Testing Inflation with Large Scale Structure: Connecting Hopes with Reality

The statistics of primordial curvature fluctuations are our window into the period of inflation, where these fluctuations were generated. To date, the cosmic microwave background has been the dominant source of information about these perturbations. Large scale structure is however from where drastic improvements should originate. In this paper, we explain the theoretical motivations for pursuing such measurements and the challenges that lie ahead. In particular, we discuss and identify theoretical targets regarding the measurement of primordial non-Gaussianity. We argue that when quantified in terms of the local (equilateral) template amplitude $f_{\rm NL}^{\rm loc}$ ($f_{\rm NL}^{\rm eq}$), natural target levels of sensitivity are $\Delta f_{\rm NL}^{\rm loc, eq.} \simeq 1$. We highlight that such levels are within reach of future surveys by measuring 2-, 3- and 4-point statistics of the galaxy spatial distribution. This paper summarizes a workshop held at CITA (University of Toronto) on October 23-24, 2014.Comment: 27 pages + reference

Serum proteomics of active tuberculosis patients and contacts reveals unique processes activated during Mycobacterium tuberculosis infection.

Tuberculosis (TB) is the most lethal infection among infectious diseases. The specific aim of this study was to establish panels of serum protein biomarkers representative of active TB patients and their household contacts who were either infected (LTBI) or uninfected (EMI-TB Discovery Cohort, Pontevedra Region, Spain). A TMT (Tamdem mass tags) 10plex-based quantitative proteomics study was performed in quintuplicate containing a total of 15 individual serum samples per group. Peptides were analyzed in an LC-Orbitrap Elite platform, and raw data were processed using Proteome Discoverer 2.1. A total of 418 proteins were quantified. The specific protein signature of active TB patients was characterized by an accumulation of proteins related to complement activation, inflammation and modulation of immune response and also by a decrease of a small subset of proteins, including apolipoprotein A and serotransferrin, indicating the importance of lipid transport and iron assimilation in the progression of the disease. This signature was verified by the targeted measurement of selected candidates in a second cohort (EMI-TB Verification Cohort, Maputo Region, Mozambique) by ELISA and nephelometry techniques. These findings will aid our understanding of the complex metabolic processes associated with TB progression from LTBI to active disease

Correlations between 21 cm Radiation and the CMB from Active Sources

Neutral hydrogen is ubiquitous, absorbing and emitting 21 cm radiation throughout much of the Universe's history. Active sources of perturbations, such as cosmic strings, would generate simultaneous perturbations in the distribution of neutral hydrogen and in the Cosmic Microwave Background (CMB) radiation from recombination. Moving strings would create wakes leading to 21 cm brightness fluctuations, while also perturbing CMB light via the Gott-Kaiser-Stebbins effect. This would lead to spatial correlations between the 21 cm and CMB anisotropies. Passive sources, like inflationary perturbations, predict no cross correlations prior to the onset of reionization. Thus, observation of any cross correlation between CMB and 21 cm radiation from dark ages would constitute evidence for new physics. We calculate the cosmic string induced correlations between CMB and 21 cm and evaluate their observability.Comment: 8 pages, 5 figure

Towards a holographic realization of the quarkyonic phase

Large-N_c QCD matter at intermediate baryon density and low temperatures has been conjectured to be in the so-called quarkyonic phase, i.e., to have a quark Fermi surface and on top of it a confined spectrum of excitations. It has been suggested that the presence of the quark Fermi surface leads to a homogeneous phase with restored chiral symmetry, which is unstable towards creating condensates breaking both the chiral and translational symmetry. Motivated by these exotic features, we investigate properties of cold baryonic matter in the single flavor Sakai-Sugimoto model searching for a holographic realization of the quarkyonic phase. We use a simplified mean-field description and focus on the regime of parametrically large baryon densities, of the order of the square of the 't Hooft coupling, as they turn out to lead to new physical effects similar to the ones occurring in the quarkyonic phase. One effect, the appearance of a particular marginally stable mode breaking translational invariance and linked with the presence of the Chern-Simons term in the flavor brane Lagrangian, is known to occur in the deconfined phase of the Sakai-Sugimoto model, but turns out to be absent here. The other, completely new phenomenon that we, preliminarily, study using strong simplifying assumptions are density-enhanced interactions of the flavor brane gauge field with holographically represented baryons. These seem to significantly affect the spectrum of vector and axial mesons and might lead to approximate chiral symmetry restoration in the lowest part of the spectrum, where the mesons start to qualitatively behave like collective excitations of the dense baryonic medium. We discuss the relevance of these effects for holographic searches of the quarkyonic phase and conclude with a discussion of various subtleties involved in constructing a mean-field holographic description of a dense baryonic medium.Comment: 31 pages, 16 figures; v2: inset plot in Fig. 10 removed, coloring in Fig. 13 fixed, typos fixed, matches published versio