History-based action selection bias in posterior parietal cortex.

Making decisions based on choice-outcome history is a crucial, adaptive ability in life. However, the neural circuit mechanisms underlying history-dependent decision-making are poorly understood. In particular, history-related signals have been found in many brain areas during various decision-making tasks, but the causal involvement of these signals in guiding behavior is unclear. Here we addressed this issue utilizing behavioral modeling, two-photon calcium imaging, and optogenetic inactivation in mice. We report that a subset of neurons in the posterior parietal cortex (PPC) closely reflect the choice-outcome history and history-dependent decision biases, and PPC inactivation diminishes the history dependency of choice. Specifically, many PPC neurons show history- and bias-tuning during the inter-trial intervals (ITI), and history dependency of choice is affected by PPC inactivation during ITI and not during trial. These results indicate that PPC is a critical region mediating the subjective use of history in biasing action selection

Data-Space Inversion with Ensemble Smoother

Reservoir engineers use large-scale numerical models to predict the production performance in oil and gas fields. However, these models are constructed based on scarce and often inaccurate data, making their predictions highly uncertain. On the other hand, measurements of pressure and flow rates are constantly collected during the operation of the field. The assimilation of these data into the reservoir models (history matching) helps to mitigate uncertainty and improve their predictive capacity. History matching is a nonlinear inverse problem, which is typically handled using optimization and Monte Carlo methods. In practice, however, generating a set of properly history-matched models that preserve the geological realism is very challenging, especially in cases with complicated prior description, such as models with fractures and complex facies distributions. Recently, a new data-space inversion (DSI) approach was introduced in the literature as an alternative to the model-space inversion used in history matching. The essential idea is to update directly the predictions from a prior ensemble of models to account for the observed production history without updating the corresponding models. The present paper introduces a DSI implementation based on the use of an iterative ensemble smoother and demonstrates with examples that the new implementation is computationally faster and more robust than the earlier method based on principal component analysis. The new DSI is also applied to estimate the production forecast in a real field with long production history and a large number of wells. For this field problem, the new DSI obtained forecasts comparable with a more traditional ensemble-based history matching.Comment: 33 pages, 14 figure

Museum Learning via Social Media: (How) Can Interactions on Twitter Enhance the Museum Learning Experience?

Museums are rich sources of artifacts, people and potential dialogic interactions. Recent developments in web technologies pose big challenges to museums to integrate such technologies in their learning provision. The study presented here is concerned with the potential of how school visits to museums can be enhanced by the use of social media. The Museum of London (MoL) is selected as the site of the study and the participants were a Year 9 History class (13-14 years old) in a secondary school in Milton Keynes. It draws on Falk and Dierking’s (2000) Contextual Model of Learning and considers evidence of meaning making from students’ tweets and activity on-site. Observational data during the visit, the visit’s Twitter stream and post-visit interview data with the participants is presented and analysed. It is argued that use of Twitter, a microblogging platform (http://twitter.com), enhances the social interaction around museum artifacts and thus, the process of shared construction of meaning making, which can enrich the museum experience

The VizieR database of Astronomical Catalogues

VizieR is a database grouping in an homogeneous way thousands of astronomical catalogues gathered since decades by the Centre de Donnees de Strasbourg (CDS) and participating institutes. The history and current status of this large collection is briefly presented, and the way these catalogues are being standardized to fit in the VizieR system is described. The architecture of the database is then presented, with emphasis on the management of links and of accesses to very large catalogues. Several query interfaces are currently available, making use of the ASU protocol, for browsing purposes or for use by other data processing systems such as visualisation tools.Comment: 10 pages, 2 Postscript figures; to be published in A&A

The polaroid image as photo-object

This article is part of a larger project on the cultural history of Polaroid photography and draws on research done at the Polaroid Corporate archive at Harvard and at the Polaroid company itself. It identifies two cultural practices engendered by Polaroid photography, which, at the point of its extinction, has briefly flared into visibility again. It argues that these practices are mistaken as novel but are in fact rediscoveries of practices that stretch back as many as five decades. The first section identifies Polaroid image-making as a photographic equivalent of what Tom Gunning calls the ‘cinema of attractions’. That is, the emphasis in its use is on the display of photographic technologies rather than the resultant image. Equally, the common practice, in both fine art and vernacular circles, of making composite pictures with Polaroid prints, draws attention from image content and redirects it to the photo as object

