1,276 research outputs found
Machine Learning for Multiclass Classification and Prediction of Alzheimer\u27s Disease
Alzheimer\u27s disease (AD) is an irreversible neurodegenerative disorder and a common form of dementia. This research aims to develop machine learning algorithms that diagnose and predict the progression of AD from multimodal heterogonous biomarkers with a focus placed on the early diagnosis. To meet this goal, several machine learning-based methods with their unique characteristics for feature extraction and automated classification, prediction, and visualization have been developed to discern subtle progression trends and predict the trajectory of disease progression.
The methodology envisioned aims to enhance both the multiclass classification accuracy and prediction outcomes by effectively modeling the interplay between the multimodal biomarkers, handle the missing data challenge, and adequately extract all the relevant features that will be fed into the machine learning framework, all in order to understand the subtle changes that happen in the different stages of the disease. This research will also investigate the notion of multitasking to discover how the two processes of multiclass classification and prediction relate to one another in terms of the features they share and whether they could learn from one another for optimizing multiclass classification and prediction accuracy.
This research work also delves into predicting cognitive scores of specific tests over time, using multimodal longitudinal data. The intent is to augment our prospects for analyzing the interplay between the different multimodal features used in the input space to the predicted cognitive scores. Moreover, the power of modality fusion, kernelization, and tensorization have also been investigated to efficiently extract important features hidden in the lower-dimensional feature space without being distracted by those deemed as irrelevant.
With the adage that a picture is worth a thousand words, this dissertation introduces a unique color-coded visualization system with a fully integrated machine learning model for the enhanced diagnosis and prognosis of Alzheimer\u27s disease. The incentive here is to show that through visualization, the challenges imposed by both the variability and interrelatedness of the multimodal features could be overcome. Ultimately, this form of visualization via machine learning informs on the challenges faced with multiclass classification and adds insight into the decision-making process for a diagnosis and prognosis
Alzheimers Disease Diagnosis using Machine Learning: A Review
Alzheimers Disease AD is an acute neuro disease that degenerates the brain
cells and thus leads to memory loss progressively. It is a fatal brain disease
that mostly affects the elderly. It steers the decline of cognitive and
biological functions of the brain and shrinks the brain successively, which in
turn is known as Atrophy. For an accurate diagnosis of Alzheimers disease,
cutting edge methods like machine learning are essential. Recently, machine
learning has gained a lot of attention and popularity in the medical industry.
As the illness progresses, those with Alzheimers have a far more difficult time
doing even the most basic tasks, and in the worst case, their brain completely
stops functioning. A persons likelihood of having early-stage Alzheimers
disease may be determined using the ML method. In this analysis, papers on
Alzheimers disease diagnosis based on deep learning techniques and
reinforcement learning between 2008 and 2023 found in google scholar were
studied. Sixty relevant papers obtained after the search was considered for
this study. These papers were analysed based on the biomarkers of AD and the
machine-learning techniques used. The analysis shows that deep learning methods
have an immense ability to extract features and classify AD with good accuracy.
