostic (CAD) systems have been developed to address these problems, which automatically classify a HEp-2 cell image into one of its known patterns (eg. speckled, homogeneous). Most of the existing CAD systems use handpicked features to represent a HEp-2 cell image, which may only work in limited scenarios. We propose a novel automatic cell image classification method termed Cell Pyramid Matching (CPM), which is comprised of regional histograms of visual words coupled with the Multiple Kernel Learning framework. We present a study of several variations of generating histograms and show the efficacy of the system on two publicly available datasets: the ICPR HEp-2 cell classification contest dataset and the SNPHEp-2 dataset.Comment: arXiv admin note: substantial text overlap with arXiv:1304.126

Hybrid multi-layer Deep CNN/Aggregator feature for image classification

Deep Convolutional Neural Networks (DCNN) have established a remarkable performance benchmark in the field of image classification, displacing classical approaches based on hand-tailored aggregations of local descriptors. Yet DCNNs impose high computational burdens both at training and at testing time, and training them requires collecting and annotating large amounts of training data. Supervised adaptation methods have been proposed in the literature that partially re-learn a transferred DCNN structure from a new target dataset. Yet these require expensive bounding-box annotations and are still computationally expensive to learn. In this paper, we address these shortcomings of DCNN adaptation schemes by proposing a hybrid approach that combines conventional, unsupervised aggregators such as Bag-of-Words (BoW), with the DCNN pipeline by treating the output of intermediate layers as densely extracted local descriptors. We test a variant of our approach that uses only intermediate DCNN layers on the standard PASCAL VOC 2007 dataset and show performance significantly higher than the standard BoW model and comparable to Fisher vector aggregation but with a feature that is 150 times smaller. A second variant of our approach that includes the fully connected DCNN layers significantly outperforms Fisher vector schemes and performs comparably to DCNN approaches adapted to Pascal VOC 2007, yet at only a small fraction of the training and testing cost.Comment: Accepted in ICASSP 2015 conference, 5 pages including reference, 4 figures and 2 table