4,719 research outputs found

    Deep generative models for network data synthesis and monitoring

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    Measurement and monitoring are fundamental tasks in all networks, enabling the down-stream management and optimization of the network. Although networks inherently have abundant amounts of monitoring data, its access and effective measurement is another story. The challenges exist in many aspects. First, the inaccessibility of network monitoring data for external users, and it is hard to provide a high-fidelity dataset without leaking commercial sensitive information. Second, it could be very expensive to carry out effective data collection to cover a large-scale network system, considering the size of network growing, i.e., cell number of radio network and the number of flows in the Internet Service Provider (ISP) network. Third, it is difficult to ensure fidelity and efficiency simultaneously in network monitoring, as the available resources in the network element that can be applied to support the measurement function are too limited to implement sophisticated mechanisms. Finally, understanding and explaining the behavior of the network becomes challenging due to its size and complex structure. Various emerging optimization-based solutions (e.g., compressive sensing) or data-driven solutions (e.g. deep learning) have been proposed for the aforementioned challenges. However, the fidelity and efficiency of existing methods cannot yet meet the current network requirements. The contributions made in this thesis significantly advance the state of the art in the domain of network measurement and monitoring techniques. Overall, we leverage cutting-edge machine learning technology, deep generative modeling, throughout the entire thesis. First, we design and realize APPSHOT , an efficient city-scale network traffic sharing with a conditional generative model, which only requires open-source contextual data during inference (e.g., land use information and population distribution). Second, we develop an efficient drive testing system — GENDT, based on generative model, which combines graph neural networks, conditional generation, and quantified model uncertainty to enhance the efficiency of mobile drive testing. Third, we design and implement DISTILGAN, a high-fidelity, efficient, versatile, and real-time network telemetry system with latent GANs and spectral-temporal networks. Finally, we propose SPOTLIGHT , an accurate, explainable, and efficient anomaly detection system of the Open RAN (Radio Access Network) system. The lessons learned through this research are summarized, and interesting topics are discussed for future work in this domain. All proposed solutions have been evaluated with real-world datasets and applied to support different applications in real systems

    CANCER TREATMENT BY TARGETING HDAC4 TRANSLOCATION INDUCED BY MICROSECOND PULSED ELECTRIC FIELD EXPOSURE: MECHANISTIC INSIGHTS THROUGH KINASES AND PHOSPHATASES

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    Epigenetic modifications, arising from sub-cellular shifts in histone deacetylase (HDAC) activity and localization, present promising strategies for diverse cancer treatments. HDACs, enzymes responsible for post-translational histone modifications, induce these epigenetic changes by removing acetyl groups from ε-N-acetyl-lysine residues on histones, thereby suppressing gene transcription. Within the HDAC group, class IIa HDACs are notable for their responsiveness to extracellular signals, bridging the gap between external stimuli, plasma membrane, and genome through nuclear-cytoplasmic translocation. This localization offers two significant mechanisms for cancer treatment: nuclear accumulation of HDACs represses oncogenic transcription factors, such as myocyte-specific enhancer factor 2C (MEF2C), triggering various cell death pathways. Conversely, cytoplasmic HDAC accumulation acts similarly to HDAC inhibitors by silencing genes. My dissertation introduces an innovative approach for glioblastoma and breast cancer treatment by investigating the application of microsecond pulsed electric fields. It particularly focuses on HDAC4, a class IIa HDAC overexpressed in these cancers. Beyond demonstrating HDAC4 translocation, my research delves into the intricate roles of kinases and phosphatases, shedding light on the underlying factors governing HDAC4 translocation

    Machine Learning Approaches for the Prioritisation of Cardiovascular Disease Genes Following Genome- wide Association Study

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    Genome-wide association studies (GWAS) have revealed thousands of genetic loci, establishing itself as a valuable method for unravelling the complex biology of many diseases. As GWAS has grown in size and improved in study design to detect effects, identifying real causal signals, disentangling from other highly correlated markers associated by linkage disequilibrium (LD) remains challenging. This has severely limited GWAS findings and brought the method’s value into question. Although thousands of disease susceptibility loci have been reported, causal variants and genes at these loci remain elusive. Post-GWAS analysis aims to dissect the heterogeneity of variant and gene signals. In recent years, machine learning (ML) models have been developed for post-GWAS prioritisation. ML models have ranged from using logistic regression to more complex ensemble models such as random forests and gradient boosting, as well as deep learning models (i.e., neural networks). When combined with functional validation, these methods have shown important translational insights, providing a strong evidence-based approach to direct post-GWAS research. However, ML approaches are in their infancy across biological applications, and as they continue to evolve an evaluation of their robustness for GWAS prioritisation is needed. Here, I investigate the landscape of ML across: selected models, input features, bias risk, and output model performance, with a focus on building a prioritisation framework that is applied to blood pressure GWAS results and tested on re-application to blood lipid traits