“A Little History Here, a Little Hollywood There”: (Counter-) Identifying with the Spanish Fantasy in Carlos Morton’s Rancho Hollywood and Theresa Chavez’s L.A. Real

Often considered the final conquest and ultimate summation of Manifest Destiny, California holds a unique place in the American imaginary. While the popular mythology of the Spanish fantasy has served to obscure the use of violence and racialized oppression throughout the colonization of the American Southwest, traces of such struggle remain in memories of the colonized as they continue to occupy this contested space. This paper examines Carlos Morton’s ensemble-based political satire, Rancho Hollywood, and Theresa Chavez’s one-woman show, L.A. Real, to navigate the dynamic experience of contemporary Southern Californian racialized identity. These two pieces diverge stylistically but share an inclusive, nuanced approach to making sense of history, exploring the material and epistemological impact of historical representation on Chicana/o identity over time. Rancho Hollywood and L.A. Real counter-identify with the Spanish-fantasy heritage by rejecting stereotyping, questioning sanitized versions of Californian history, and voicing personal narratives that resist dominant regional myths and their associated racial ascriptions. Each play stages alternative versions of history that include personal experience and cultural memory; this transformative, productive approach to identity formation articulates agency over the memory of California

Therapeutic decision making in autoimmune and inflammatory disorders of the central nervous system in children.

ABSTRACT Autoimmune and inflammatory disorders of the central nervous system can result in significant morbidity and mortality. Through the recognition of syndromes using diagnostic biomarkers, the clinician is now able to use immune suppressive therapies to improve outcomes. However, the therapeutic decision-making process is complex. The clinician has to balance the risk of disease, with the risk of treatment side effects. To achieve this balance, it is important to understand the natural history of disease, the risk of residual disability, the risk of relapse, and risk of a fatal outcome. It is also important to have some understanding of the pathological processes, as some of the entities have more reversible processes, whereas others have destructive processes. This review will assess the dynamic nature of this decision-making process, and compare some of the more severe diseases such as neuromyelitis optica, anti-N-methyl-D-aspartate receptor encephalitis and opsoclonus myoclonus ataxia syndrome, with disorders with more favourable outcomes such as Sydenham chorea and post-infectious cerebellar ataxia

"Of Mice and Measures": A Project to Improve How We Advance Duchenne Muscular Dystrophy Therapies to the Clinic

A new line of dystrophic mdx mice on the DBA/2J (D2) background has emerged as a candidate to study the efficacy of therapeutic approaches for Duchenne muscular dystrophy (DMD). These mice harbor genetic polymorphisms that appear to increase the severity of the dystropathology, with disease modifiers that also occur in DMD patients, making them attractive for efficacy studies and drug development. This workshop aimed at collecting and consolidating available data on the pathological features and the natural history of these new D2/mdx mice, for comparison with classic mdx mice and controls, and to identify gaps in information and their potential value. The overall aim is to establish guidance on how to best use the D2/mdx mouse model in preclinical studies

Taming Augustine’s Monstrosity: Aquinas’s Notion of Use in the Struggle for Moral Growth

In Book VI of his Confessions, Saint Augustine offers a detailed description of one of the most famous cases of weakness of will in the history of philosophy. Augustine characterizes his experience as a monstrous situation in which he both wills and does not will moral growth, but he is at odds to explain this phenomenon. In this paper, I argue that Aquinas’s action theory offers important resources for explaining Augustine’s monstrosity. On Aquinas’s schema, human acts are composed of various operations of intellect and will, and thus are subject to disintegration. In order to capture the gap in human action between making choices to pursue particular goals and translating those choices into behavior, Aquinas distinguishes between two operations of will that he calls choice and use. I apply hisdistinction between choice and use to Augustine’s case, arguing that Augustine’s moral weakness is a result of will’s failure to use its choices. The central thesis of this paper is that Augustine’s monstrosity is a bona fide case of weakness of will that is best explained as a failure in use at the level of will