Bayesian Spatial Binary Regression for Label Fusion in Structural Neuroimaging

Many analyses of neuroimaging data involve studying one or more regions of interest (ROIs) in a brain image. In order to do so, each ROI must first be identified. Since every brain is unique, the location, size, and shape of each ROI varies across subjects. Thus, each ROI in a brain image must either be manually identified or (semi-) automatically delineated, a task referred to as segmentation. Automatic segmentation often involves mapping a previously manually segmented image to a new brain image and propagating the labels to obtain an estimate of where each ROI is located in the new image. A more recent approach to this problem is to propagate labels from multiple manually segmented atlases and combine the results using a process known as label fusion. To date, most label fusion algorithms either employ voting procedures or impose prior structure and subsequently find the maximum a posteriori estimator (i.e., the posterior mode) through optimization. We propose using a fully Bayesian spatial regression model for label fusion that facilitates direct incorporation of covariate information while making accessible the entire posterior distribution. We discuss the implementation of our model via Markov chain Monte Carlo and illustrate the procedure through both simulation and application to segmentation of the hippocampus, an anatomical structure known to be associated with Alzheimer's disease.Comment: 24 pages, 10 figure

Medical Image Segmentation Based on Multi-Modal Convolutional Neural Network: Study on Image Fusion Schemes

Image analysis using more than one modality (i.e. multi-modal) has been increasingly applied in the field of biomedical imaging. One of the challenges in performing the multimodal analysis is that there exist multiple schemes for fusing the information from different modalities, where such schemes are application-dependent and lack a unified framework to guide their designs. In this work we firstly propose a conceptual architecture for the image fusion schemes in supervised biomedical image analysis: fusing at the feature level, fusing at the classifier level, and fusing at the decision-making level. Further, motivated by the recent success in applying deep learning for natural image analysis, we implement the three image fusion schemes above based on the Convolutional Neural Network (CNN) with varied structures, and combined into a single framework. The proposed image segmentation framework is capable of analyzing the multi-modality images using different fusing schemes simultaneously. The framework is applied to detect the presence of soft tissue sarcoma from the combination of Magnetic Resonance Imaging (MRI), Computed Tomography (CT) and Positron Emission Tomography (PET) images. It is found from the results that while all the fusion schemes outperform the single-modality schemes, fusing at the feature level can generally achieve the best performance in terms of both accuracy and computational cost, but also suffers from the decreased robustness in the presence of large errors in any image modalities.Comment: Zhe Guo and Xiang Li contribute equally to this wor

Recent trends, technical concepts and components of computer-assisted orthopedic surgery systems: A comprehensive review

Computer-assisted orthopedic surgery (CAOS) systems have become one of the most important and challenging types of system in clinical orthopedics, as they enable precise treatment of musculoskeletal diseases, employing modern clinical navigation systems and surgical tools. This paper brings a comprehensive review of recent trends and possibilities of CAOS systems. There are three types of the surgical planning systems, including: systems based on the volumetric images (computer tomography (CT), magnetic resonance imaging (MRI) or ultrasound images), further systems utilize either 2D or 3D fluoroscopic images, and the last one utilizes the kinetic information about the joints and morphological information about the target bones. This complex review is focused on three fundamental aspects of CAOS systems: their essential components, types of CAOS systems, and mechanical tools used in CAOS systems. In this review, we also outline the possibilities for using ultrasound computer-assisted orthopedic surgery (UCAOS) systems as an alternative to conventionally used CAOS systems.Web of Science1923art. no. 519

Fast Predictive Multimodal Image Registration

We introduce a deep encoder-decoder architecture for image deformation prediction from multimodal images. Specifically, we design an image-patch-based deep network that jointly (i) learns an image similarity measure and (ii) the relationship between image patches and deformation parameters. While our method can be applied to general image registration formulations, we focus on the Large Deformation Diffeomorphic Metric Mapping (LDDMM) registration model. By predicting the initial momentum of the shooting formulation of LDDMM, we preserve its mathematical properties and drastically reduce the computation time, compared to optimization-based approaches. Furthermore, we create a Bayesian probabilistic version of the network that allows evaluation of registration uncertainty via sampling of the network at test time. We evaluate our method on a 3D brain MRI dataset using both T1- and T2-weighted images. Our experiments show that our method generates accurate predictions and that learning the similarity measure leads to more consistent registrations than relying on generic multimodal image similarity measures, such as mutual information. Our approach is an order of magnitude faster than optimization-based LDDMM.Comment: Accepted as a conference paper for ISBI 201