    Beam scanning by liquid-crystal biasing in a modified SIW structure

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    A fixed-frequency beam-scanning 1D antenna based on Liquid Crystals (LCs) is designed for application in 2D scanning with lateral alignment. The 2D array environment imposes full decoupling of adjacent 1D antennas, which often conflicts with the LC requirement of DC biasing: the proposed design accommodates both. The LC medium is placed inside a Substrate Integrated Waveguide (SIW) modified to work as a Groove Gap Waveguide, with radiating slots etched on the upper broad wall, that radiates as a Leaky-Wave Antenna (LWA). This allows effective application of the DC bias voltage needed for tuning the LCs. At the same time, the RF field remains laterally confined, enabling the possibility to lay several antennas in parallel and achieve 2D beam scanning. The design is validated by simulation employing the actual properties of a commercial LC medium

    Is attention all you need in medical image analysis? A review

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    Medical imaging is a key component in clinical diagnosis, treatment planning and clinical trial design, accounting for almost 90% of all healthcare data. CNNs achieved performance gains in medical image analysis (MIA) over the last years. CNNs can efficiently model local pixel interactions and be trained on small-scale MI data. The main disadvantage of typical CNN models is that they ignore global pixel relationships within images, which limits their generalisation ability to understand out-of-distribution data with different 'global' information. The recent progress of Artificial Intelligence gave rise to Transformers, which can learn global relationships from data. However, full Transformer models need to be trained on large-scale data and involve tremendous computational complexity. Attention and Transformer compartments (Transf/Attention) which can well maintain properties for modelling global relationships, have been proposed as lighter alternatives of full Transformers. Recently, there is an increasing trend to co-pollinate complementary local-global properties from CNN and Transf/Attention architectures, which led to a new era of hybrid models. The past years have witnessed substantial growth in hybrid CNN-Transf/Attention models across diverse MIA problems. In this systematic review, we survey existing hybrid CNN-Transf/Attention models, review and unravel key architectural designs, analyse breakthroughs, and evaluate current and future opportunities as well as challenges. We also introduced a comprehensive analysis framework on generalisation opportunities of scientific and clinical impact, based on which new data-driven domain generalisation and adaptation methods can be stimulated

    Synthetic Aperture Radar (SAR) Meets Deep Learning

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    This reprint focuses on the application of the combination of synthetic aperture radars and depth learning technology. It aims to further promote the development of SAR image intelligent interpretation technology. A synthetic aperture radar (SAR) is an important active microwave imaging sensor, whose all-day and all-weather working capacity give it an important place in the remote sensing community. Since the United States launched the first SAR satellite, SAR has received much attention in the remote sensing community, e.g., in geological exploration, topographic mapping, disaster forecast, and traffic monitoring. It is valuable and meaningful, therefore, to study SAR-based remote sensing applications. In recent years, deep learning represented by convolution neural networks has promoted significant progress in the computer vision community, e.g., in face recognition, the driverless field and Internet of things (IoT). Deep learning can enable computational models with multiple processing layers to learn data representations with multiple-level abstractions. This can greatly improve the performance of various applications. This reprint provides a platform for researchers to handle the above significant challenges and present their innovative and cutting-edge research results when applying deep learning to SAR in various manuscript types, e.g., articles, letters, reviews and technical reports

    Cerebral Metamorphopsia: Perceived spatial distortion from lesions of the adult human central visual pathway

