Brain fame:From FPGA to heterogeneous acceleration of brain simulations

Among the various methods in neuroscience for understanding brain function, in-silico simulations have been gaining popularity. Advances in neuroscience and engineering led to the creation of mathematical models of networks that do not simply mimic biological behaviour in an abstract fashion but emulate its in significant detail, even to the level of its biophysical properties. Such an example is the Spiking Neural Network (SNN) that can model a variety of additional behavioural features, like encoding data and adapting according to a spike train`s amplitude, frequency and general precise pattern of arrival of spiking events on a neuron. As a result, SNNs have higher explanatory power than their predecessors, thus brain simulations based on SNNs become an attractive topic to explore. In-silico simulations of SNNs can have beneficial results not only for neuroscience research but breakthroughs can also potentially benefit medical, computing and A.I. research. SNNs, though, computationally depending workloads that traditional computing might not be able to cover. Thus, the use of High Performance Computing (HPC) platforms in this application domain becomes desirable. This dissertation explores the topic of HPC-based in-silico brain simulations. Initially, the effort focuses on custom hardware accelerators, due to their potential in providing real-time performance alongside support for large-scale non-real-time experiments and specifically Field Programmable Gate Arrays (FPGAs). The nature of FPGA-based accelerators provides specific benefits against other similar paradigms like Application Specific Integrated Circuit (ASIC) designs.Firstly, we explore the general characteristics of typical SNNs model types to identify their computational requirements in relation to their explanatory strength. We also identify major design characteristics in model development that can directly affect its performance and behaviour when ported to an HPC platform. Subsequently, a detailed literature review is made on FPGA-based SNN implementations. The HPC porting effort begins with the implementation of an extended-Hodgkin-Huxley model of the Inferior-olivary nucleus featuring advanced connectivity. The model is quite demanding and complex enough to act as a realistic benchmark for HPC implementations, while also being scientifically relevant in its own right. FPGA development shows promising performance results not only when doing custom designs but also using High-level synthesis (HLS) toolflows that significantly reduce development time. FPGAs have proven suitable for small-scale embedded-HPC uses as well. The various efforts, though, reveal a very specific weakness of FPGA development that has less to do with the silicon itself and more with its programming environment. The FPGA tools are very inaccessible to non-experts, thus any acceleration effort would require the engineer (and the FPGA development time) to be in the critical path of the research process. An important question to be answered is how the FPGA platform would compare to other popular software-based HPC solutions such as GPU- and CPU-based platforms. A detailed comparison of the best FPGA implementation with GPU and manycore-CPU ports of the same benchmark is conducted. The comparison and evaluation shows that, when it comes to real-time performance, FPGAs have a clear advantage. But for non-real-time, large scale simulations, there is no single platform that can optimally support the complete range of experiments that could be conducted with the inferior olive model. The comparison makes a clear case for BrainFrame, a platform that supports heterogeneous HPC substrates. This dissertation, thus, concludes with the proposal of the BrainFrame system. The proof-of-concept design supports standard and extended Hodgkin-Huxley models, , such as the original inferior-olive model. The system integrates a GPU-, CPU- and FPGA-based HPC back-end while also using a standard neuroscientific language front-end (PyNN) that can score best-in-class performance, alleviate some of the development hurdles and make it far more user-friendly for the typical model developer. Additionally, the multi-node potential of the platform is being explored. BrainFrame provides both a powerful heterogeneous platform for acceleration and also a front-end familiar to the neuroscientist