The DRL methods have not been used much in the field of image processing. The
comparison results of deep learning and reinforcement learning illustrate that
the scope of Deep Reinforcement Learning DRL in dementia detection needs to be
explored.Comment: 10 pages and 3 figure
Computational Language Assessment in patients with speech, language, and communication impairments
Speech, language, and communication symptoms enable the early detection,
diagnosis, treatment planning, and monitoring of neurocognitive disease
progression. Nevertheless, traditional manual neurologic assessment, the speech
and language evaluation standard, is time-consuming and resource-intensive for
clinicians. We argue that Computational Language Assessment (C.L.A.) is an
improvement over conventional manual neurological assessment. Using machine
learning, natural language processing, and signal processing, C.L.A. provides a
neuro-cognitive evaluation of speech, language, and communication in elderly
and high-risk individuals for dementia. ii. facilitates the diagnosis,
prognosis, and therapy efficacy in at-risk and language-impaired populations;
and iii. allows easier extensibility to assess patients from a wide range of
languages. Also, C.L.A. employs Artificial Intelligence models to inform theory
on the relationship between language symptoms and their neural bases. It
significantly advances our ability to optimize the prevention and treatment of
elderly individuals with communication disorders, allowing them to age
gracefully with social engagement.Comment: 36 pages, 2 figures, to be submite
AD-BERT: Using Pre-trained contextualized embeddings to Predict the Progression from Mild Cognitive Impairment to Alzheimer's Disease
Objective: We develop a deep learning framework based on the pre-trained
Bidirectional Encoder Representations from Transformers (BERT) model using
unstructured clinical notes from electronic health records (EHRs) to predict
the risk of disease progression from Mild Cognitive Impairment (MCI) to
Alzheimer's Disease (AD). Materials and Methods: We identified 3657 patients
diagnosed with MCI together with their progress notes from Northwestern
Medicine Enterprise Data Warehouse (NMEDW) between 2000-2020. The progress
notes no later than the first MCI diagnosis were used for the prediction. We
first preprocessed the notes by deidentification, cleaning and splitting, and
then pretrained a BERT model for AD (AD-BERT) based on the publicly available
Bio+Clinical BERT on the preprocessed notes. The embeddings of all the sections
of a patient's notes processed by AD-BERT were combined by MaxPooling to
compute the probability of MCI-to-AD progression. For replication, we conducted
a similar set of experiments on 2563 MCI patients identified at Weill Cornell
Medicine (WCM) during the same timeframe. Results: Compared with the 7 baseline
models, the AD-BERT model achieved the best performance on both datasets, with
Area Under receiver operating characteristic Curve (AUC) of 0.8170 and F1 score
of 0.4178 on NMEDW dataset and AUC of 0.8830 and F1 score of 0.6836 on WCM
dataset. Conclusion: We developed a deep learning framework using BERT models
which provide an effective solution for prediction of MCI-to-AD progression
using clinical note analysis
Automated detection of Alzheimer disease using MRI images and deep neural networks- A review
Early detection of Alzheimer disease is crucial for deploying interventions
and slowing the disease progression. A lot of machine learning and deep
learning algorithms have been explored in the past decade with the aim of
building an automated detection for Alzheimer. Advancements in data
augmentation techniques and advanced deep learning architectures have opened up
new frontiers in this field, and research is moving at a rapid speed. Hence,
the purpose of this survey is to provide an overview of recent research on deep
learning models for Alzheimer disease diagnosis. In addition to categorizing
the numerous data sources, neural network architectures, and commonly used
assessment measures, we also classify implementation and reproducibility. Our
objective is to assist interested researchers in keeping up with the newest
developments and in reproducing earlier investigations as benchmarks. In
addition, we also indicate future research directions for this topic.Comment: 22 Pages, 5 Figures, 7 Table
Alzheimers Disease Diagnosis by Deep Learning Using MRI-Based Approaches
The most frequent kind of dementia of the nervous system, Alzheimer's
disease, weakens several brain processes (such as memory) and eventually
results in death. The clinical study uses magnetic resonance imaging to
diagnose AD. Deep learning algorithms are capable of pattern recognition and
feature extraction from the inputted raw data. As early diagnosis and stage
detection are the most crucial elements in enhancing patient care and treatment
outcomes, deep learning algorithms for MRI images have recently allowed for
diagnosing a medical condition at the beginning stage and identifying
particular symptoms of Alzheimer's disease. As a result, we aimed to analyze
five specific studies focused on AD diagnosis using MRI-based deep learning
algorithms between 2021 and 2023 in this study. To completely illustrate the
differences between these techniques and comprehend how deep learning
algorithms function, we attempted to explore selected approaches in depth
Biomedical Data Classification with Improvised Deep Learning Architectures
With the rise of very powerful hardware and evolution of deep learning architectures, healthcare data analysis and its applications have been drastically transformed. These transformations mainly aim to aid a healthcare personnel with diagnosis and prognosis of a disease or abnormality at any given point of healthcare routine workflow. For instance, many of the cancer metastases detection depends on pathological tissue procedures and pathologist reviews. The reports of severity classification vary amongst different pathologist, which then leads to different treatment options for a patient. This labor-intensive work can lead to errors or mistreatments resulting in high cost of healthcare. With the help of machine learning and deep learning modules, some of these traditional diagnosis techniques can be improved and aid a doctor in decision making with an unbiased view. Some of such modules can help reduce the cost, shortage of an expertise, and time in identifying the disease.