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    Metamorphopsia is the perceived visual illusion of spatial distortion. Cerebral causes of metamorphopsia are much less common than retinal or ocular causes. Cerebral metamorphopsia can be caused by lesions along the central visual pathway or as a manifestation of epileptogenic discharges. Geometric visual distortions may result from structural lesions of the central visual pathway after reorganisation of the retinotopic representation in the cortex. Very few experimental investigations have been performed regarding cerebral metamorphopsia as it is often viewed as a clinical curiousity and analysis of the perceived distortion is difficult due to its subjective nature. Investigations have been undertaken to understand cortical plasticity as an explanation for visual filling-in. There has been much interest in cortical reorganisation after injuries to the peripheral and central visual pathway. Behavioural experiments aimed at quantifying the possible visual spatial distortion surrounding homonymous paracentral scotomas may be able to demonstrate cortical reorganisation after brain-damage and provide clues regarding the neural processes of visual perception. The aims of the thesis are: 1. To identify which cases of metamorphopsia, both published and unpublished, might be a consequence of cortical spatial reorganisation of retinotopic projections. 2. To investigate perceptual spatial distortion surrounding homonymous paracentral scotomas in adults with isolated unilateral injuries of the striate cortex. A review of the literature describing cases of cerebral metamorphopsia was performed. Metamorphopsia caused by retinal or ocular pathology, psychiatric conditions, drugs or medications were excluded. A retrospective case series of eight patients with metamorphopsia from a cerebral cause was performed in two clinical neurology practices specialising in vision disorders. Two cases who suffered from paracentral homonymous scotomas due to isolated unilateral primary visual cortex (V1) lesions were identified from a Neuro-ophthalmology practice. Neuropsychophysical experiments to investigate visual spatial perception surrounding their scotomas were developed and tested using MATLAB and Psychtoolbox. The use of the term 'metamorphopsia' was only in reference to cases in which contours or lines were experienced as distorted. In the published literature, few cases of cerebral metamorphopsia have been identified as being potentially due to cortical reorganisation. The main result is a statistically significant visual spatial distortion in the visual field surrounding a paracentral homonymous scotoma when compared to a normal control. There is also significant distortion of perception in the subjects' "unaffected" visual hemifield. After lesions of V1, visual perceptual spatial distortions may occur in the visual field surrounding homonymous paracentral scotomas. The spatial distortion may also occur in the normal hemifield possibly due to long-range cortical connections crossing to the other hemisphere through the corpus callosum. A collaborative approach across disciplines within vision science is required to further investigate the mechanisms responsible for perceptual visual illusions. Behavioural testing in brain-damaged cases remains important in developing theories of normal visual processing. New neuroimaging and neuroscience techniques could then test these theories, furthering our understanding of visual perception. An understanding of normal visual perception could allow future modification of neuronal processes to harness cortical reorganisation and potentially restore functional vision in humans with lesions of the central visual pathway

    Adaptive vehicular networking with Deep Learning

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    Vehicular networks have been identified as a key enabler for future smart traffic applications aiming to improve on-road safety, increase road traffic efficiency, or provide advanced infotainment services to improve on-board comfort. However, the requirements of smart traffic applications also place demands on vehicular networks’ quality in terms of high data rates, low latency, and reliability, while simultaneously meeting the challenges of sustainability, green network development goals and energy efficiency. The advances in vehicular communication technologies combined with the peculiar characteristics of vehicular networks have brought challenges to traditional networking solutions designed around fixed parameters using complex mathematical optimisation. These challenges necessitate greater intelligence to be embedded in vehicular networks to realise adaptive network optimisation. As such, one promising solution is the use of Machine Learning (ML) algorithms to extract hidden patterns from collected data thus formulating adaptive network optimisation solutions with strong generalisation capabilities. In this thesis, an overview of the underlying technologies, applications, and characteristics of vehicular networks is presented, followed by the motivation of using ML and a general introduction of ML background. Additionally, a literature review of ML applications in vehicular networks is also presented drawing on the state-of-the-art of ML technology adoption. Three key challenging research topics have been identified centred around network optimisation and ML deployment aspects. The first research question and contribution focus on mobile Handover (HO) optimisation as vehicles pass between base stations; a Deep Reinforcement Learning (DRL) handover algorithm is proposed and evaluated against the currently deployed method. Simulation results suggest that the proposed algorithm can guarantee optimal HO decision in a realistic simulation setup. The second contribution explores distributed radio resource management optimisation. Two versions of a Federated Learning (FL) enhanced DRL algorithm are proposed and evaluated against other state-of-the-art ML solutions. Simulation results suggest that the proposed solution outperformed other benchmarks in overall resource utilisation efficiency, especially in generalisation scenarios. The third contribution looks at energy efficiency optimisation on the network side considering a backdrop of sustainability and green networking. A cell switching algorithm was developed based on a Graph Neural Network (GNN) model and the proposed energy efficiency scheme is able to achieve almost 95% of the metric normalised energy efficiency compared against the “ideal” optimal energy efficiency benchmark and is capable of being applied in many more general network configurations compared with the state-of-the-art ML benchmark

    Towards addressing training data scarcity challenge in emerging radio access networks: a survey and framework

