Visualizing Convolutional Networks for MRI-based Diagnosis of Alzheimer's Disease

Visualizing and interpreting convolutional neural networks (CNNs) is an important task to increase trust in automatic medical decision making systems. In this study, we train a 3D CNN to detect Alzheimer's disease based on structural MRI scans of the brain. Then, we apply four different gradient-based and occlusion-based visualization methods that explain the network's classification decisions by highlighting relevant areas in the input image. We compare the methods qualitatively and quantitatively. We find that all four methods focus on brain regions known to be involved in Alzheimer's disease, such as inferior and middle temporal gyrus. While the occlusion-based methods focus more on specific regions, the gradient-based methods pick up distributed relevance patterns. Additionally, we find that the distribution of relevance varies across patients, with some having a stronger focus on the temporal lobe, whereas for others more cortical areas are relevant. In summary, we show that applying different visualization methods is important to understand the decisions of a CNN, a step that is crucial to increase clinical impact and trust in computer-based decision support systems.Comment: MLCN 201

Flowing ConvNets for Human Pose Estimation in Videos

The objective of this work is human pose estimation in videos, where multiple frames are available. We investigate a ConvNet architecture that is able to benefit from temporal context by combining information across the multiple frames using optical flow. To this end we propose a network architecture with the following novelties: (i) a deeper network than previously investigated for regressing heatmaps; (ii) spatial fusion layers that learn an implicit spatial model; (iii) optical flow is used to align heatmap predictions from neighbouring frames; and (iv) a final parametric pooling layer which learns to combine the aligned heatmaps into a pooled confidence map. We show that this architecture outperforms a number of others, including one that uses optical flow solely at the input layers, one that regresses joint coordinates directly, and one that predicts heatmaps without spatial fusion. The new architecture outperforms the state of the art by a large margin on three video pose estimation datasets, including the very challenging Poses in the Wild dataset, and outperforms other deep methods that don't use a graphical model on the single-image FLIC benchmark (and also Chen & Yuille and Tompson et al. in the high precision region).Comment: ICCV'1