However, there are many other datapoints that are available with medical images, such as omics data, biomarker calculations, patient demographics and history. All these datapoints can enhance disease classification or prediction of progression with the help of machine learning/deep learning modules. However, it is very difficult to find a comprehensive dataset with all different modalities and features in healthcare setting due to privacy regulations. Hence in this thesis, we explore both medical imaging data with clinical datapoints as well as genomics datasets separately for classification tasks using combinational deep learning architectures. We use deep neural networks with 3D volumetric structural magnetic resonance images of Alzheimer Disease dataset for classification of disease. A separate study is implemented to understand classification based on clinical datapoints achieved by machine learning algorithms. For bioinformatics applications, sequence classification task is a crucial step for many metagenomics applications, however, requires a lot of preprocessing that requires sequence assembly or sequence alignment before making use of raw whole genome sequencing data, hence time consuming especially in bacterial taxonomy classification. There are only a few approaches for sequence classification tasks that mainly involve some convolutions and deep neural network. A novel method is developed using an intrinsic nature of recurrent neural networks for 16s rRNA sequence classification which can be adapted to utilize read sequences directly. For this classification task, the accuracy is improved using optimization techniques with a hybrid neural network
Advancements in Medical Imaging and Diagnostics with Deep Learning Technologies
Medical imaging has long been a cornerstone in diagnostic medicine, providing clinicians with a non-invasive method to visualize internal structures and processes. However, traditional imaging techniques have faced challenges in resolution, safety concerns related to radiation exposure, and the need for invasive procedures for clearer visualization. With the advent of deep learning technologies, significant advancements have been made in the field of medical imaging, addressing many of these challenges and introducing new capabilities. This research seeks into the integration of deep learning in enhancing image resolution, leading to clearer and more detailed visualizations. Furthermore, the ability to reconstruct three-dimensional images from traditional two-dimensional scans offers a more comprehensive view of the area under examination. Automated analysis powered by deep learning algorithms not only speeds up the diagnostic process but also detects anomalies that might be overlooked by the human eye. Predictive analysis, based on these enhanced images, can forecast the likelihood of diseases, and real-time analysis during surgeries ensures immediate feedback, enhancing the precision of medical procedures. Safety in medical imaging has also seen improvements. Techniques powered by deep learning require reduced radiation, minimizing risks to patients. Additionally, the enhanced clarity and detail in images reduce the need for invasive procedures, further ensuring patient safety. The integration of imaging data with Electronic Health Records (EHR) has paved the way for personalized care recommendations, tailoring treatments based on individual patient history and current diagnostics. Lastly, the role of deep learning extends to medical education, where it aids in creating realistic simulations and models, equipping medical professionals with better training tools
Digital twin brain: a bridge between biological intelligence and artificial intelligence
In recent years, advances in neuroscience and artificial intelligence have
paved the way for unprecedented opportunities for understanding the complexity
of the brain and its emulation by computational systems. Cutting-edge
advancements in neuroscience research have revealed the intricate relationship
between brain structure and function, while the success of artificial neural
networks highlights the importance of network architecture. Now is the time to
bring them together to better unravel how intelligence emerges from the brain's
multiscale repositories. In this review, we propose the Digital Twin Brain
(DTB) as a transformative platform that bridges the gap between biological and
artificial intelligence. It consists of three core elements: the brain
structure that is fundamental to the twinning process, bottom-layer models to
generate brain functions, and its wide spectrum of applications. Crucially,
brain atlases provide a vital constraint, preserving the brain's network
organization within the DTB. Furthermore, we highlight open questions that
invite joint efforts from interdisciplinary fields and emphasize the
far-reaching implications of the DTB. The DTB can offer unprecedented insights
into the emergence of intelligence and neurological disorders, which holds
tremendous promise for advancing our understanding of both biological and
artificial intelligence, and ultimately propelling the development of
artificial general intelligence and facilitating precision mental healthcare
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