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    The future of cellular networks is contingent on artificial intelligence (AI) based automation, particularly for radio access network (RAN) operation, optimization, and troubleshooting. To achieve such zero-touch automation, a myriad of AI-based solutions are being proposed in literature to leverage AI for modeling and optimizing network behavior to achieve the zero-touch automation goal. However, to work reliably, AI based automation, requires a deluge of training data. Consequently, the success of the proposed AI solutions is limited by a fundamental challenge faced by cellular network research community: scarcity of the training data. In this paper, we present an extensive review of classic and emerging techniques to address this challenge. We first identify the common data types in RAN and their known use-cases. We then present a taxonomized survey of techniques used in literature to address training data scarcity for various data types. This is followed by a framework to address the training data scarcity. The proposed framework builds on available information and combination of techniques including interpolation, domain-knowledge based, generative adversarial neural networks, transfer learning, autoencoders, fewshot learning, simulators and testbeds. Potential new techniques to enrich scarce data in cellular networks are also proposed, such as by matrix completion theory, and domain knowledge-based techniques leveraging different types of network geometries and network parameters. In addition, an overview of state-of-the art simulators and testbeds is also presented to make readers aware of current and emerging platforms to access real data in order to overcome the data scarcity challenge. The extensive survey of training data scarcity addressing techniques combined with proposed framework to select a suitable technique for given type of data, can assist researchers and network operators in choosing the appropriate methods to overcome the data scarcity challenge in leveraging AI to radio access network automation

    A robotic platform for precision agriculture and applications

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    Agricultural techniques have been improved over the centuries to match with the growing demand of an increase in global population. Farming applications are facing new challenges to satisfy global needs and the recent technology advancements in terms of robotic platforms can be exploited. As the orchard management is one of the most challenging applications because of its tree structure and the required interaction with the environment, it was targeted also by the University of Bologna research group to provide a customized solution addressing new concept for agricultural vehicles. The result of this research has blossomed into a new lightweight tracked vehicle capable of performing autonomous navigation both in the open-filed scenario and while travelling inside orchards for what has been called in-row navigation. The mechanical design concept, together with customized software implementation has been detailed to highlight the strengths of the platform and some further improvements envisioned to improve the overall performances. Static stability testing has proved that the vehicle can withstand steep slopes scenarios. Some improvements have also been investigated to refine the estimation of the slippage that occurs during turning maneuvers and that is typical of skid-steering tracked vehicles. The software architecture has been implemented using the Robot Operating System (ROS) framework, so to exploit community available packages related to common and basic functions, such as sensor interfaces, while allowing dedicated custom implementation of the navigation algorithm developed. Real-world testing inside the university’s experimental orchards have proven the robustness and stability of the solution with more than 800 hours of fieldwork. The vehicle has also enabled a wide range of autonomous tasks such as spraying, mowing, and on-the-field data collection capabilities. The latter can be exploited to automatically estimate relevant orchard properties such as fruit counting and sizing, canopy properties estimation, and autonomous fruit harvesting with post-harvesting estimations.Le tecniche agricole sono state migliorate nel corso dei secoli per soddisfare la crescente domanda di aumento della popolazione mondiale. I recenti progressi tecnologici in termini di piattaforme robotiche possono essere sfruttati in questo contesto. Poiché la gestione del frutteto è una delle applicazioni più impegnative, a causa della sua struttura arborea e della necessaria interazione con l'ambiente, è stata oggetto di ricerca per fornire una soluzione personalizzata che sviluppi un nuovo concetto di veicolo agricolo. Il risultato si è concretizzato in un veicolo cingolato leggero, capace di effettuare una navigazione autonoma sia nello scenario di pieno campo che all'interno dei frutteti (navigazione interfilare). La progettazione meccanica, insieme all'implementazione del software, sono stati dettagliati per evidenziarne i punti di forza, accanto ad alcuni ulteriori miglioramenti previsti per incrementarne le prestazioni complessive. I test di stabilità statica hanno dimostrato che il veicolo può resistere a ripidi pendii. Sono stati inoltre studiati miglioramenti per affinare la stima dello slittamento che si verifica durante le manovre di svolta, tipico dei veicoli cingolati. L'architettura software è stata implementata utilizzando il framework Robot Operating System (ROS), in modo da sfruttare i pacchetti disponibili relativi a componenti base, come le interfacce dei sensori, e consentendo al contempo un'implementazione personalizzata degli algoritmi di navigazione sviluppati. I test in condizioni reali all'interno dei frutteti sperimentali dell'università hanno dimostrato la robustezza e la stabilità della soluzione con oltre 800 ore di lavoro sul campo. Il veicolo ha permesso di attivare e svolgere un'ampia gamma di attività agricole in maniera autonoma, come l'irrorazione, la falciatura e la raccolta di dati sul campo. Questi ultimi possono essere sfruttati per stimare automaticamente le proprietà più rilevanti del frutteto, come il conteggio e la calibratura dei frutti, la stima delle proprietà della chioma e la raccolta autonoma dei frutti con stime post-raccolta
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